The Origin of Diseases

Yun-Chul Hong
Daehakno, Chongno-Gu, Seoul, South Korea

Series: Pain and its Origins, Diagnosis and Treatments
BISAC: MED039000

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While covering human history, civilization, and diseases to reveal why humans are sick with many ailments, this book provides the answers to the questions: “When, why, and how did humans contract all kinds of infectious and chronic diseases?”

The increasing occurrence of chronic diseases such as obesity, diabetes mellitus, asthma and cancer does not simply denote increment in the incidence of diseases, but a pathological phenomenon that reflects the condition of humanity’s current environment.

With humanity’s graduation from the era of hunter-gatherers, infectious diseases and nutritional disorders started to appear at the beginning of the agricultural revolution. Humanity then shifted to an age of chronic diseases such as obesity, diabetes mellitus, asthma, and cancer, as they entered the era of affluence in the wake of the industrial revolution. Moreover, the disease pattern characterized by such chronic diseases is expected to change again soon to a new trend characterized by neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

When contemplating the path of disease development and transition, we should simultaneously consider two aspects of humanity: as a biological being who adapts to his or her surrounding environment, and as a cultural creator who transforms and recreates the environment, because the changes in human behavior have as much impact on the direction of disease transition as our genes and environment do. Therefore, only after we appropriately understand the history, environment, and disease development of humanity will we be able to establish an adequate strategy for coping with diseases. We would have the upper hand if we have a better understanding of the origin of diseases. In five sections, this book shows how to understand such diseases through the intertwined process within the wide framework of human history. (Imprint: Nova Biomedical)

Preface

Overview

Chapter 1. Human Genes and the Environment

Chapter 2. The Eight Key Environmental Factors

Chapter 3. The Eight Key Diseases

Chapter 4. New Callenges

Epilogue

Index

Chapter 1

Cause of Diseases: Not Two but One

[1] Bill Bryson. A Short History of Nearly Everything. Broadway Books. 2003.
[2] Charles Darwin. The Origin of Species. Dongseo Publishing House. 2013.
[3] Dolinoy DC. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr. Rev. 66 Suppl 1:S7-11. 2008.
[4] Wolff GL, Kodell RL, Moore SR, Cooney CA. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mouse. FASEB J. 12 (11):949-57. 1998.
[5] Richard Dawkins. Selfish Gene. Oxford University Press. 2006.

The Agricultural Revolution Opens the Age of Disease

[1] Wikipedia. Isthmus of Panama. http://en.wikipedia.org/wiki/Isthmus_of_Panama. 2013.
[2] Gregory Cochran and Henry Harpending, The 10,000 Year Explosion: How Civilization Accelerated Human Evolution. Basic Books. 2010
[3] Wikipedia. Terra Amata. http://en.wikipedia.org/wiki/Terra_Amata_(archaeological_ site). 2013.
[4] Tony McMichael. Human Frontiers, Environments and Disease – Past Patterns, Uncertain Futures. Cambridge University Press. 2001.
[5] Andrew Chamberlain. Archaeological demography. Hum. Biol. 81(2-3):275-86. 2009
[6] Kim Hill, A.M. Hurtado, R.S. Walker. High adult mortality among Hiwi hunter-gatherers: Implications for human evolution. Journal of Human Evolution 52:443e454. 2007.
[7] Jacob L. Weisdorf. From foraging to farming: explaining the neolithic revolution. Journal of Economic Surveys. 19(4): 561-586. 2005.

What Impact Did Human Migration Have on the Occurrence of Disease?

[1] Tony McMichael. Human Frontiers, Environments and Disease – Past Patterns, Uncertain Futures. Cambridge University Press. 2001.
[2] Jablonski NG. The evolution of human skin coloration and its relevance to health in the modern world. J. R. Coll. Physicians Edinb. 42(1):58-63. 2012.
[3] Jean‐Marie Robine, Siu Lan Cheung, Sophie Le Roy, Herman Van Oyen, François R Herrmann. Report on excess mortality in Europe during summer 2003. EU Community Action Programme for Public Health. 2007.
[4] Entine, Jon. Taboo: Why Black Athletes Dominate Sports and Why We Are Afraid to Talk About It. New York: Public Affairs Press. 2000.
[5] J. Philippe Rushton. Race, Evolution, and Behavior: A life History Perspective. 2nd Special Abridged Edition. University of Western Ontario. 2000.
[6] Jared Diamond. Guns, Germs, and Steel: The Fates of Human Societies. W.W Norton & Company. 1999.

Genes Accused with a False Charge

[1] Jared Diamond. Guns, Germs, and Steel: The Fates of Human Societies. W.W Norton & Company. 1999.
[2] Tony McMichael. Human Frontiers, Environments and Disease – Past Patterns, Uncertain Futures. Cambridge University Press. 2001.
[3] Gregory Cochran and Henry Harpending. The 10,000 Year Explosion: How Civilization Accelerated Human Evolution. Basic Books. 2010.
[4] Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: Genetic interactions create phantom heritability. Proc. Natl. Acad. Sci. USA. 109(4):1193-8. 2012.
[5] Jeck WR, Siebold AP, Sharpless NE. Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell. 11(5):727-31. 2012.
[6] Visscher PM. Sizing up human height variation. Nature Genet. 40:489–490. 2008.
[7] Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 461(7265):747-53. 2009.

