The Role of Reactive Oxygen Species in Health and Disease

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Kuladip Jana, PhD – Principal Scientist, Division of Molecular Medicine, Scientist In-Charge, Centre of Translational Animal Research (CTAR), Bose Institute, India

Series: Public Health in the 21st Century; Life Sciences Research and Development
BISAC: SCI008000; SCI049000; MED071000
DOI: https://doi.org/10.52305/TRSI2511

Reactive oxygen species (ROS) play an essential role in different biological functions, including physiological regulatory mechanisms to damaging alterations involved in the pathogenesis of an increasing number of human diseases. ROS are metabolic products from numerous cells, but two vital cellular organelles are intimately involved in their production and metabolism, i.e. the endoplasmic reticulum and the mitochondria. Excess cellular levels of ROS may cause damage to proteins, nucleic acids, lipids, membranes, and organelles, which may lead to the activation of cell death processes such as apoptosis. Apoptosis is a highly regulated process that is essential for the development and survival of multicellular organisms. These organisms often need to discard superfluous or potentially harmful cells, have accumulated mutations, or become infected by pathogens. Apoptosis features a characteristic set of morphological and biochemical features whereby cells undergo a cascade of self-destruction. Thus, proper regulation of apoptosis is essential for maintaining normal cellular homeostasis. Mitochondrial ROS (mtROS) play a central role in cell signaling and regulating the main pathways of apoptosis, mediated by mitochondria, death receptors, and the endoplasmic reticulum (ER) stress. This book focuses on the current understanding of the role of ROS in each of these three main pathways of apoptosis related to different human diseases, with particular emphasis on Metabolic, Inflammatory, Neurodegenerative, and Neoplastic diseases. It’s promise and limitations are also discussed by targeting ROS with different antioxidants in preventing non-communicable diseases. The role of mtROS in the complex interplay and crosstalk between these different signaling pathways of apoptosis related to different human diseases remains to be unraveled further in future research.

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Table of Contents

Preface

Chapter 1. Reactive Oxygen Species Act as Double-Edged Swords in Cancer Progression and Therapy
Satyajit Halder and Kuladip Jana
Division of Molecular Medicine, Bose Institute, Bidhan Nagar, Kolkata, West Bengal, India

Chapter 2. The Interplay Between Endoplasmic Reticulum Stress Mediated ROS Generation and Apoptosis in Human Diseases
Satyajit Halder1, Nikhilesh Joardar2,3, Rajkumar Maiti4, Shanti Prasad Sinha Babu3, Debidas Ghosh5 and Kuladip Jana1
1Division of Molecular Medicine, Bose Institute, Calcutta Improvement Trust Scheme VII M, Salt Lake City, Bidhannagar, Kolkata, India
2Infectious Disease Division, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri, USA
3Parasitology Laboratory, Department of Zoology, Siksha Bhavana, Visva Bharati, Santiniketan, West Bengal, India
4Department of Physiology, Bankura Christian College, Bankura, India
5Department of Bio-Medical Laboratory Science and Management, Vidyasagar University, Midnapur, India

Chapter 3. The Role of Misfolded Proteins on Oxidative Stress Mediated Neurodegeneration
Nikhilesh Joardar1, Satyajit Halder2, Santi Prasad Sinha Babu3 and Kuladip Jana2
1Infectious Disease Division, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri, USA
2Division of Molecular Medicine, Bose Institute, Bidhan Nagar, Kolkata–West Bengal, India
3Parasitology Laboratory, Department of Zoology, Siksha Bhavana, Visva Bharati, Santiniketan, West Bengal, India

Chapter 4. The Mechanism of Mitochondrial Reactive Oxygen Species (mtROS) Generation and Its Role in the Apoptosis, Pathogenesis of Inflammatory and Neurodegenerative Disorders
Chirantan Majumder, Anirban Manna, Satyajit Halder and Kuladip Jana
Division of Molecular Medicine, Kolkata, India
Unified Academic Campus, Division of Molecular Medicine, Salt Lake City, Bidhannagar, Kolkata, India

Chapter 5. Reactive Oxygen Species: Its Role in the Aging of the Brain and Neurodegenerative Diseases
Anirban Manna, Chirantan Majumder, Satyajit Halder and Kuladip Jana
Division of Molecular Medicine, Centenary Campus, Bose Institute P-1/12 C.I.T. Scheme VII-M, Kolkata and Unified Academic Campus, Division of Molecular Medicine, Salt Lake City, Bidhannagar, Kolkata, India

Chapter 6. Targeting Reactive Oxygen Species (ROS) in the Prevention of Non-Communicable Diseases: The Promise and Limitations of Antioxidant Therapy
Satyajit Halder1, Chirantan Majumder1, Anirban Manna1, Sarita Sarkar2 Ankita Bhattachrya3 and Kuladip Jana1
1Division of Molecular Medicine, Bose Institute, Bidhan Nagar, Kolkata, West Bengal, India
2Department of Biotechnology, The Neotia University, Sarisha, West Bengal, India
3Department of Biochemistry, K. P. C. Medical College and Hospital, Kolkata, India

Chapter 7. Parkinson’s Disease and Oxidative Stress
Nabanita Ghosh1, Krishnendu Sinha2 and Parames C. Sil3
1Maulana Azad College, Kolkata, India
2Jhargram Raj College, Jhargram, India
3Division of Molecular Medicine, Bose Institute, Kolkata, India

