The Role of Regucalcin in Cell Homeostasis and Disorder

Masayoshi Yamaguchi, Ph.D.
Department of Hematology and Medical Oncology, Emory University, School of Medicine, Atlanta, Georgia, USA

Series: Recent Advances in Hematology Research
BISAC: MED038000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Cyclic AMP was a major molecule of interest, which played an important role as second messenger, contributing to signal transduction in the regulation of cellular function by peptide hormones. Afterwards, calmodulin and protein kinase C were discovered as modulator proteins of intracellular calcium signaling in hormonal action. After that, manifold proteins and their related molecules were demonstrated to participate in novel signaling pathways related to various cytokines in different types of cells. The author of this book discovered a novel protein known as “regucalcin”, which suppresses manifold signaling pathways related to transcription activity. After subsequent studies, regucalcin has been established to play a pivotal role in maintaining cell homeostasis and protecting it from disorders in various types of cells and tissues. This book will provide information regarding regucalcin that plays a pivotal role in cell homeostasis and disorder.
This book is composed of eighteen chapters. These chapters include the following content: the discovery of regucalcin (Chapter One); chemical property and structure of regucalcin (Chapter Two); the regucalcin gene and its translational regulation (Chapter Three); the role of regucalcin in intracellular calcium homeostasis (Chapter Four); the role of regucalcin in cell nuclear function (Chapter Five); the role of regucalcin in protein synthesis and proteolysis (Chapter Six); the suppressive role of regucalcin in cell proliferation (Chapter Seven); how regucalcin protects apoptotic cell death (Chapter Eight); the protective role of regucalcin in oxidative stress (Chapter Nine); the involvement of regucalcin in liver metabolic disorder (Chapter Ten); the role of regucalcin in kidney cell homeostasis: involvement in renal failure (Chapter Eleven); the role of regucalcin in heart calcium signaling: insight into cardiac disorder (Chapter Twelve); the role of regucalcin in brain calcium homeostasis: disorder with aging (Chapter Thirteen); the role of regucalcin in bone homeostasis and osteoporosis (Chapter Fourteen); the role of regucalcin in lipid metabolism and diabetes (Chapter Fifteen); the role of regucalcin as a suppressor protein in carcinogenesis (Chapter Sixteen); the clinical aspects of regucalcin as a biomarker for disease (Chapter Seventeen); and conclusive remarks (Chapter Eighteen). This book will provide information regarding regucalcin and its pivotal role in cell homeostasis and disorder. (Imprint: Nova Biomedical)

Preface

Chapter 1. Discover of Regucalcin

Chapter 2. Chemical Property and Structure of Regucalcin

Chapter 3. Regucalcin Gene and Its Translational Regulation

Chapter 4. Role of Regucalcin in Cell Calcium Homeostasis

Chapter 5. Role of Regucalcin in Cell Nuclear Regulation

Chapter 6. Role of Regucalcin in Protein Synthesis and Proteolysis

Chapter 7. Suppressive Role of Regucalcin in Cell Proliferation

Chapter 8. Regucalcin Protects Apoptotic Cell Death

Chapter 9. Protective Role of Regucalcin in Oxidative Stress

Chapter 10. Involvement of Regucalcin in Liver Metabolic Disorder

Chapter 11. Role of Regucalcin in Kidney Cell Homeostasis Involvement in Renal Failure

Chapter 12. Role of Regucalcin in Heart Calcium Signaling: Insight into Cardiac Disorder

Chapter 13. Role of Regucalcin in Brain Calcium Homeostasis: Disorder with Aging

Chapter 14. Role of Regucalcin in Bone Homeostasis and Osteoporosis

Chapter 15. Role of Regucalcin in Lipid Metabolism and Diabetes

Chapter 16. Role of Regucalcin as a Suppressor in Carcinogenesis

Chapter 17. Clinical Aspects of Regucalcin as a Biomarker for Diseases

Chapter 18. Conclusion

References

Author's Biography

Index

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