Chapter 2

Stumbled Upon a Dilemma in Nutritional Intake

[1] Milton K. Diet and primate evolution. Sci. Amer. 269:86-93. 1993.
[2] Tutin CEG, Fernandez M. Composition of the diet of chimpanzees and comparisons with that of sympatric lowland gorillas in the Lopé Reserve, Gabon. Am. J. Primatol. 30:195-211. 1993.
[3] Peter Ungar. Dental topography and diets of Australopithecus afarensis and early Homo. Journal of Human Evolution. 46:605–622. 2004.
[4] Jane Goodall. In the Shadow of Man. Mariner Books. 2010.
[5] John S. Allen. The Omnivorous Mind: Our Evolving Relationship with Food. Harvard University Press. 2012.
[6] Tony McMichael. Human Frontiers, Environments and Disease – Past Patterns, Uncertain Futures. Cambridge University Press. 2001.
[7] Popovich DG, Jenkins DJA, Kendall CWC, Dierenfeld ES, Carroll RW, Tariq N, Vigden E. The western lowland gorilla diet has implications for the health of humans and other hominoids. J. Nutr. 127:2000-5. 1997.
[8] Denton D, We singer R, Mundy NI, Wicking EJ, Dixon A, Moissan P, Pinged AM, Shade R, Carey D, Ardaillou R, Paillard F, Chapman J, Thillet J, Michel JB. The effect of increased salt intake on blood pressure of chimpanzees. Nature Medicine. 1:1009-16. 1995.
[9] Eaton SB, Eaton SB, Sinclair AJ, Cordain L, Mann NJ. Dietary intake of long chain polyunsaturated fatty acids during the Paleolithic. World Rev. Nutr. Dietet. 83:12-23. 1998.
[10] McHenry HM. How big were early hominids? Evol. Anthropol. 1:15-20. 1992.
[11] Crawford MA, Cunnane SC, Harbige LS. A new theory of evolution: quantum theory. In: Sinclair A, Gibson R, eds. Essential fatty acids and eicosanoids. Amer. Oil Chemists Soc. 1992.
[12] Ethne Barnes. Diseases and Human Evolution. UNM Press. 2007.
[13] Cordain L, Eaton SB, Miller JB, Mann N, Hill K. The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic. Eur. J. Clin. Nutr. 56 Suppl 1:S42-52. 2002.
[14] Cohen MN. Health and the rise of civilization. Yale Univ Press. 1989.
[15] Jared Diamond. The Worst Mistake in the History of the Human Race. Discover. 8:64-66. 1987.
[16] Gregory Cochran and Henry Harpending, The 10,000 Year Explosion: How Civilization Accelerated Human Evolution. Basic Books. 2010.
[17] Eaton SB. Fibre intake in prehistoric times. In: Leeds AR, ed. Dietary fibre perspectives. John Libbey. 1990.

Climate Change Lurking behind the Emergence of Disease

[1] Global greenhouse warming. Ice age and sea levels. http://www.global-greenhouse-warming.com/ice-ages-and-sea-levels.html. 2013.
[2] Wikipedia. Ice Age. http://en.wikipedia.org/wiki/Ice_age. 2013.
[3] Wikipedia. Early human migration. http://en.wikipedia.org/wiki/Early_human_
migrations. 2013.
[4] Wikipedia. Green house gas. http://en.wikipedia.org/wiki/Greenhouse_gas#cite_note-63. 2013.
[5] Wikipedia. Keeling curve. http://en.wikipedia.org/wiki/Keeling_Curve. 2013.
[6] Working group to the 4th Assessment Report of the IPCC. Climate Change 2007: Synthesis Report. An Assessment of the Intergovernmental Panel on Climate Change. WMO and UNEP.2007.
[7] Kyle Clendinning. Climate Change and Conflict: The Implications for Sub-Saharan Africa. http://earthreform.org/climate-change-and-conflict-the-implications-for-sub-saharan-africa. 2013.
[8] McMichael AJ. Globalization, climate change, and human health. N. Engle J. Med. 369(1):96. 2013.
[9] Tony McMichael. Human Frontiers, Environments and Disease – Past Patterns, Uncertain Futures. Cambridge University Press. 2001.
[10] Virginia Gewin. Climate change will hit genetic diversity. Nature. doi:10.1038/ news.2011.490. 2011.
[11] Pauls SU, Nowak C, Bálint M, Pfenninger M. The impact of global climate change on genetic diversity within populations and species. Mol. Ecol. 22(4):925-46. 2013.

Is Sunlight Responsible for the Spread of Chronic Diseases?

[1] Kalla AK. Human Skin Colour, Its Genetics, Variation ad Adaptation: A Review. Anthropologist. Special Volume 3:209-214. 2007.
[2] Off MK, Steindal AE, Porojnicu AC, Juzeniene A, Vorobey A, Johnsson A, Moan J. Ultraviolet photo-degradation of folic acid. J. Photochem. Photobiol. B. 80(1):47-55. 2005.
[3] Rogers AR, Iltis D, Wooding S. Genetic Variation at the MC1R Locus and the Time since Loss of Human Body Hair. Current Anthropology. 45:105–8. 2004.
[4] Gregory Cochran and Henry Harpending, The 10,000 Year Explosion: How Civilization Accelerated Human Evolution. Basic Books. 2010.
[5] Edwards M, Bigham A, Tan J, Li S, Gozdzik A, Ross K, Jin L, Parra EJ. Association of the OCA2 Polymorphism His615Arg with Melanin Content in East Asian Populations: Further Evidence of Convergent Evolution of Skin Pigmentation. PLoS Genetics. 6(3): e1000867. doi:10.1371/journal.pgen.1000867. 2010.
[6] Namgung R, Tsang RC. Bone in the pregnant mother and newborn at birth. Clin. Chim. Acta. 333(1):1-11. 2003.
[7] Grant WB, Holick MF. Benefits and Requirements of Vitamin D for Optimal Health: A Review. Alternative Medicine Review. 10(2):94-111. 2005.
[8] Garland CF, Garland FC. Do Sunlight and vitamin D reduce the likelihood of colon cancer? Int. J. Epidemiol. 9:227-231. 1980.
[9] Hong SP, Kim MJ, Jung MY, Jeon H, Goo J, Ahn SK, et al. Biopositive effects of low-dose UVB on epidermis: coordinate up regulation of antimicrobial peptide sand permeability barrier reinforcement. J. Invest. Dermatol. 128:2880-7. 2008.
[10] Campbell GR, Spector SA. Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection. J. Biol. Chem. 286(21):18890-902. 2011.
[11] Glade MJ. Vitamin D: health panacea or false prophet? Nutrition. 29(1):37-41. 2013.
[12] Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC. Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis. J. Korean Med. Sci. 27(6):653-60. 2012.

