The Ketogenic Diet Reexamined: Myth vs. Reality

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Leticia Granados-Rojas, PhD – Researcher in Medical Sciences, Laboratory of Neuroscience II, National Institute of Pediatrics, Mexico City, Mexico
Carmen Rubio, PhD – Researcher in Medical Sciences, Neurophysiology Department, National Institute of Neurology and Neurosurgery, Mexico City, Mexico

Series: Neuroscience Research Progress
BISAC: MED057000; MED021000
DOI: https://doi.org/10.52305/KSTQ4025

This book contains seven chapters that present research on the ketogenic diet and its roles in neuroscience and cancer. Chapter one highlights the roles of the ketogenic diet in neuroprotection and biochemical processes involved in the control of epilepsy. Chapter two reviews the use of the ketogenic diet, a low-carb, high-fat regimen, as an adjuvant treatment for neurological diseases such as Parkinson’s disease. Chapter three discusses how the antioxidant properties of the ketogenic diet might benefit patients by potentially ameliorating the harmful consequences of Alzheimer’s disease. Chapter four examines abnormalities in the different molecular components of the GABAergic system in neuropsychiatric disorders as well as the beneficial effects the ketogenic diet on them. Chapters five and six discuss the ketogenic diet’s role in cancer prevention and neuroglia. Chapter 7 presents the effect of the ketogenic diet on NKCC1 cotransporter regional expression.

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Table of Contents

Preface

Chapter 1. The Molecular Mechanisms of the Ketogenic Diet in Epilepsy
Moisés Rubio-Osornio¹, Rudy Luna², Tarsila Elizabeth Juárez-Zepeda³, Leticia Granados-Rojas³, Leticia Granados-Rojas³, and Carmen Rubio²
¹Department of Neurochemistry, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico City, Mexico
²Department of Neurophysiology, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico
³Neuroscience Laboratory II, National Institute of Pediatrics, Mexico City, Mexico

Chapter 2.
The Role of the Ketogenic Diet on Parkinson’s Disease Symptoms
Joyce Graciela Martínez-Galindo¹, Ana Vigil-Martínez², and Ernesto Ochoa³
¹Dementia Laboratory, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico
²Department of Nutritional Physiology, Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
³Department of Neurophysiology, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico

Chapter 3. The Ketogenic Diet and Alzheimer’s Disease
Ernesto Ochoa¹, Fernando Gatica¹, Zayra Morales¹, Héctor Romo-Parra², Luis Antonio Marín-Castañeda¹,³, and Carmen Rubio
¹Department of Neurophysiology, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico
²Psychology Research Center, Faculty of Psychology, La Salle University, Mexico City, Mexico
³Mexican Faculty of Medicine, La Salle University, Mexico City, Mexico
 
Chapter 4. The Ketogenic Diet in Neuropsychiatric Disorders
Tarsila Elizabeth Juárez-Zepeda¹, Carmen Rubio², Diana Molina-Valdespino³, Luis Antonio Marín-Castañeda²,, America Vanoye Carlo¹, and Leticia Granados-Rojas¹
¹Laboratory II, National Institute of Pediatrics, Mexico City, Mexico
²Department of Neurophysiology, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico
³Mental Health Service, National Institute of Pediatrics, Mexico City, Mexico
Mexican Faculty of Medicine, La Salle University, 
 
Chapter 5. The Ketogenic Diet and Cancer Prevention
Fernando Gatica¹, Noél Gallardo¹, Eric Uribe¹, Diana Flores¹, Vanessa Mena¹, Amalia Alejo²,³, David Vázquez¹, and Carmen Rubio
¹Department of Neurophysiology, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery 
²Pain and Analgesia Laboratory, Department of Pharmacobiology, CINVESTAV South Headquareters, 
³Department of Neurology and Psychiatry, Salvador Zubirán National Institute of Medical Sciences and Nutrition 
 
Chapter 6. The Ketogenic Diet and Neuroglia
Eric Uribe¹, Carmen Rubio¹, Vanessa Mena¹, Noel Gallardo¹, Diana Flores¹, David Vázquez¹, and Moisés Rubio-Osornio²
¹Department of Neurophysiology, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico Ci
²Department of Neurochemistry, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery 
 
Chapter 7. The Regional Expression of NKCC¹ Cotransporter in the Dentate Gyrus of Rats Fed with a Ketogenic Diet
Karina Jerónimo-Cruz¹,², Tarsila Elizabeth Juárez-Zepeda², Joyce Graciela Martínez-Galindo³, Miguel Tapia-Rodríguez , America Vanoye Carlo², and Leticia Granados-Rojas
¹Laboratory of Biochemistry and Endocrinology, National Institute of Pediatrics, Mexico City, Mexico
²Neuroscience Laboratory II, National Institute of Pediatrics, Mexico City, Mexico
³Dementia Laboratory, Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Microscopy Unit, Biomedical Research Institute, National Autonomous University of Mexico, Mexico City, Mexico

Index


Editor’s ORCID iD

Carmen Rubio: 0000-0002-4775-5043

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