The Future of Metabolic Engineering


Abhishek Sharma, PhD (Editor) – Assistant Professor and Principal Investigator, C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Gujarat, India
Dhruti Amin, PhD (Editor) – Assistant Professor, C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Gujarat, India

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI049000; SCI010000

The last two decades of scientific research have progressed to the point where metabolic engineering, which involves the modifying of metabolic pathways of animals, plants, and bacterial cells at biochemical and molecular levels, is feasible. Conceptually, metabolic engineering takes into account the identification of major blocks or control points in a metabolic pathway at the molecular level followed by removal of these limitations with the help of various cellular engineering interventions. Understanding the metabolic pathways requires appropriate experiment setup, molecular biology and biochemistry methods, computational modelling, data analysis, and interpretation to allow the researchers to manipulate them as per their needs.

This book comprises a total of 12 chapters from multiple contributors of different countries around the world, including Brazil, Egypt, India, Saudi Arabia, and Turkey. This book provides deep insight into the past, present, and future of metabolic engineering in the animal, microbial, and plant system, communicating interdisciplinary research and relevant results in biochemistry, molecular biology, applied microbiology, cellular physiology, cellular nutrition in health and disease, and biochemical engineering.

Table of Contents



Chapter 1. Advances in Metabolic Engineering: Applications of CRISPR and Beyond
(Enuh Blaise Manga, Pınar Aytar Çelik, Belma Nural Yaman, Ahmet Çabuk – Department of Biotechnology and Biosafety, Graduate School of Natural and Applied Sciences, Eskişehir Osmangazi University, Eskişehir, Turkey, et al.)

Chapter 2. Significant Role of Metabolic Engineering in the Understanding of Cancer
(Aarti Gayakwad; Neha Shukla, Giftson J Senapathy – C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Bardoli, Gujarat, India)

Chapter 3. Genome Editing in Metabolically Engineered Breast Cancer Cells with a Special Focus on Nano-Therapeutic Applications
(P. Parizad, R. Krishnamurthy, Giftson J Senapathy – C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Bardoli, Gujarat, India)

Chapter 4. Invertebrate and Vertebrate Cell Cultures in Bio-Therapeutics
(Krutika Saurabh Abhyankar – Division of Biomedical and Life Sciences, School of Science, Navrachana University, Vadodara, India)

Chapter 5. An Insight in the Trends Timeline of Metabolic Engineering in Microbes and its Reflection on Future Scope
(Ketankumar J. Panchal – Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Anand, Gujarat, India)

Chapter 6. Metabolic Engineering Approach for Optimization of Microalgae Biorefinery using Phaeodactylum tricornutum as a Model Organism
(Chmitz Caroline, Bauer Claudia M., Maraschin Marcelo – Plant Morphogenesis and Biochemistry Laboratory, Federal University of Santa Catarina, Florianópolis, Brazil)

Chapter 7. Deciphering the Metabolic Adjustments of Engineered Plants using GC-MS: A Typical Workflow
(Maneesh Lingwan, Shyam Kumar Masakapalli – BioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India)

Chapter 8. Plants as a Bioreactor for Edible Vaccines: Emerging Excellence
(Ashraf Y.Z. Khalifa, T. Savitha, and A. Sankaranarayanan – Department of Biological Sciences, College of Sciences, King Faisal University, Al-Ahsa, Saudi Arabia, et al.)

Chapter 9. Recent Developments and Future Prospects of Plant-Based Vaccines
(Bairagi Ghanshamdas R., Vipul P. Patel – Sanjivani College of Pharmaceutical Education and Research, Kopargaon, India)

Chapter 10. Metabolic Engineering Approaches for Plant Secondary Metabolites Biosynthesis
(Subir Kumar Bose, Ramesh Kumar, Reshma Kapoor – Assistant Professor, Biotechnology and Microbiology Department (CCS Programme), Meerut Institute of Engineering and Technology (MIET), Meerut, Uttar Pradesh, India, et al.)

Chapter 11. Plant Metabolic Engineering: Promotion of Human Health
(Rita Mahapatra – Neotech Institute of Applied Science and Research, Virod, Vadodara, Gujarat, India)

Chapter 12. In Silico Studies Describing miRNAs and Their Regularity Processes in Industrial Important Medicinal and Aromatic Plants
(Anand Mishra, Pankhuri Gupta – Genetics and Plant Breeding Division, CSIR- Central Institute for Medicinal and Aromatic Plants, Lucknow, UP, India, et al.)


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