Since When Have Humans Been Good at Long-Distance Running?

[1] Chakravarty EF, Hubert HB, Lingala VB, Fries JF. Reduced disability and mortality among aging runners: a 21-year longitudinal study. Arch. Intern. Med. 168(15):1638-46. 2008
[2] Alexander RM. Energy-saving mechanisms in walking and running. J. Exp. Biol. 160:55-69. 1991
[3] Jae Allen. What Is the Difference Between Walking & Running Strides? http:// www.livestrong.com/article/364340-what-is-the-difference-between-walking-running-strides/. 2011
[4] Daniel E. Lieberman and Dennis M. Bramble. The Evolution of Marathon Running Capabilities in Humans. Sports Med. 37 (4.6): 288-290. 2007
[5] David R. Carrier, A. K. Kapoor, Tasuku Kimura, Martin K. Nickels, Satwanti, Eugenie C. Scott, Joseph K. So, Erik Trinkaus. The Energetic Paradox of Human Running and Homonid Evolution. Current Anthropology. 25(4):483-495. 1984
[6] van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U S A. 96(23): 13427-31. 1999
[7] Wikipedia. Persistent Hunting. http://en.wikipedia.org/wiki/Persistence_hunting. 2013
[8] O'Keefe JH, Patil HR, Lavie CJ. Exercise and life expectancy. Lancet. 379(9818):799. 2012
[9] Maron BJ, Poliac LC, Roberts WO. Risk for sudden cardiac death associated with marathon running. J. Am. Coll. Cardiol. 28(2):428-31. 1996
[10] Anil Ananthaswamy. Why Is Exercise Such a Chore? Human evolution made us long-distance runners, but it didn’t make us like it. http://www.slate.com/articles/health_
and_science/new_scientist/2013/06/daniel_lieberman_long_distance_running_we_evolved_endurance_and_dislike.html 2014

Alcohol: Its Dual Role

[1] Wikepedia. History of alcoholic beverages. http://en.wikipedia.org/wiki/
History_of_alcoholic_beverages. 2013.
[2] David J. Hanson. Preventing Alcohol Abuse: Alcohol, Culture and Control. Praeger Publishers. 1995.
[3] Patrick E. McGovern. Ancient Wine: The Search for the Origins of Viniculture. Princeton University Press. 2003.
[4] Jean-Charles Sournia, Nick Hindley, Gareth Stanton. A History of Alcoholism. Blackwell Pub. 1990.
[5] David J. Hanson. History of Alcohol and Drinking around the World. http://www2.potsdam.edu/hansondj/Controversies/1114796842.html. 2013.
[6] Jang In Shik. A Story on Beverages. Kimunsa Publishing Co. 2005.
[7] Goedde HW, Harada S, Agarwal DP. Racial differences in alcohol sensitivity: A new hypothesis. Human Genetics. 51(3):331-334. 1979.
[8] Eng MY, Luczak SE, Wall TL. ALDH2, ADH1B, and ADH1C genotypes in Asians: A literature review. Alcohol research & health. 30(1): 22–7. 2007.
[9] Baan R, Straif K, Grosse Y, Secretan B, Ghissassi FE, Bouvard V, et al. Carcinogenicity of alcoholic beverages. The Lancet Oncology. 8(4):292–293. 2007.
[10] B. Simini. Serge Renaud: from French paradox to Cretan miracle. The Lancet. 355 (9197):48. 2000.
[11] Ferreira MP, Willoughby D. Alcohol consumption: the good, the bad, and the indifferent. Appl. Physiol. Nutr. Metab. 33(1):12-20. 2008.

Our Body Has Yet to Adapt to Cigarettes

[1] Wikipedia. History of smoking. http://en.wikipedia.org/wiki/History_of_smoking. 2013
[2] Jordan Goodman. The Tobacco in History: The Cultures of dependence. Routledge. 1995.
[3] Wikipedia. Rodrigo de Jerez. http://en.wikipedia.org/wiki/Rodrigo_de_Jerez. 2013.
[4] Cures for the Plague. http://www.historylearningsite.co.uk/cures_plague_1665.htm. 2015.
[5] David S. Wilkie and Gilda A. Morelli. Forest Foragers: A Day in the Life of Efe Pygmies in the Democratic Republic of Congo. http://www.culturalsurvival.org/
ourpublications/csq/article/forest-foragers-a-day-life-efe-pygmies-democratic-republic-congo. 2015.
[6] Noel T. Boaz. Evolving Health: The Origins of Illness and How the Modern World is Making Us Sick. John Wiley & Sons. 2002.
[7] James T. Patterson. The Dread Disease: Cancer and Modern American Culture. Harvard University Press. 1987.
[8] Wynder E and Graham E. Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma: A study of six hundred and eighty-four proved cases. JAMA. 143:329-336. 1950.
[9] Doll R and Hill AB. Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors. British Medical Journal. 2(5001):1071–1081. 1956.
[10] Saah T. The evolutionary origins and significance of drug addiction. Harm Reduct. J. 29(2):8. 2005.
[11] Yokota J, Shiraishi K, Kohno T. Genetic basis for susceptibility to lung cancer: Recent progress and future directions. Adv. Cancer Res. 109:51-72. 2010.

