The Molecular Basis for the Aging of Human Skin

Taihao Quan
University of Michigan Medical School, USA

Series: Dermatology – Laboratory and Clinical Research
BISAC: MED017000

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Skin is the most voluminous connective tissue of the body. Skin, like all other human organs, undergoes progressive alterations as a consequence of the passage of time (natural aging). However, human skin, unlike other organs, continuously experiences harmful exposure from environmental sources such as solar ultraviolet irradiation (photoaging). As the bulk of the skin is largely comprised of connective tissue collagen, the primary molecular features of aged human skin are reduced production of collagen and accumulation of damaged collagen. Age-related alterations of dermal connective collagen cause an aberrant tissue microenvironment, which deleteriously influence the risk of developing age-related skin diseases. This book comprehensively describes the molecular mechanisms of human skin connective tissue aging by emphasizing age-related dermal microenvironment as a strategy for improving our quality of life as well as for preventive and therapeutic intervention of age-related skin diseases. This book is an essential resource for the development of mechanisms-based anti-skin aging products. (Imprint: Nova Biomedical)

Preface

Chapter 1. Collagen and Human Skin Connective Tissue Aging

Chapter 2. Impaired TGF-â Signaling in Aged Human Skin: The Impact on Thin Dermis

Chapter 3. Elevated Matrix Metalloproteinases (MMPs) in Aged Human Skin: The Impact on Damaged Dermis

Chapter 4. Impaired TGF-â signaling by Age-Related Loss of Fibroblast Size/Shape and Mechanical Tension

Chapter 5. Elevated Matrix Metalloproteinases (MMPs) by Age-Related Loss of Fibroblast Size/Shape and Mechanical Tension

Chapter 6. CCN Family Proteins in Human Skin Connective Tissue Aging

Chapter 7. Oxidative Stress Creates an Age-Associated Dermal Microenvironment (AADM): A Characteristic Feature of Human Skin Connective Tissue Aging

Chapter 8. Age-Related Changes in Physical Properties of Dermal Connective Tissue Collagen in Naturally Aged and Photoaged Human Skin

Chapter 9. Rejuvenation of Aged Human Skin: The Molecular Basis of Retinol Anti-Aging Properties in Human Skin Connective Tissue Aging

Chapter 10. Age-Associated Dermal Microenvironment (AADM) and Age-Related Skin Diseases

Index

Chapter 1

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