The Functional and Translational Immunology of Regulatory T Cells (Tregs), the Anti-Tumor T Cell Response, and Cancer

Michael A. Alexander
Widener University, One University Place, Chester, PA, USA

Series: Immunology and Immune System Disorders
BISAC: MED062000

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$185.00

Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Regulatory T cells (Tregs) are a vital component of the T cell immune system by their ability to control T cell responses that would lead to autoimmune disease. Tregs also protect damaged normal cells that are healing from T cells programmed to kill any abnormal cells in the body. Cancer (tumor) develops from normal cells and can express normal self-antigens. Tregs protect precancerous cells as if they were healing damaged cells and inhibit the anti-tumor T cell response by the use of advanced effector mechanisms, which stop the T cell immune system from effectively removing the tumor.

The function of cells involved in this process is controlled by the cell membrane activation of intracellular translational pathways interacting with the nucleus that produces transcriptional proteins, which control cellular behavior such as secretion of lymphokines or cell proliferation. This book examines the function and related translational pathways of Tregs, anti-tumor T cells, and cancer cells. It relates that information to the treatment of cancer by examining human clinical trials of new immune cell-based treatments (immunotherapy). The book also proposes ways to improve those treatments by manipulating the translational pathways of immunotherapeutic cells. The hope is that these new treatment proposals stimulate positive thought about the future of cancer immunotherapy (Imprint: Nova Biomedical )

Foreword

Acknowledgments

Introduction

Chapter 1 - The Immunobiology and Translational Immunology of Regulatory T Cells (pp. 1-26)

Chapter 2 - Autoimmunity, Tregs, and the Anti-Tumor T Cell Immune System (pp. 27-66)

Chapter 3 - Treg Effector Mechanisms (pp. 67-128)

Chapter 4 - Treg Immunobiology as It Relates to the Anti-Tumor T Cell Response during Immune Cell-Based Cancer Treatment (pp. 129-174)

Chapter 5 - The Functional and Translational Immunology of Regulatory T Cells (Tregs), the Anti-Tumor T Cell Response, and Cancer: Chapter Review (pp. 175-192)

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