The Medulloblastoma Book. Second Edition


Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

This book offers a unique insight into the “medulloblastoma world,” and provides both a broad review and detailed analysis of this brain tumour. It starts with the history of medulloblastoma as a term, and as a distinct entity in nosology, and then explores in depth, the diagnosis, genetics, neurosurgical, and oncological management of medulloblastoma patients, as well as their outcome and long-term complications. Furthermore, novel therapies and next generation clinical trials in medulloblastoma are discussed. This landmark text is written by leading authorities in the research and treatment of medulloblastoma.

It provides information based on clinical trials, major clinical series, and the authors’ outstanding experience and knowledge. It contains numerous, detailed illustrations, which help the reader understand the new knowledge easily. Also, it includes pitfalls and perils of the management of patients with medulloblastoma.

The Medulloblastoma Book is useful to both medical specialists such as paediatricians, radiologists, neurosurgeons, and oncologists who are looking for the latest research in an integrated text, containing the current knowledge about medulloblastoma. This books is also useful for medical students, nurses, residents, and young researchers who are interested in medulloblastoma, neurosurgery, and neuro-oncology.

This text aims to enrich medical literature throughout the world by providing an integrated understanding of medulloblastoma in a comprehensive and practical manner, by being written by scientists working at the cutting-edge of their specialities.
(Imprint: Nova Medicine and Health)

Table of Contents

Table of Contents


Chapter 1. Introduction to Medulloblastoma
(Dimitris A. Kombogiorgas, MD, Department of Neurosurgery, Hygeia Hospital,
Athens, Greece)

Chapter 2. Genetics of Medulloblastoma
(Abhinav Dey, PhD, Anshu Malhotra, PhD, Mwangala Akamandisa, Kai Nie, Anna Marie Kenney, PhD, and Robert Craig Castellino, MD, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, US)

Chapter 3. Imaging of Medulloblastoma
(Korgun Koral, MD, Department of Radiology, University of Texas Southwestern Medical Center and Children’s Medical Center, Dallas, Texas, US)

Chapter 4. Surgical Treatment of Medulloblastoma
(Dimitris A. Kombogiorgas, MD, Department of Neurosurgery, Hygeia Hospital, Athens, Greece, and others)

Chapter 5. Radiotherapy in the Management of Medulloblastoma
(Thankamma Ajithkumar MD, and Gail Horan, Department of Oncology and Pediatric Radiation Oncology, Cambridge University Hospitals, Cambridge, UK)

Chapter 6. Toxicity of Radiotherapy in the Treatment for Medulloblastoma
(Scott Lester, MD, Rachael Lester, MD, and Nadia Laack, MD, Department of Radiation Oncology, Mayo Clinic, Rochester, MN, US)

Chapter 7. Chemotherapy of Medulloblastoma
(Asher M. Marks, MD, Eugene I. Hwang, MD, and Roger J. Packer, MD, Department of Pediatrics, Section of Hematology-Oncology, Yale School of Medicine, New Haven, Connecticut, and others)

Chapter 8. Metastatic Medulloblastoma: Clinical and Biological Insights
(Ana S. Guerreiro Stücklin, MD, PhD, Vijay Ramaswamy, MD, PhD, Marc Remke, MD, Xiaochong Wu, PhD, and Michael D. Taylor, MD, PhD, Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada, and others)

Chapter 9. Medulloblastoma: Outcomes and Long-Term Complications
(Veronica Biassoni, MD, Lorenza Gandola, MD, Ettore Seregni MD, Filippo Spreafico, MD, Elisabetta Schiavello, MD, Carlo Alfredo Clerici, MD, and Maura Massimino, MD, Department of Pediatrics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, and others)

Chapter 10. Medulloblastoma in the Developmental Age: Long-Term Neurocognitive and Emotional Behavioral Outcomes
(Daria Riva, MD, Matilde Taddei, PhD, Silvia Esposito, MD, and Sara Bulgheroni, PsyD, Developmental Neurology Division, Fondazione IRCCS Istituto C. Besta, Milano, Italy)

Chapter 11. Medulloblastoma: Our Experience with Rehabilitation
(Geraldina Poggi, MD, and Maria Chiara Oprandi, Unit of Neuro-Oncology and Neuropsychological Rehabilitation, La Nostra Famiglia, Bosisio Parini, Italy)

Chapter 12. Medulloblastoma in Adulthood
(Laurent Riffaud, MD, PhD, Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France)

Chapter 13. Novel Therapies and Next Generation Clinical Trials in Medulloblastoma
(Ryan K. Mathew MD, Claudia C. Faria, MD, Roberto J. Diaz, MD, PhD, and James T. Rutka, MD, PhD, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Canada, and others)


Neurosurgeons, Neurologist, Oncologists, Radiation Oncologists, Pediatricians, Nurses, Medical Students
Neurosurgical and Neurological Institutions
Pharmaceutical Industry

Keywords: Medulloblastoma, brain tumor, oncology, radiotherapy, chemotherapy, neurosurgery, pediatric oncology, residual tumor, staging, genetics, complications, side effects, outcome

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