Table of Contents

Preface

Chapter 1. Epidemiology of Asthma
Tomás Chivato Pérez¹, MD, PhD, Francisco J. Caballero Segura², MD, Natalia Gutierrez Albadalejo³, MD  and Rodrigo Jiménez García⁴, MD, PhD
¹School of Medicine CEU San Pablo (Alcorcón, Spain)
²Respiratory Care Department. Hoospital General Universitario Gregorio Marañón (Madrid, Spain)
³Allergy Department. Hospital Universitario Fundación Alcorcón (Alcorcón, Spain)
⁴School of Medicine. Universidad Complutense de Madrid (Madrid, Spain)

Chapter 2. Immunology of Allergic Asthma and T2 Inflammation in Allergic Asthma
Paula Galvan-Blasco^1,2, MD,  Victoria Cardona Dahl^1,2,3,4, MD, PhD,  and Moisés Labrador-Horrillo^1,2,3,4, MD, PhD
¹Allergy Section, Internal Medicine Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain
²Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
³Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
⁴ARADyAL Research Network, Instituto de Salud Carlos III (ISCIII), Madrid, Spain

Chapter 3. Pollens Causing Asthma
Jesús Miguel García-Menaya^1,2,3, MD, PhD and Concepción Cordobés-Durán^2,4, MD
¹Allergy Service, Badajoz University Hospital, Spain
²ARADyAL Instituto de Salud Carlos III, Madrid, Spain
³Biomedical Sciences Department. University of Extremadura. Badajoz, Spain
⁴Allergy Service, Mérida Hospital. Mérida, Spain

Chapter 4. Mites and Fungal Spores Causing Asthma
Teresa Carrillo Diaz^1,2, MD, PhD,  and María del Pilar Cuesta Apausa¹, MD
¹Allergy Service, University Hospital of Gran Canaria Dr Negrín, Las Palmas, Spain
²University of Las Palmas de Gran Canaria, Las Palmas, Spain

Chapter 5. Diagnosis of Asthma: Clinical Symptoms and Tests
Alejandra Carrón Herrero, MD, María Daniela de Jesús Escalante Carrero, FIT,  Patricia Gutiérrez Canales, FIT,  and Darío Antolín-Amérigo, MD, PhD
Allergy Department. Hospital Universitario Ramón y Cajal, Madrid, Spain

Chapter 6. Occupational Allergic Asthma
Santiago Quirce, MD, PhD
Department of Allergy, La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain

Chapter 7. Severe Asthma
Carmen Panaitescu^1,2, MD, PhD, Roxana Silvia Bumbacea^3,4, MD, PhD, Rama Boustani⁴, MD, Maria-Roxana Buzan^1,2, MD, PhD, Laura Haidar¹, MD, PhD, Catalina Cojanu⁵, MD, Alexandru Laculiceanu⁵, MD, Daniela Spinu⁵, PhD, and Ioana Agache⁵, MD, PhD
¹Department of Functional Sciences, Physiology, Centre of Immuno-Physiology and Biotechnologies (CIFBIOTECH), “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania
²Centre for Gene and Cellular Therapies in The Treatment of Cancer – OncoGen, “Pius Brinzeu,”  Clinical Emergency Hospital, Timisoara, Romania
³Allergy Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
⁴Allergy Department, Nephrology Hospital Dr. Carol Davila, Bucharest, Romania
⁵Faculty of Medicine, Transylvania University, Brasov, Romania

Chapter 8. An Update on Thunderstorm Allergy and Asthma
Gennaro D’Amato^1,2, MD, Isabella Annesi-Maesano³, MD, Lorenzo Cecchi⁴, MD, Benedetta Biagioni⁵, MD, and María D’Amato^2,6, MD
¹Division of Respiratory and Allergic Diseases, Department of Chest Diseases, High Speciality A. Cardarelli Hospital, Naples, Italy
²Medical School of Specialization in Respiratory Diseases, University of Naples Federico II, Naples, Italy
³Institut Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Department of Allergic and Respiratory Diseases, Montpellier University Hospital, Montpellier, France
⁴Centre of Bioclimatology, University of Florence, Florence, Italy
⁵Allergy Outpatient Clinic, Division of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria Bologna, Bologna, Italy
⁶First Division of Pneumology, High Speciality Hospital ‘V. Monaldi’ and University ‘Federico II’ Medical School Naples, Naples, Italy

Chapter 9. Asthma and Climatic Change
Javier Subiza¹, MD, and Martha Cabrera², MD, PhD
¹Subiza Clinic, Madrid, Spain
²Allergy Department, Hospital Los Madroños, Brunete, Madrid, Spain

Chapter 10. Air Pollution and Asthma
Francisco Feo Brito^1,7, MD, PhD, Pilar Mur Gimeno², MD, PhD, Javier Fernández Sánchez³, MD, PhD, José Antonio Lucas García⁴, PhD, Teresa Alfaya Arias⁵, MD, PhD and José Miguel Urra Ardanaz PhD^6,7
1Allergy Section, Ciudad Real General University Hospital, ARADyAL, Spain
²Allergy Unit, Hospital Santa Barbara, Puertollano, Spain
³Allergy Section, Alicante General University Hospital, Dr. Balmis, and Clinical Medicine Department, Miguel Hernández University, ISABIAL-UMH, Spain
⁴Pharmaceutical and Health Sciences Department, Faculty of Pharmacy, Universidad San Pablo-CEU, Madrid, Spain
⁵Allergy Unit, Hospital Universitario Fundación Alcorcón, Madrid, Sapin
⁶Immunology, Ciudad Real General University Hospital, ARADyAL, Spain
⁷Ciudad Real Medical School, University of Castilla-La Mancha, Ciudad Real, Spain

