The Essential Guide to Magnetic Resonance

Dorota Bartusik-Aebisher (Editor)
Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

Series: Biomedical Devices and their Applications
BISAC: MED019000

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The opening chapter of The Essential Guide to Magnetic Resonance presents applications of Fluorine-19 Magnetic Resonance Imaging (19F MRI) in cancer research, tissue metabolomics, quantification of drug delivery, cellular tracking, tissue pH measurements and detection of 19F labeled cells. The authors review in vitro research applying 19F MRI and Magnetic Resonance Spectroscopy (MRS) to facilitate the synthesis, tracking and visualization of new fluorinated drug conjugates. 19F MRI also provides high contrast in vivo images due to the absence of an endogenous 19F signal, 100% natural abundance of 19F, and a chemical shift range of over 400 ppm. Afterwards, examples of current methods of magnetic resonance imaging (MRI) guided photodynamic therapy are presented. Recent development of MRI detectable nanoparticle constructs, magnetic resonance spectroscopy (MRS) sensors, gadolinium based photosensitizers and europium singlet oxygen probes are discussed. In addition, applications of Functional MRI using a blood oxygen dependent level (BOLD) MRI in monitoring photodynamic action are addressed, with the goal of informing researchers about the potential for using MRI guided photodynamic therapy and oxygen dosimetry. The applications of MRI within the sphere of pharmacy are analyzed; in particular, the use of MRI to track pharmaceuticals in vitro and in vivo noninvasively and monitoring their controlled-release. Functional MRI for noninvasive clinical brain imaging is explored as it is applied to studies of autism, schizophrenia, epilepsy Alzheimer’s disease, Parkinson’s disease, traumatic brain injury and blood oxygenation-level dependent (BOLD) imaging of brain function. An overview of the scope of MRI as a diagnostic technique in neurology and in neurosurgery is also provided.

Preface

Chapter 1. 19F Magnetic Resonance Imaging and Spectroscopy in Vitro Applications
(Zuzanna Bober, David Aebisher, Jacek Tabarkiewicz, and Dorota Bartusik-Aebisher, Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland, and others)

Chapter 2. Magnetic Resonance Imaging Guided Photodynamic Therapy
(£ukasz O¿óg, Dorota Bartusik-Aebisher, Jacek Tabarkiewicz, and David Aebisher, Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland, and others)

Chapter 3. Application of MRI to the Study of Pharmaceuticals
(Zuzanna Bober, David Aebisher, Piotr Tutka, and Dorota Bartusik-Aebisher, Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland, and others)

Chapter 4 Functional MRI: How Does it Work?
(Adrian Truszkiewicz, David Aebisher, Jacek Tabarkiewicz, and Dorota Bartusik-Aebisher, Department of Electroradiology, Faculty of Medicine, University of Rzeszów, Poland, and others)

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