The Placenta: Development, Function and Diseases


Richard Nicholson (Editor)
Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, Australia

Series: Pregnancy and Infants: Medical, Psychological and Social Issues, Human Reproductive System – Anatomy, Roles and Disorders
BISAC: MED033000

The placenta plays an essential role in childbirth. It becomes disposable after the baby is born which makes it the only organ in the human body that serves a vital function and then becomes obsolete. It is an extremely complex piece of biological equipment which allows the mother’s and the baby’s blood to come into very close contact, without mixing, to supply nutrients and oxygen to the baby, and move waste products like carbon dioxide back from baby to mother. Thus, the placenta acts as the lung, kidney and digestive system for the baby. The placenta also plays an important role in hormone production.

Human chorionic gonadotropin is produced by the placenta and can be found in the baby’s blood as early as 10 days into pregnancy. The placenta is also responsible for the production of other hormones including estrogen and progesterone, and protects the baby from possible infection, damage by substances found in the environment or used by the mother, such as alcohol, drugs, pollutants and endocrine disruptors. This book presents the reader with a comprehensive, well written and informative collection of chapters written by experts from around the world. It will be a valuable asset for anyone interested in reproduction and pregnancy, and wanting to access excellent reviews as well as the most current discussion of the biology and medicine of the placenta. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents

Preface pp. i-xiii

Chapter 1. An Overview of Development, Function and Diseases of the Placenta
(Usha Verma and Nipun Verma, Department of Obstetrics and Gynecology, Miller School of Medicine, University of Miami, Miami, FL, USA, and others)pp. 1-30

Chapter 2. Emerging Tasks of PAR<sub>1</sub> and PAR<sub>2</sub> in the Placenta Trophoblast Anchoring to the Uterus Decidua
(S. Grisaru-Granovsky, M. Maoz, H. Turm and R. Bar-Shavit, Departments of Obstetrics & Gynecology, Hebrew University Medical Centers, Jerusalem, Israel)pp. 31-42

Chapter 3. Leptin Action and Leptin Receptor Signaling in Human Trophoblast
(Antonio Pérez-Pérez, Flora Sánchez-Jiménez, Julieta L. Maymó, Yésica P. Gambino, José L. Dueñas, Cecilia L. Varone and Víctor Sánchez-Margalet, Department of Medical Biochemistry and Molecular Biology, Virgen Macarena University Hospital, University of Seville, Spain, and others)pp. 43-58

Chapter 4. Immunology of Human Pregnancy: Transfer of Antibodies and Associated Placental Function
(Antoine Malek and Nick A. Bersinger, Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland, and others)pp. 59-80

Chapter 5. Effects of Maternal Nutrition Imbalance During Pregnancy on Outcome in Offspring
(YuXia Chen, Richard C. Nicholson and DongLian Cai, Department of Pathophysiology, Second Military Medical University, Shanghai, China, and others)pp. 81-98

Chapter 6. Role of Placental Hypoxia, Oxidative Stress and Alcohol Exposure in Fetal Development
(Cleofina Bosco, Rodrigo Gutiérrez, Jaime González, Eugenia Diaz and Ramón Rodrigo, Anatomy and Developmental Biology Programme, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, and others)pp. 99-130

Chapter 7. The Role of Nitric Oxide in Placental Function
(Cleofina Bosco, Jaime González, Rodrigo Gutiérrez and Ramón Rodrigo, Anatomy and Developmental Biology Programme, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile, and others)pp. 131-154

Chapter 8. HCG and Hyperglycosylated HCG, Promoters of Villous Placenta and Hemochorial Placentation
(Laurence A. Cole, USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque NM, USA)pp. 155-166

Chapter 9. Exposure to Endocrine Disruptors during Pregnancy and their Potential Health Effects in Newborns
(J. M. Saenz, M. F. Fernandez and N. Olea, Lab Investigaciones Médicas-CIBERESP, University of Granada, San Cecilio University Hospital, Granada, Spain)pp. 167-186

Chapter 10. Placental Transport of Environmental Toxicants
(Line Mathiesen and Lisbeth E. Knudsen, Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Denmark)pp. 187-216

Chapter 11. Placental Toxicology of Organic Pollutants
(Gladis Magnarelli and Natalia Guiñazú, Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte (IDEPA), CONICET, Universidad Nacional del Comahue, Neuquén, Argentina, and others)pp. 217-260

Chapter 12. The Placental Renin Angiotensin System
(Kirsty G. Pringle and Eugenie R. Lumbers, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia)pp. 261-288

Chapter 13. Relationship between Placenta Preeclampsia and the Long Term Clinical Outcome in Adult Offspring
(Cleofina Bosco, Eugenia Díaz, Rodrigo Gutiérrez, Jaime González and Ramón Rodrigo, Anatomy and Developmental Biology Programme, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Chile, and others)pp. 289-310

Chapter 14. Mitochondrial ATP-Diphosphohydrolase and Steroidogenesis in the Human Placenta
(Oscar Flores-Herrera, Sofía Olvera-Sánchez, Juan Pablo Pardo and Federico Martínez, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico)pp. 311-326

Chapter 15. Characterization and Clinical Application of Mesenchymal Stem Cells Derived from Placenta
(Jin-fang Zhang, Wei-ming Fu, Gang Lu and Hsiang-fu Kung, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, and others)pp. 327-334

Chapter 16. The Role of the Primate Placenta in Term and Preterm Parturition
(Roger Smith, Jonathan Paul, Cheng Chan, and Jeffrey Keelan
Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, Australia)pp. 335-346

Index pp. 347-368

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