The Industrial Revolution, a Hotbed for All Sorts of Diseases

[1] Tony McMichael. Human Frontiers, Environments and Disease – Past Patterns, Uncertain Futures. Cambridge University Press. 2001.
[2] Simon Szreter. Industrialization and health. Br. Med. Bull. 69:75-86. 2004.
[3] Thomas McKeown. The Modern Rise of Population. Academic Press. 1976.
[4] Bingham P, Verlander NQ, Cheal MJ. John Snow, William Farr and the 1849 outbreak of cholera that affected London: a reworking of the data highlights the importance of the water supply. Public Health. 118(6):387-94. 2004.
[5] George Kazantzis. Occupational disease. Encyclopedia Britannica.
http://www.britannica.com/EBchecked/topic/424257/occupational-disease. 2015.
[6] Brown JR and Thornton JL. Percivall Pott (1714-1788) and Chimney Sweepers' Cancer of the Scrotum. Br J Ind Med. 14(1): 68–70. 1957
[7] Wikipedia. Thomas Robert Malthus. http://en.wikipedia.org/wiki/Thomas_Robert_ Malthus. 2015.
[8] Fritz Haber. The synthesis of ammonia from its elements. Nobel Lecture.
http://www.nobelprize.org/nobel_prizes/chemistry/laureates/1918/haber-lecture.pdf. 1920.
[9] Tom Standage. An Edible History of Humanity. Walker & Company. 2010.
[10] Joel Mokyr. The Second Industrial Revolution, 1870-1914. The Lever of Riches. 1990
[11] Edward Broughton. The Bhopal disaster and its aftermath: a review. Environ. Health. 4: 6. 2005.
[12] Roger Ekirch. At Day’s Close: Night in Times Past. W. W. Norton& Company Ltd. 2005.
[13] Androniki Naska, Eleni Oikonomou, Antonia Trichopoulou, Theodora Psaltopoulou, Dimitrios Trichopoulos. Siesta in Healthy Adults and Coronary Mortality in the General Population. Arch. Intern. Med. 167(3):296-301. 2007.

The Fatal Legacy of the Use of Fossil Fuels

[1] Park HY, Bae S, Hong YC. PM10 exposure and non-accidental mortality in Asian populations: a meta-analysis of time-series and case-crossover studies. J. Prev. Med. Public Health. 46(1):10-8. 2013.
[2] Kim BJ, Seo JH, Jung YH, Kim HY, Kwon JW, Kim HB, Lee SY, Park KS, Yu J, Kim HC, Leem JH, Lee JY, Sakong J, Kim SY, Lee CG, Kang DM, Ha M, Hong YC, Kwon HJ, Hong SJ. Air pollution interacts with past episodes of bronchiolitis in the development of asthma. Allergy. 68(4):517-23. 2013.
[3] Kim JH, Hong YC. GSTM1, GSTT1, and GSTP1 polymorphisms and associations between air pollutants and markers of insulin resistance in elderly Koreans. Environ. Health Perspect. 120(10):1378-84. 2012.
[4] World Health Organization. Burden of disease from the join effects of Household and Ambient Air Pollution for 2012. http://www.who.int/phe/health_topics/outdoorair/
databases/AP_jointeffect_BoD_results_March2014.pdf?ua=1. 2014.
[5] Roy JR, Chakraborty S, Chakraborty TR. Estrogen-like endocrine disrupting chemicals affecting puberty in humans–a review. Med. Sci. Monit. 15(6):RA137-45. 2009.
[6] Yum T, Lee S, Kim Y. Association between precocious puberty and some endocrine disruptors in human plasma. J. Environ. Sci. Health A Tox Hazard Subst. Environ. Eng. 48(8):912-7. 2013.
[7] Skinner MK, Anway MD. Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors. Ann. N. Y. Acad. Sci. 1061:18-32. 2005.
[8] Dietert RR. Misregulated inflammation as an outcome of early-life exposure to endocrine-disrupting chemicals. Rev. Environ. Health. 27(2-3):117-31. 2012.
[9] Gaspari L, Paris F, Jandel C, Kalfa N, Orsini M, Daures JP, Sultan C. Prenatal environmental risk factors for genital malformations in a population of 1442 French male newborns: a nested case-control study. Hum. Reprod. 26(11):3155-62. 2011.
[10] Fernandez MF, Olmos B, Granada A, Lopez-Espinosa MJ, Molina-Molina JM, Fernandez JM, Cruz M, Olea-Serrano F, Olea N. Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study. Environ. Health Perspect. 115 Suppl 1:8-14. 2007.
[11] Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL; Study for Future Families Research Team. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ. Health Perspect. 113(8):1056-61. 2005.
[12] Kim Y, Ha EH, Kim EJ, Park H, Ha M, Kim JH, Hong YC, Chang N, Kim BN. Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children's Environmental Health (MOCEH) study. Environ. Health Perspect. 119(10):1495-500. 2011.

