The Optimal Circulation: Cells’ Contribution to Arterial Pressure

Rafik D. Grygoryan
Cybernetics Center of National Academy of Sciences of Ukraine, Kiev, Ukraine

Series: Cell Biology Research Progress
BISAC: SCI017000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Prevailing physiological concepts (PPC) of blood circulation consider the cardiovascular system (CVS) an autonomous system that has its own goal and mechanisms for achieving it. Physiologists agree that complex neural and humoral controllers of a mean arterial pressure (MAP) indirectly alter the blood flow for satisfying cellular needs. However, PPCs are incapable of explaining the causes of long-term shifts of a MAP’s rest level. In particular, this affects the current understanding and cure technologies of arterial hypertension (AH). Considering AH as a disease, physicians seek a cure that effectively decreases the elevated pressure. This gives rise to the palliative cure softening of AH symptoms without an understanding of AH’s primary causes. But this strategy, working until the patient intakes antihypertensive drugs, often leads to AH’s further development, and in extreme cases, current antihypertensive drugs are helpless. These limitations of PPC are forced to seek a circulation’s extended physiological theory (EPT), explaining the mechanisms of both normal and altered MAP’s.

In the EPT presented in the book, CVS is considered a constituent part of a more complex functional super-system (FSS) that appears in a multi-cellular animal organism during the co-evolution of specialized cells. The general goal of FSS is to provide optimal physiochemical and energy states of the cell cytoplasm. To achieve this goal under a stochastic total and local variations of cells’ activity, FSS should control: i) The cardiac output; ii) the regional and local blood flows; and iii) the chemical composition of both arterial and venous blood. Under chronic energy shortage, FSS should also provide an adequate increasing of ATP-synthesis in mitochondria of stagnated cells. So, under the ineffectiveness of current mitochondria, FSS must enrich the arterial blood by chemicals providing the biogenesis of mitochondria. However, neither the energy providers nor the providers of blood chemistry are properly involved in PPC of the blood circulation.

The EPT for the first time integrates the hemodynamic and metabolic aspects of cell life at the organism scale. It is proved that the CVS activity is inversely associated with the activity of mechanisms controlling the rates of both pulmonary ventilation and erythropoiesis. Under significant and chronic energy deficiency, the cells activate additional FSS mechanisms, materially supporting the biogenesis of mitochondria. The activity of FSS mechanisms forming the chemical composition of arterial and venous blood is in reciprocal relationships with the function of CVS. So, the EPT associates the function of CVS with energy and metabolic problems in cells.

The EPT concerns both traditional and additional determinants of the MAP level. It is proved that stochastic combinations of these determinants force the MAP level to “float”. In particular, both the mitochondrial insufficiency and the chemical contamination of cytoplasm are capable of causing AH. The normal arterial pressure is always individual. Before correcting the altered arterial pressure, a complex medical examination for ascertaining the mitochondrial function, the status of the FSS mechanisms is recommended. The diagnosis of AH should be reoriented for detecting cellular abnormalities. The therapy of AH should be targeted at finding strategies for optimizing the entire FSS function. (Imprint: Nova Biomedical)



List of Abbreviations


Chapter 1. Challenges for Survival in Unfavorable Conditions

Chapter 2. Interpretations of the Normal Value of Arterial Pressure

Chapter 3. Primary and Secondary Determinants of Arterial Pressure

Chapter 4. Opportunities and Limitations of Traditional Regulators of the Cardiovascular System

Chapter 5. A Fight of an Aerobic Cell for Energy

Chapter 6. Organism-Scale Enhancers of Stagnated Cells

Chapter 7. A Concept of Physiological Super-Systems

Chapter 8. Disturbers of Mean Arterial Pressure

Chapter 9. How Do the Stagnated Cells Increase Arterial Pressure?

Chapter 10. Circulation in an Evolving Organism





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