The CRISPR/Cas9 System: Applications and Technology

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Alfred A. Bertelsen (Editor)

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI029000

This compilation focuses on the CRISPR/Cas9 system, a genome editing tool that has been hailed as the most profound molecular biology discovery in the past decade. By employing the natural process of bacterial immunity towards bacteriophages, the tool allows researchers to precisely excise and edit parts of the genetic sequence to modify them.

The authors summarize the molecular pathogenesis of hepatocellular carcinoma, available treatments/drugs and their limitations, the landscape of CRISPR targeting hepatocellular carcinoma, limitations and potential targets in future.

The closing review summarises the use of CRISPR/Cas9 gene editing in ophthalmology and focuses on the advancement of gene editing in the cornea. The majority of corneal dystrophies are the result an autosomal dominant inheritance pattern within the TGFBI gene, which presents an ideal model suited for a CRISPR/Cas9 knock out methodology.
(Imprint: Nova)

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Table of Contents

Preface

Chapter 1. CRISPR/Cas9: The Emergence and Applications of a Revolutionary Gene-Editing Tool
(Andrew Octavian Sasmita, Hossein Jahedi, Stephanie Loo and Anna Ling Pick Kiong, Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Georg-August-Universität Göttingen, Göttingen, Germany

Chapter 2. Current Progress in HCC using CRISPR: The latest Gene Editing Tool
(Bushra Ijaz, Usman Ali Ashfaq, Arooj Anwaar, Zeeshan, Hamza Anjum, Tayyab Husnain, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan, and others)

Chapter 3. The Application of CRISPR/Cas9 Therapies in Ophthalmology and Recent Advances for the Treatment of Genetic Eye Disease
(Tara Moore, Larry DeDionisio, Hila Roshanravan, Connie Chao-Shern and M. Andrew Nesbit, Ulster University, Coleraine, County Londonderry, Northern Ireland, and others)
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