The Optimization of Drug Prescribing in Children

Hugo Juárez-Olguín (Editor)
Laboratorio de Farmacología, Instituto Nacional de Pediatría, Mexico City, Mexico
CIIDIR, Durango, Mexico

Series: Pediatrics – Laboratory and Clinical Research
BISAC: MED069000

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Pediatrics is the form of medical care that is concerned with children from birth to adolescence, specializing in a variety of characteristics and changes subjective to each patient. Undoubtedly, these changes influence drug distribution and response. The body composition and the processes of biological and physiological maturation constitute important variables worthy of consideration in the effort to adequately satisfy the therapeutic necessities of all the age groups, since different formulations are required to achieve optimum therapy.
The technological advances in the last decades have endowed humanity with the facilities to painstakingly analyze biological samples and thus give way to potential progress in pharmacokinetics and pharmacodynamics. From this knowledge, it becomes clear that the body is a dynamic model and thus, brings to light the necessity to individualize treatment regimens based on parameters of each and every individual, which in the past was not as important.

There are instruments that contribute to optimizing drug management and safety in the pediatric population as recommended by the World Health Organization that rotate on the application of drug monitoring strategies that would contribute to ensuring the safety of patients and improve treatment schemes with increasingly safe and effective drugs. Furthermore, recourses to the therapeutic monitoring of drugs would become available where a monitoring based principally on the drug plasma levels is carried out in order to make the pertinent dose adjustments. The need for this will arise, since the most effective therapeutic range of many drugs is still unknown; unnecessarily high concentrations with potential risks of producing toxicity in patients is something that must be avoided.
With these factors in mind, the decision to compose this book for pediatric doctors as well as specialists in the health sector who are dedicated to childcare became apparent, with the hope of portraying an array of pharmacokinetic knowledge, based on new therapeutic strategies ensuing from information furnished by research. The authors are convinced that the consideration of these concepts would definitely permit the elaboration of optimum and specific treatment for each pediatric patients. (Imprint: Nova Biomedical)

Preface

Acknowledgments

Chapter 1. Pharmacokinetics and Its Clinical Applications (pp. 1-24)
Ismael Lares-Asseff and Hugo Juárez Olguín

Chapter 2. Pharmacokinetic, Growth and Development (pp. 25-50)
Ismael Lares Asseff and Gabriela Pérez Guille

Chapter 3. Main Diseases in Pediatrics (pp. 51-74)
Mayra SantillánGarcía, Monica Punzo Soto and Belen Juárez Tapia

Chapter 4. How Is the LADME Process of Drugs in Children? (pp. 75-90)
Hugo Juárez Olguín, David Calderón Guzmán and Mónica Punzo Soto

Chapter 5. Pharmacology for the Fetus and the Newborn (pp. 91-112)
Hugo Juárez Olguín and Ismael Lares-Asseff

Chapter 6. Pharmacokinetic Principles in the Use of Antibiotics in Pediatrics (pp. 113-132)
María-Gabriela Pérez Guille, Ismael Lares Asseff and Alejandra Toledo López

Chapter 7. Therapeutic Drug Monitoring in Children (pp. 133-154)
Hugo Juárez Olguín, Monica Punzo Soto and Belen Juárez Tapia

Chapter 8. Nutrition and Pharmacokinetics of Medicines (pp. 155-188)
Ismael Lares Asseff, Mayra Santillán García, and Belen Juárez Tapia

Chapter 9. Pharmacovigilance and Pharmacoepidemiology of Drugs in a Pediatric Hospital (pp. 189-202)
Hugo Juárez Olguín, Fernanda Reyes Gonzalez, and Janett Flores Perez

Chapter 10. Unintentional Drug Poisoning in the Pediatric Population (pp. 203-212)
Hugo Juárez Olguín, Carmen Flores Pérez, and Janett Flores Pérez

Chapter 11. Suicidal Attempts by Consumption of Drugs in Children (pp. 213-220)
Mónica Punzo Soto, Carmen Flores Pérez, and Mayra Santillán García

Index (pp. 221)

This book is for pediatric doctors as well as to the specialists in the health sector who are dedicated to childcare.

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