The Conundrum of Toxic Epidermal Necrolysis


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Series: Emergency and Intensive Care Medicine
BISAC: MED017000

Adverse drug reactions commonly affect the skin. In rare instances, they cause severe morbidity and possibly lead to drug-induced mortality. Toxic epidermal necrolysis (TEN) represents the archetype of such conditions.

This book summarizes the recent advances in the field of TEN as a major life-threatening adverse drug reaction. Indeed, this dramatic condition remains a puzzling topic for both the clinician at the bedside and in the laboratory. This book is fully updated about the putative biomechanisms, the clinico-pathological correlations and recent treatment advances.

The most damaging effects of TEN reside in the skin, eyes and oral mucosa. Physicians keen in intensive care medicine, dermatology and ophthalmology should find here stimulating concepts applicable to the patient with the hope of reducing the TEN fatalities. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents



Acronyms and Abbreviations

Part I: General Considerations

Chapter 1 – From Lyell’s Syndrome to Toxic Epidermal Necrolysis (pp. 3-4)

Chapter 2 – The Keratinocyte, Major Target and Actor (pp. 5-10)

Chapter 3 – Immunological Mechanisms (pp. 11-12)

Part II: Clinico-Pathologic Features

Chapter 4 – Cutaneous and Mucosal Clinical Presentations (pp. 15-18)

Chapter 5 – Extracutaneous Involvement (pp. 19-28)

Chapter 6 – Histopathology (pp. 29-32)

Chapter 7 – Proteomic Kinetic Analysis (pp. 33-34)

Chapter 8 – Differential Diagnosis (pp. 35-44)

Chapter 9 – Drug Impact (pp. 45-46)

Chapter 10 – Pharmacogenetics (pp. 47-48)

Chapter 11 – Lymphocytic Impact (pp. 49-52)

Chapter 12 – Monocyte-Macrophage and Mesenchymal Cell Impact (pp. 53-54)

Chapter 13 – Keratinocyte Pathobiology and Demise (pp. 55-70)

Chapter 14 – Analytic Skin Biometrology (pp. 71-74)

Part III: Management

Chapter 15 – TEN Prevention (pp. 77-78)

Chapter 16 – Prognosticators (pp. 79-84)

Chapter 17 – Supportive Care Management (pp. 85-88)

Chapter 18 – Survival Management (pp. 89-90)

Chapter 19 – Topical Treatment (pp. 91-98)

Chapter 20 – Systemic Pharmacotherapy (pp. 99-106)

Chapter 21 – Tissue Replacement (pp. 107-108)

Chapter 22 – Cost-Effectiveness of Treatment (pp. 109-110)

Part IV: Framing the Future

Chapter 23 – Spotlight on Perspective (pp. 113-116)



Additional Information

Audience: Medical students, dermatologists, intensive care physicians, burn units, ophthalmologists.

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