Chapter 3

Full-Fledged Invasion of Pathogens

[1] Wikipedia. Black Death. http://en.wikipedia.org/wiki/Black_Death. 2013.
[2] Jared Diamond. Guns, Germs, and Steel: The Fates of Human Societies. W.W Norton & Company. 1999.
[3] George J. Armelagos and Kristin N. Harper. Disease Globalization in the Third Epidemiological Transition. Globalization, Health, and the Environment. AltaMira Press. 2005.
[4] Eric Chivian and Aaron Bernstein. Sustaining Life- How Human Health Depends on Biodiversity. Oxford University. 2008.
[5] Harvard University Library Open Collections Program. Contagion- Historical views of diseases and epidemics. http://ocp.hul.harvard.edu/contagion/panamacanal.html. 2013.
[6] Greg Guest and Eric C. Jones. Globalization, Health, and the Environment: An Introduction. Globalization, Health, and the Environment. AltaMira Press. 2005.

We Are Programmed to Gain Weight

[1] Ezzati M and Riboli E. Behavioral and dietary risk factors for noncommunicable diseases. N. Engl. J. Med. 369(10):954-64. 2013.
[2] Cheryl D. Fryar, Margaret D. Carroll, Cynthia L. Ogden. Division of Health and Nutrition Examination Surveys. Prevalence of Overweight, Obesity, and Extreme Obesity Among Adults: United States, Trends 1960–1962 Through 2009–2010. Centers for Disease Control and Prevention. 2012.
[3] Puoane T, Steyn K, Bradshaw D, Laubscher R, Fourie J, Lambert V, Mbananga N. Obesity in South Africa: the South African demographic and health survey. Obes. Res. 10(10):1038-48. 2002.
[4] Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 16:2323–2330. 2008.
[5] Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. (Lond.)32:1431–1437. 2008.
[6] Michael Curtis. The Obesity Epidemic in the Pacific Islands. Journal of Development and Social Transformation. http://www.maxwell.syr.edu/uploadedFiles/moynihan/ dst/curtis5.pdf. 2013.
[7] Jeremy Rifkin, Beyond Beef: The Rise and Fall of the Cattle Culture. Plume. 1993.
[8] Sharon S Elliott, Nancy L Keim, Judith S Stern, Karen Teff, Peter J Havel. Fructose, weight gain, and the insulin resistance syndrome. Am. J. Clin. Nutr. 76:911–22. 2002.
[9] Ann Simmons. Where fat is a mark of beauty. Los Angeles Times. http://www. anthroprof.org/documents/docs102/102articles/fat26.pdf. 1998.
[10] Sylvia Kirchengast. Gender Differences in Body Composition from Childhood to Old Age: An Evolutionary Point of View. J. Life Sci. 2(1):1-10. 2010.
[11] Walley AJ, Asher JE, Froguel P. The genetic contribution to non-syndromic human obesity. Nat. Rev. Genet. 10(7):431-42. 2009.
[12] Fox CS, Pencina MJ, Heard-Costa NL, Shrader P, Jaquish C, O'Donnell CJ, Vasan RS, Cupples LA, D'Agostino RB. Trends in the association of parental history of obesity over 60 years. Obesity (Silver Spring). 22(3):919-24. 2014.

Causes of the Epidemic Spread of Diabetes Mellitus

[1] International Diabetes Federation. The Global Burden. http://www.idf.org/ diabetesatlas/5e/the-global-burden. 2014.
[2] Tosha Dupras et al. Pathological skeletal remains from ancient Egypt: the earliest case of diabetes mellitus? Practical Diabetes Int. 27(8):358-363. 2010.
[3] Jacek Zajac et al. “The Main Events in the History of Diabetes Mellitus”, in Principles of Diabetes. Springer Science+Business Media. 2010.
[4] Laios K, Karamanou M, Saridaki Z, Androutsos G. Aretaeus of Cappadocia and the first description of diabetes. Hormones (Athens). 11(1):109-13. 2012.
[5] Frank LL. Diabetes mellitus in the texts of old Hindu medicine (Charaka, Susruta, Vagbhata). Am. J. Gastroenterol. 27(1):76-95. 1957.
[6] Patti ME and Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr. Rev. 31(3):364-95. 2010.
[7] Drong AW, Lindgren CM, McCarthy MI. The genetic and epigenetic basis of type 2 diabetes and obesity. Clin. Pharmacol. Ther. 92(6):707-15. 2012.
[8] C Nicholas Hales and David J P Barker. The thrifty phenotype hypothesis. British Medical Bulletin 60:5–20. 2001.
[9] Thurner S, Klimek P, Szell M, Duftschmid G, Endel G, Kautzky-Willer A, Kasper DC. Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century. Proc. Natl. Acad. Sci. USA. 110(12):4703-7. 2013.
[10] Taylor KW, Novak RF, Anderson HA, Birnbaum LS, Blystone C, Devito M, Jacobs D, K Charlie J, Lee DH, Rylander L, Rignell-Hydbom A, Tornero-Velez R, Turyk ME, Boyles AL, Thayer KA, Lind L. Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review. Environ Health Perspect. 121(7):774-83. 2013
[11] Lee DH. Persistent organic pollutants and obesity-related metabolic dysfunction: focusing on type 2 diabetes. Epidemiol Health. 34:e2012002. 2012.
[12] Kim JH, Hong YC. GSTM1, GSTT1, and GSTP1 polymorphisms and associations between air pollutants and markers of insulin resistance in elderly Koreans. Environ Health Perspect. 120(10):1378-84. 2012.
[13] Lai MS, Hsueh YM, Chen CJ, Shyu MP, Chen SY, Kuo TL, Wu MM, Tai TY. Ingested inorganic arsenic and prevalence of diabetes mellitus. Am. J. Epidemiol. 139(5):484-92. 1994.
[14] Neel BA and Sargis RM. The paradox of progress: environmental disruption of metabolism and the diabetes epidemic. Diabetes. 60(7):1838-48. 2011.
[15] Chemical industry vision 2030: A European Perspective. https://www.atkearney. com/paper/-/asset_publisher/dVxv4Hz2h8bS/content/chemical-industry-vision-2030-a-european-perspective/10192. 2014.

