The Central Catecholaminergic System: Anatomy, Functions and Disorders

Bertalan Dudas, MD, PhD (Editor)
Lake Erie College of Osteopathic Medicine (LECOM), Erie, PA, USA

Series: Neuroscience Research Progress
BISAC: SCI089000

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The catecholaminergic system is one of the most studied neurotransmitter systems in the central nervous system. Since the original studies of Dahlström and Fuxe in the mid-60s, when they mapped the pattern of monoaminergic neurons using formaldehyde-induced flourescence technique developed by Falck and Hillarp, the distribution and the biological roles of catecholamines have been in the center of interest. It is clear now that catecholaminergic transmission not only plays a pivotal role in the modulation of stress response, but is also involved in numerous cortical functions, such as cognition, memory, learning, mood and behavior.

Additionally, the catecholaminergic system appears to control vital hypothalamic functions. Several physiological processes, including growth, sexual regulation, and salt and water balance are regulated by catecholamines, either directly or via complex circuitries involving numerous neurotransmitter/neuroregulator systems. Both the involvement of catecholamines in Alzheimer’s and Parkinson’s diseases and their pivotal roles in schizophrenia and manic depression place these neurotransmitters in the focus of drug development that aims to address neurodegenerative disorders and psychiatric conditions. The present book attempts to give the reader a synopsis of the physiology and pathology of these important catecholaminergic functions. (Imprint: Nova Biomedical )

Preface

List of Contributors

Chapter 1 - Anatomy of the Central Catecholaminergic System (pp. 1-24)
Bertalan Dudás and Martha C. Bohn (Lake Erie College of Osteopathic Medicine, USA and others)

Chapter 2 - Biochemistry of Catecholamines (pp. 25-40)
Thomas D. Corso and Bertalan Dudás (Lake Erie College of Osteopathic Medicine, USA)

Chapter 3 - Catecholaminergic Regulation of the Hypothalamic Neuropeptide Y (NPY) and Galanin Systems (pp. 41-61)
Bertalan Dudás and István Merchenthaler (Lake Erie College of Osteopathic Medicine, USA and others)

Chapter 4 - Stress and Gonadal Functions: The Role of Catecholamines (pp. 62-83)
Bertalan Dudás and István Merchenthaler (Lake Erie College of Osteopathic Medicine, USA and others)

Chapter 5 - Central Catecholaminergic Regulation of Growth (pp. 84-99)
Bertalan Dudás and István Merchenthaler (Lake Erie College of Osteopathic Medicine, USA and others)

Chapter 6 - Catecholaminergic Regulation of the Magnocellular Neurosecretory System (pp. 100-117)
Bertalan Dudás and István Merchenthaler (Lake Erie College of Osteopathic Medicine, USA and others)

Chapter 7 - Toxic Metabolites of Catecholamines in Parkinson’s Disease (pp. 118-141)
Thomas D. Corso and George Grignol (Lake Erie College of Osteopathic Medicine, USA)

Chapter 8 - The Role of Fibroblast Growth Factor (FGF) Signaling on Dopaminergic Function in Parkinson’s Disease (pp. 142-155)
Aaron Kucinski, Ryan Curl, Robert S. Miletich, Thomas D. Corso, Ewa K. Stachowiak and Michal K. Stachowiak (Department of Psychology, University of Michigan, Ann Arbor, MI, USA, and others)

Chapter 9 - Schizophrenia and the Dopaminergic System (pp. 156-177)
Robert S. Miletich, Aaron Kucinski, Sridhar Narla, Courtney Benson, Scott Wersinger, Thomas D. Corso, Merouane Bencherif, Ewa K. Stachowiak and Michal K. Stachowiak (Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, NY, USA and others)

Chapter 10 - Catecholamines and Bipolar Disorder (pp. 178-205)
Moritz Mühlbacher and Irene Lehner-Adam (University Hospital for Psychiatry and Psychotherapy, Paracelsus Medical University, and Christian Doppler University Clinic Salzburg, Salzburg, Austria)

Chapter 11 - Catecholamines and Alzheimer’s Disease (pp. 206-239)
Michael S. Peroski and Bertalan Dudás (Lake Erie College of Osteopathic Medicine, USA and others)

Chapter 12 - Catecholamines and Tourette Syndrome: Frontal-Subcortical Circuits and Their Neurochemical Modulation (pp. 240-256
David G. Lichter (State University of New York at Buffalo, Buffalo, NY, USA)

Index

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