Chapter 11. Allergic Asthma and Viruses
Alicia Armentia-Medina^1,2, MD, PhD, Cristina Díaz-Rodríguez³, MD and David Pérez-Torres³, MD
¹Servicio de Alergia, Hospital Universitario Río Hortega, Spain
²Universidad de Valladolid. Facultad de Medicina. Call Ramón y Cajal, Valladolid, Spain
³Servicio de Medicina Intensiva, Hospital Universitario Río Hortega, Spain

Chapter 12. United Airway Disease
Ricardo Madrigal-Burgaleta¹, LMS, MD, PhD, F. Runa Ali¹, BSc, MBBS, PhD, FRCP, Bryan N. Fernandes¹, MBBS, MRCP, Matt Lechner², MD, PhD, FRCS,  Nara Orban², PhD, MEd(Surg), DIC, DLO, FRCS(ORL-HNS) and Paul Pfeffer¹, MBBS, PhD, MRCP
¹Allergy & Severe Asthma Service, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
²Ear, Nose and Throat (ENT) Service, Royal London Hospital, Barts Health NHS Trust, London, UK

Chapter 13. Allergic Bronchopulmonary Aspergillosis
Álvaro Moreno-Ancillo^1,2,5, MD, Marta Jiménez Arroyo^1,3, MD, Miriam Artero Clemente³, MD, Jesús Jurado Palomo², MD, PhD, José Manuel Bravo Nieto^1,3, MD,
and Ana Carmen Gil-Adrados^4,5, MD
¹Severe Asthma Multidisciplinary Unit, Hospital Nuestra Señora del Prado,
Área Integrada de Salud de Talavera de la Reina, Spain
²Allergology Service, Hospital Nuestra Señora del Prado, Área Integrada de Salud de Talavera de la Reina, Spain
³Pneumology Service, Hospital Nuestra Señora del Prado, Área Integrada de Salud de Talavera de la Reina, Spain
⁴Primary Care, Centro de Salud Río Tajo, Área Integrada de Salud de Talavera de la Reina, Spain
⁵Asociación para la Investigación en Alergia y Asma, Spain

Chapter 14. Aspirin-Exacerbated Respiratory Disease
Inmaculada Doña^1,2, MD, PhD, Ibon Eguiluz^1,2, MD, PhD and María José Torres^1,2,3,4, MD, PhD
¹Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain
²Allergy Unit, Hospital Regional Universitario de Málaga, Málaga, Spain
³Nanostructures for Diagnosing and Treatment of Allergic Diseases Laboratory,  Andalusian Center for Nanomedicine and Biotechnology-BIONAND, Málaga, Spain
⁴Departamento de Medicina, Universidad de Málaga, Málaga, Spain
Chapter 15 Pharmacological Treatment of Asthma
Manuel J. Rial Prado¹, MD, PhD, Carolina Gómez Fariñas¹, MD and Raquel Eiras Leal², MD
¹.Allergy Department. Severe Asthma Unit. Complexo Hospitalario Universitario A Coruña. Galicia. Spain
^2. Instituto de Investigación Sanitaria A Coruña (INIBIC). Complexo Hospitalario Universitario A Coruña, Galicia, Spain

Chapter 16. Immunotherapy for Asthma
Carmen Vidal^1,2, MD, PhD, and Paula Méndez-Brea¹, MD
¹Department of Allergy, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
²Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain

Chapter 17. Biological Treatments for Asthma
Cristina Martín-García^1,2 , MD, PhD, Alicia Gallardo-Higueras¹, MD, and Ignacio Dávila^1,2,3,4, MD, PhD
¹Allergy Service, Hospital Universitario de Salamanca, Salamanca, Spain
²Instituto Biosanitario de Salamanca, Salamanca, Spain
³Department of Biomedical and Diagnostic Sciences, University of Salamanca, Salamanca, Spain
⁴RETIC ARADyAL, Instituto de Salud Carlos III, Spain

Chapter 18. Clinical Pharmacogenomics in Asthma Therapy
Pedro Ayuso^1,2, PhD, Jesús Miguel García-Menaya^2,3,4, MD, PhD, Concepción Cordobés-Durán^2,5, MD,
José A. G. Agúndez^1,2, MD, PhD,
and Elena García-Martín^1,2, MD, PhD
¹Universidad de Extremadura, University Institute of Molecular Pathology Biomarkers, Cáceres, Spain
²ARADyAL Instituto de Salud Carlos III, Madrid, Spain
³ Biomedical Sciences Department. Universidad de Extremadura
⁴Allergy Service, Badajoz University Hospital, Badajoz, Spain
⁵Allergy Service, Mérida Hospital, Mérida, Spain

Index

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Editor’s ORCID iD

Jesús Miguel García-Menaya – 0000-0002-3931-2568