The Role of Oxidative Stress, Mitochondria Failure, and Cellular Hypoperfusion in the Context of Alzheimer Disease: Past, Present and Future

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Gjumrakch Aliev
President “GALLY” International Biomedical Research Institute Inc., San Antonio, TX, USA; Professor of Cardiovascular, Neuropathology, Gerontology, Health Science and Healthcare Administration.University of Atlanta, Atlanta, Georgia, USA

Series: Neurology – Laboratory and Clinical Research Developments, Aging Issues, Health and Financial Alternatives
BISAC: MED056000

Atherosclerosis and stroke are two leading causes of age-associated disability, dementia, and death. The Centers for Disease Control and Prevention (CDC) and the National Center for Health Statistics recently reported that Alzheimer¡¯s Disease has surpassed diabetes as a leading cause of death. Alzheimer is now the sixth-leading cause of death in the United States. This book discusses the roles of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer Disease. (Imprint: Nova Biomedical )

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Table of Contents

Preface

Chapter 1. Are Mitochondrial Failures a Key Component in Alzheimer Disease?

Chapter 2. In Vivo and in Vitro Assessment of the Brain Mitochondrial Bioenergetics in Aging Rats

Chapter 3. The Pathophysiology of Cerebrovascular Lesions in Alzheimer Disease

Chapter 4. Vascular Pathology in the Pathogenesis of Alzheimer Disease

Chapter 5. Oxidative Stress Induced Mitochondrial Failure and Cellular Hypoperfusion as Primary Pathogenic Factors for the Development and Progression of Alzheimer Disease

Chapter 6. The Relationship between the Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease

Chapter 7. The Relationship between Ischemic Stroke, Oxidative Stress Induced Mitochondrial Failure, and Brain Hypoperfusion in the Context of Vascular Disorder with Neurodegenerative Consequences

Chapter 8. Atherosclerotic Lesions and Mitochondria DNA Deletions as a Primary Hallmark of the Brain Microcirculation: Implication in the Pathogenesis of Alzheimer Disease

Chapter 9. The Three-Vessel Occlusion as a Model of Vascular Dementia: Oxidative Stress and Mitochondrial Failure as an Initiator of Brain Hypoperfusion

Chapter 10. Nitric Oxide as an Accelerating and Initiator of Brain Lesions During the Development of Alzheimer Disease

Chapter 11. The Effect of Chronic Brain Hypoperfusion on the of Vascular Nitric Oxide Activities Associates with the Spatial memory and NOS Enzymes Activities

Chapter 12. The Selective Loss of GRK2 Regulation and Consequent Cerebrovascular Complications and Alzheimer Disease

Chapter 13. The Role of Antioxidants in Health and Age-Associated Diseases

Chapter 14. Oxidative Stress Induced Mitochondrial DNA Deletion as a Primary Hallmark for the Drug Development in the Context of Cerebrovascular Diseases

Chapter 15. Preventive and Therapeutic Effects of the Coenzyme Q10 Supplementation in a Rat Model of Cerebral Ischemia-Reperfusion

Chapter 16. Potential Preventive Effects of Coenzyme Q and Creatine Supplementation on Brain Energy Metabolism in Rats Exposed to Chronic Cerebral Hypoperfusion

Chapter 17. Acetyl-L-Carnitine and Lipoic Acid as Treatment Options for the Amelioration of the Neuronal Mitochondria in Aged Rats

Chapter 18. The Protective Effect of R-¨»-Lipoic Acid and Acetyl-L-Carnitine Regiments in ApoE4 Mice as Models for Alzheimer Disease

Chapter 19. Implication of the Flavones from t h e Root of Scutellaria Baicalensis Georgi as New and More Effective Drugs for the Treatment of Neurodegeneration

Chapter 20. Implication of Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegeneration

Chapter 21. The Integrated Treatment Approach of the Cognitive Function in Demented and Clinically Depressed Patients

Index


Reviews

“This incredible book is a compendium of information on the Photovoice method from a global perspective. It is very readable, and clearly documents the effectiveness of Photovoice as a method of research and empowerment in communities. This methodology also has a clear theoretical base of feminist theory, critical theory, and use of photography as a method. The first chapter is a clear explanation of the Photovoice method and has excellent appendices on the methodology of using this community based qualitative research. The following chapters detail the practical use of this method worldwide, in Mexico, and in the United States. It is clear that Photovoice has impacted many communities in the world and is change agent to impact policy makers. Reading this book will benefit practitioners, students, and academicians.” – <strong>Dr. Steven Granich, Lock Haven University, Pennsylvania, USA</strong>

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