Variation in the Risk of Hypertension by Region

[1] Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J. Hypertens. 22(1):11-9. 2004.
[2] Gurven M, Blackwell AD, Rodriguez DE, Stieglitz J, Kaplan H. Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists. Hypertension. 60(1):25-33. 2012.
[3] Gurven M, Kaplan H, Winking J, Eid Rodriguez D, Vasunilashorn S, Kim JK, FinchC, Crimmins E. Inflammation and infection do not promote arterial aging and cardiovascular disease risk factors among lean horticulturalists. PLoS One. 4(8):e6590. 2009.
[4] Michael R. Eades. Obesity in ancient Egypt. http://www.proteinpower.com/
drmike/obesity/obesity-in-ancient-egypt/. 2007.
[5] Thompson EE, Kuttab-Boulos H, Witonsky D, Yang L, Roe BA, Di Rienzo A. CYP3A variation and the evolution of salt-sensitivity variants. Am. J. Hum. Genet. 75(6):1059-69. 2004.
[6] Kaufman JS, Durazo-Arvizu RA, Rotimi CN, McGee DL, Cooper RS. Obesity and hypertension prevalence in populations of African origin. The Investigators of the International Collaborative Study on Hypertension in Blacks. Epidemiology. 7(4):398-405. 1996.
[7] National Institutes of Health. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). U.S. Department of Health and Human Services. 2004.
[8] Taal HR, Verwoert GC, Demirkan A, Janssens AC, Rice K, Ehret G, Smith AV, Verhaaren BF, Witteman JC, Hofman A, Vernooij MW, Uitterlinden AG, Rivadeneira F, Ikram MA, Levy D, van der Heijden AJ; Cohort for Heart and Aging Research in Genome Epidemiology and Early Genetics and Lifecourse Epidemiology consortia, Jaddoe VW, van Duijn CM. Genome-wide profiling of blood pressure in adults and children. Hypertension. 59(2):241-7. 2012.

Once a Beneficial Gene, Now a Culprit for Cardiovascular Diseases

[1] Lemogoum D, Ngatchou W, Janssen C, Leeman M, Van Bortel L, Boutouyrie P, Degaute JP, Van de Borne P. Effects of hunter-gatherer subsistence mode on arterial distensibility in Cameroonian pygmies. Hypertension. 60(1):123-8. 2012.
[2] O'Dea K. Cardiovascular disease risk factors in Australian aborigines. Clin. Exp. Pharmacol. Physiol. 18(2):85-8. 1991.
[3] James Owen. Egyptian Princess Mummy Had Oldest Known Heart Disease. http://news.nationalgeographic.com/news/2011/04/110415-ancient-egypt-mummies-princess-heart-disease-health-science/. 2011.
[4] Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing epidemic of coronary heart disease in low- and middle-income countries. Curr. Probl. Cardiol. 35(2):72-115. 2010.
[5] Enos WF, Holmes RH, Beyer J. Coronary disease among United States soldiers killed in action in Korea. JAMA. 152 (12):1090-1093. 1953.
[6] Williams KJ and Tabas I. The Response-to-Retention Hypothesis of Early Atherogenesis. Arteriosclerosis, thrombosis, and vascular biology. 15(5):551–61. 1995.
[7] Ding K and Kullo IJ. Evolutionary genetics of coronary heart disease. Circulation. 119(3):459-67. 2009.
[8] Van Den Biggelaar AH, De Craen AJ, Gussekloo J, Huizinga TW, Heijmans BT, Frölich M, Kirkwood TB, Westendorp RG. Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming. FASEB J. 18(9):1022-4. 2004.
[9] Hahn MW, Rockman MV, Soranzo N, Goldstein DB, Wray GA. Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans. Genetics. 167: 867–877. 2004.
[10] Ding K and Kullo IJ. Evolutionary genetics of coronary heart disease. Circulation. 119(3):459-67. 2009.
[11] Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 8:1–21. 1988.
[12] Eisenberg DTA, Kuzawa CW, Hayes MG. Worldwide allele frequencies of the human apoliprotein E (APOE) gene: climate, local adaptations and evolutionary history. American Journal of Physical Anthropology. 143(1):100–111. 2010.
[13] Jean Davignon, Jeffrey S. Cohn, Laurence Mabile, Lise Bernier. Apolipoprotein E and atherosclerosis: insight from animal and human studies. Clinica Chimica Acta. 286:115–143. 1999.
[14] Shah S, Casas JP, Gaunt TR, Cooper J, Drenos F, Zabaneh D, Swerdlow DI, ShahT, Sofat R, Palmen J, Kumari M, Kivimaki M, Ebrahim S, Smith GD, Lawlor DA, Talmud PJ, Whittaker J, Day IN, Hingorani AD, Humphries SE. Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur. Heart J. 34(13):972-81. 2013.
[15] Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: epidemiology and possible mechanisms. J. Am. Dent. Assoc. 133Suppl:14S-22S. 2002.
[16] Pal S, Radavelli-Bagatini S, Ho S. Potential benefits of exercise on blood pressure and vascular function. J. Am. Soc. Hypertens. S1933-1711(13). 2013.
[17] Black PH. The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav. Immun. 17(5):350-64. 2003.
[18] Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD. Long-term exposure to air pollution and incidence of cardiovascular events in women. N. Engl. J. Med. 356(5):447-58. 2007.
[19] Chandola T, Ferrie JE, Perski A, Akbaraly T, Marmot MG. The effect of short sleep duration on coronary heart disease risk is greatest among those with sleep disturbance: a prospective study from the Whitehall II cohort. Sleep. 33(6):739-44. 2010.

