The Blood-Brain Barrier Roadblock: Strategies for Targeted Drug Delivery


Authors: Geoffrey H. Morris, Tessa N. Campbell, and Francis Y. M. Choy
Page Range: 63-70
Published in: Journal of Biochemistry and Molecular Biology in the Post Genomic Era, 2#2 (2012)
ISSN: 2156-5732

Table of Contents


Despite ongoing medical advances, the development of successful treatments for neurological and neurodegenerative disease remains challenging. This is primarily due to the presence of the blood-brain barrier, a protective interface that reduces exposure of the brain to potential toxins. Unfortunately, this barrier acts as a roadblock for drug delivery, preventing transport of neurotherapeutics across the membrane to their targets within the brain. Numerous approaches have been undertaken to overcome the blood-brain barrier obstacle. Such strategies include: direct injection into the brain, therapeutic ultrasound, cell-penetrating peptides, and nanoparticles. In this review, we discuss the theory behind these approaches, as well as the advantages and limitations of each method.

Keywords: Blood-brain barrier, drug delivery, ultrasound, cell penetrating peptides, protein transduction domain, nanoparticles

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