Chapter 8. The Role of ROS in Cancer Progression and Therapy
Subhajit Ghosh, Shrestha Dutta and Arghya Adhikary
Department of Life Science and Bio-Technology, Jadavpur University, Poddar Nagar, Jadavpur, Kolkata, West Bengal, India

Chapter 9. Oxidative Stress: A Source of Cellular Plasticity and Tumor Heterogeneity
Leena Arora, Moyna Kalia, Kumari Bhavya and Durba Pal
Department of Biomedical Engineering, Indian Institute of Technology Ropar, Punjab, India

Chapter 10. The Role of Bioactive Compounds and Associated Nanoparticles in the Regulation of ROS: An Innovative Strategy in Cancer Therapy
Satish Kumar Vemuri1, Chepuri Kalyani2, C. D. S. L. N. Tulasi2, D. Manikantha2, G. P. V. Subbaiah1 and A. V. Gurava Reddy1
1SMART, Sunshine Hospitals, Secunderabad, Hyderabad, Telangana State, India
2Jawaharlal Nehru Technological University Hyderabad, Telangana State, India

Chapter 11. Reactive Oxygen Species and Cancer: A Split Self Affair
Sangramjit Mondal, Aiindrila Dhara, Debkumar Pal and Nirmalya Sen
Molecular Oncology Laboratory, Department of Biological Sciences, Bose Institute, Kolkata, India

Chapter 12. Interconnecting ROS and EMT: A Way Forward in Cancer Therapy
Debarpan Mitra, Depanwita Saha, Subhabrata Guha, Gaurav Das and Nabendu Murmu
1Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India

Chapter 13. The Dynamic Role of Reactive Oxygen Species in Relation to Ovarian Cancer
Aparajita Pal, Sunita Jhulki and Sukanya Kundu
Diamond Harbour Women’s University, Sarisha, West Bengal, India

Chapter 14. Therapeutic Strategies Targeting Oxidative Stress in Diabetes
Abhishek Sehrawat1, Jayapriya Mishra1, Satinder Kaur1 Inderpal Singh Sidhu2, Bhawana Thukral3, Gurjit Kaur Bhatti4, Sarabjit Singh Mastana5, P. Hemachandra Reddy6 and Jasvinder Singh Bhatti1
1Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda India
2Department of Zoology, Sri Guru Gobind Singh College, Sector 26, Chandigarh India
3Department of Nutrition and Dietetics, University Institute of Applied Health Sciences, Chandigarh University, Mohali India
4Department of Medical Lab Technology, University Institute of Applied Health Sciences, Chandigarh University, Mohali India
5School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
6Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, Texa, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

Chapter 15. Reactive Oxygen Species in the Development and Progression of Type 2 Diabetes
Dipanjan Banerjee and Suman Dasgupta
Metabolic Disease Biology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam, India

Chapter 16. Physiological and Immunoregulatory Roles of Reactive Oxygen Species Mediated Signalling Pathways in Lymphatic Filariasis
Pritha Chakraborty1, Nabarun Chandra Das1 and Suprabhat Mukherjee1
1Integrative Biochemistry and Immunology Laboratory, Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India

Chapter 17. The Impact of Oxidative Stress on Male Infertility Induction and Its Management by Nutraceuticals
Debidas Ghosh1, AdrijaTripathy1, Dipanwita Mitra1 and Puja Das2
1Department of Biomedical Laboratory Science and Management
2Centre for Life Sciences, Vidyasagar University, Midnapore, West Bengal, India

Chapter 18. Fluoride and Arsenic Mediated Oxidative Damage Causing Disorders in the Reproductive System
Priyankar Pal, Sagnik Biswas, Rubia Mondal and Prabir Kumar Mukhopadhyay
Department of Life Sciences, Presidency University, Kolkata, India

Chapter 19. Rethinking Endometriosis Pathophysiology: Judging the Oxidative Balance
Dr. Pratip Chakraborty1, Imon Mitra2 and Dr. Ratna Chattopadhyay1
1Department of Assisted Reproduction, Institute of Reproductive Medicine, Kolkata, India
2School of Medical Science and Technology, Indian Institute of Technology Kharagpur, India

Chapter 20. The Role of ROS-Responsive Biomaterials in Bone-Related Diseases
Yu Wu1,2, Wenhui Hu2 and Shiwu Dong2
1Department of Pharmacy, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China
2Department of Biomedical Materials Science, School of Biomedical Engineering, Army Medical University, Chongqing, China

Chapter 21. Stem Cell: Ageing and Senescence Mechanisms
Ankita Das, Chandrayee Ghatak and Ananya Barui
Centre for Healthcare Science and Technology, IIEST Shibpur, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, India

Chapter 22. Superoxide (O2-): A Biological Prodigy for Developing and Curing Disease
Asis Bala1, Motlalepula Gilbert Matsabisa2, Pallab Kanti Haldar3, Subir Biswas4 And Ashis Kumar Mukherjee1
1Division of Life Sciences, Institute of Advanced Study in Science and Technology (IASST), An Autonomous Institute under the Department of Science & Technology (Govt. of India) Vigyan Path, Guwahati, Assam, India
2Department of Pharmacology, Faculty of Health Sciences, School of Clinical Medicines, University of Free State, Bloemfontein, South Africa
3Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
4Division of Physical Sciences, Institute of Advanced Study in Science and Technology (IASST), An Autonomous Institute under the Department of Science & Technology (Govt. of India) Vigyan Path, Guwahati, Assam, India

Index

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