Immature Defense System Causes Allergic Diseases

[1] Allergy Associates of Utah. Allergies in Utah and Around the World- A Historical Perspective. http://www.utahallergies.com/allergy-info/allergy-information/allergy-history.html. 2013.
[2] Richard Wagner. Clemens von Pirquet, discoverer of the concept of allergy. Bull N Y Acad Med. 40(3):229-235. 1964.
[3] Estelle Simons. Ancestors of allergy. Global Medical Communications. 1994.
[4] Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI; ISAAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J. Allergy Clin. Immunol. 124(6):1251-8. 2009.
[5] Robertson CF, Heycock E, Bishop J, Nolan T, Olinsky A, Phelan PD. Prevalence of asthma in Melbourne schoolchildren: changes over 26 years. BMJ. 302:1116-8. 1991.
[6] Bisgaard H, Simpson A, Palmer CN, Bnnelykke K, McLean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A. Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med. 5(6):e131. 2008.
[7] Williams HC. Epidemiology of human atopic dermatitis–seven areas of notable progress and seven areas of notable ignorance. Vet. Dermatol. 24(1):3-9. 2013.
[8] Tezza G, Mazzei F, Boner A. Epigenetics of allergy. Early Hum. Dev. 89 Suppl 1:S20-1. 2013.
[9] Waltraud Eder, Markus J. Ege, Erika von Mutius. Asthma Epidemic. N. Engl. J. Med. 355:2226-35. 2006.
[10] Strachan DP and Cook DG. Parental smoking and childhood asthma: longitudinal and case-control studies. Thorax. 53:204-12. 1998.
[11] Schaub B and von Mutius E. Obesity and asthma, what are the links? Curr. Opin. Allergy Clin. Immunol. 5:185-93. 2005.

Cancer: A Purely Man-made Disease

[1] Shi-Ming Tu. “Origin of Cancers” in Cancer Treatment and Research. Springer. 2010
[2] Rosalie David and Michael R. Zimmerman. Cancer: an old disease, a new disease or something in between? Nature Reviews Cancer. 10:728-733. 2010
[3] Noel Boaz. The origin of illness and how the modern world is making us sick. John Wiley & Sons. 2002
[4] Kobayashi H, Ohno S, Sasaki Y, Matsuura M. Hereditary breast and ovarian cancer susceptibility genes (Review). Oncol. Rep. 30(3):1019-29. 2013
[5] International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. WHO. http://monographs.iarc.fr/. 2014
[6] Parkin DM. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br. J. Cancer. 105 Suppl 2:S2-5. 2011

Modern Society Prompts Depression

[1] World Health Organization. Global burden of mental disorders and the need for a comprehensive, coordinated response from health and social sectors at the country level. http://apps.who.int/gb/ebwha/pdf_files/EB130/B130_9-en.pdf. 2011.
[2] Amber Hague. Psychology from Islamic Perspective: Contributions of Early Muslim Scholars and Challenges to Contemporary Muslim Psychologists. Journal of Religion & Health. 43(4):357-377. 2004.
[3] Berrios GE. Melancholia and depression during the 19th century: a conceptual history. The British Journal of Psychiatry. 153:298-304. 1988.
[4] Paul W. Andrews and J. Anderson Tompson, Jr. Depression’s Evolutionary Roots. Scientific American. August 2009.
[5] Michael J. Raleigh, Michael T. McGuire, Gary L. Brammer, Arthur Yuwiler. Social and Environmental Influences on Blood Serotonin Concentrations in Monkeys. Arch. Gen. Psychiatry. 41(4):405-410. 1984.
[6] Wikipedia. Creativity and mental illness. http://en.wikipedia.org/wiki/Creativity_ and_mental_illness. 2013.
[7] Hamazaki K, Itomura M, Huan M, Nishizawa H, Sawazaki S, Tanouchi M, WatanabeS, Hamazaki T, Terasawa K, Yazawa K. Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial. Nutrition. 21(6):705-10. 2005.
[8] John A. Wagner and John R. Hollenbeck. Organizational Behavior: Securing Competitive Advantage. Routledge. 2015.

Chapter 4

Beyond the Age of Chronic Diseases

[1] World Health Organization. The global burden of disease: 2004 update. http://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/. 2008.
[2] Tunstall-Pedoe H, Kuulasmaa K, Mähönen M, Tolonen H, Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet. 353(9164):1547-57. 1999.
[3] National Cancer Institute. Cancer Trends Progress Report – 2011/2012 Update. http://progressreport.cancer.gov. 2012.
[4] Department of Health & Human Services. USA. Healthy People 2020 Leading Health Indicators: Progress Update. https://www.healthypeople.gov/sites/default/files/LHI-ProgressReport-ExecSum_0.pdf. 2014.

How Long Can We Expect to Live?

[1] Yoo Dong Kim. Civilization in the Alluvial Epoch. Publishing House Gil. 2011.
[2] Kaare Christensen, Gabriele Doblhammer, Roland Rau, James W Vaupel. Ageing populations: the challenges ahead. Lancet. 374:1196-208. 2009.
[3] Tony McMichael. Human frontiers, environments and disease: Past patterns, uncertain futures. Cambridge University Press. 2001.
[4] Friedman DB and Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 118(1):75-86. 1988.
[5] Kenyon C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 366(1561):9-16. 2011.
[6] Moore SC, Patel AV, Matthews CE, Berrington de Gonzalez A, Park Y, Katki HA, Linet MS, Weiderpass E, Visvanathan K, Helzlsouer KJ, Thun M, Gapstur SM, Hartge P, Lee IM. Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis. PLoS Med. 9(11):e1001335. 2012.
[7] Streppel MT, Ocké MC, Boshuizen HC, Kok FJ, Kromhout D. Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study. J. Epidemiol. Community Health. 63(7):534-40. 2009
[8] Augusto Di Castelnuovo, Simona Costanzo, Vincenzo Bagnardi, Maria Benedetta Donati, Licia Iacoviello, Giovanni de Gaetano. Alcohol Dosing and Total Mortality in Men and Women: An Updated Meta-analysis of 34 Prospective Studies. Arch. Intern. Med. 166:2437-2445. 2006.
[9] Prabhat Jha, Chinthanie Ramasundarahettige, Victoria Landsman, Brian Rostron, Michael Thun, Robert N. Anderson, Tim McAfee, Richard Peto. 21st-Century Hazards of Smoking and Benefits of Cessation in the United States. N. Engl. J. Med. 368;4. 2013.
[10] Michael J. Thun, Brian D. Carter, Diane Feskanich, Neal D. Freedman, Ross Prentice, Alan D. Lopez, Patricia Hartge, Susan M. Gapstur. 50-Year Trends in Smoking-Related Mortality in the United States. N. Engl. J. Med. 368;4 2013.
[11] David L. Wilson. “Evolution and Experiment Show the Way” in Reducing Human Aging: Clues from How and Why We Age. http://www.bio.miami.edu/dwilson/ Chapt6.pdf. 2008.
[12] Nick Lane. Life Ascending: The Ten Great Inventions of Evolution. Geulhangari Publishers. 2008.
[13] Neill D. Life's timekeeper. Ageing Res. Rev. 12(2):567-78. 2013.
[14] Schoenhofen EA, Wyszynski DF, Andersen S, Pennington J, Young R, Terry DF, Perls TT. Characteristics of 32 supercentenarians. J. Am. Geriatr. Soc. 54(8):1237-40. 2006.

Aging-related Disease, a Price to Pay

[1] United Nations. World Population Ageing 2013. http://www.un.org/en/development/ desa/population/publications/pdf/ageing/WorldPopulationAgeing2013.pdf. 2013.
[2] Shaw-Smith C, Pittman AM, Willatt L, Martin H, Rickman L, Gribble S, Curley R, Cumming S, Dunn C, Kalaitzopoulos D, Porter K, Prigmore E, Krepischi-Santos AC, Varela MC, Koiffmann CP, Lees AJ, Rosenberg C, Firth HV, de Silva R, Carter NP. Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability. Nat. Genet. 38(9):1032-7. 2006.
[3] Quilty MC, King AE, Gai WP, Pountney DL, West AK, Vickers JC, Dickson TC. Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. Exp. Neurol. 199(2):249-56. 2006.
[4] Ridge PG, Mukherjee S, Crane PK, Kauwe JS; Alzheimer’s Disease Genetics Consortium. Alzheimer's disease: analyzing the missing heritability. PLoS One. 8(11):e79771. 2013.
[5] Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stefánsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA; International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum. Mol. Genet. 21(22):4996-5009. 2012.
[6] Martínez-García A, Sastre I, Recuero M, Aldudo J, Vilella E, Mateo I, Sánchez-Juan P, Vargas T, Carro E, Bermejo-Pareja F, Rodríguez-Rodríguez E, Combarros O, Rosich-Estrago M, Frank A, Valdivieso F, Bullido MJ. PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease. J. Alzheimers Dis. 22(4):1181-7. 2010.
[7] Cookson M. Evolution of Neurodegeneration. Current Biology. 22(17):R753-761. 2012.
[8] Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 56(3):M146-56. 2001.
[9] Shamliyan T, Talley KM, Ramakrishnan R, Kane RL. Association of frailty with survival: a systematic literature review. Ageing Res. Rev. 12(2):719-36. 2013.
[10] Nick Lane. Power, Sex, Suicide – Mitochondria and the Meaning of Life. Oxford University Press. 2005.
[11] Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J. Cell. Sci. 123(Pt 15):2533-42. 2010.

Amidst the Turning Tide

[1] Natalie D. Munro and Leore Grosman. Early evidence (ca. 12,000 B.P.) for feasting at a burial cave in Israel. PNAS. 107(35):15362-15366. 2010.
[2] Anthony McMichael. Human frontiers, environments and disease: Past patterns, uncertain futures. Cambridge University Press. 2001.
[3] Cardis E, Krewski D, Boniol M, Drozdovitch V, Darby SC, Gilbert ES, Akiba S, Benichou J, Ferlay J, Gandini S, Hill C, Howe G, Kesminiene A, Moser M, Sanchez M, Storm H, Voisin L, Boyle P. Estimates of the cancer burden in Europe from radioactive fallout from the Chernobyl accident. Int. J. Cancer. 119(6):1224-35. 2006.

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