The Art of Neuroendocrinology: A Case-Based Approach to Medical Decision-Making

Lewis S. Blevins, Jr. (Editor)
Professor of Neurological Surgery and Medicine, University of California, San Francisco, CA, USA

Series: Endocrinology Research and Clinical Developments, Neurology – Laboratory and Clinical Research Developments
BISAC: MED056000

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The Art of Neuroendocrinology: A Case-based Approach to Medical Decision-Making is not your standard textbook of pituitary endocrinology. This comprehensive collection of works presents unique, interesting, and often challenging patient cases. These reports illustrate the complexities of medical decision-making, incorporating evidence-based medicine and the practice of the art of medicine, in the evaluation and management of patients with various pituitary disorders. Experts in the field present their illustrative case studies, a related state-of-the-art review of the literature on one or more relevant topics, discuss the diagnostic and/or therapeutic dilemmas, share their thought processes to reflect their medical decision-making, and review the outcomes of the decisions in their patients.

The purpose of this textbook is to bring together the art of the practice of neuroendocrinology, evidence-based medicine, pertinent clinical guidelines, and everyday problem-solving skills that we employ in the surgical/non-surgical evaluation and management of patients. While oriented towards healthcare professionals, this text will also be useful to patients and their families. (Imprint: Nova Biomedical)

Preface

Chapter 1. Hyperprolactinemia and Cushing’s Disease: Occam’s Razor vs Hickam's Dictum
Julio Abucham and Silvia R. Correa-Silva (Neuroendocrine Unit, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil)

Chapter 2. Langerhans Cell Histiocytosis: Pathophysiology, Diagnosis, and Management
Pedro Marques, Conceição Pereira and Márta Korbonits (Department of Endocrinology, Instituto Português de Oncologia de Lisboa, Portugal, and others)

Chapter 3. A Patient Presenting with Headache and Epistaxis
Nicholas A. Tritos (Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA, and others)

Chapter 4. A Rare Presentation of TSH Secreting Pituitary Macroadenoma with Coexisting Primary Hypothyroidism from Hashimoto’s Thyroiditis
Afreen Idris Shariff, Lauren Gratian and Jennifer Perkins (Division of Endocrinology, Diabetes and Metabolism, Duke University School of Medicine, Durham, NC, USA)

Chapter 5. Management of Osteoporosis in a Man with Cushing’s Disease and Hypogonadotrophic Hypogonadism following Successful Transsphenoidal Surgery
Farhad M. Hasan, Jason Sheehan and Gregory Hong (Division of Endocrinology, Department of Internal Medicine, Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA)

Chapter 6. Multidisciplinary Management of Atypical Pituitary Adenomas
David J. Cote, Hasan A. Zaidi, Ian F. Dunn, and Edward R. Laws, Jr (Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA)

Chapter 7. A Referral for Delayed Puberty May Unveil an Underlying Complex Syndrome
Luigi Maione and Annamaria Colao (Service d'Endocrinologie et Maladies de la Reproduction, Service d'Hormonologie, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, and Universite Paris-Sud, Le Kremlin-Bicetre, France, and others)

Chapter 8. Management of Cystic Prolactinomas
Alexander Faje and Brooke Swearingen (Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA, and others)

Chapter 9. Primary Generalized Glucocorticoid Resistance Syndrome
Zahrae Sandouk and Betul Hatipoglu (Cleveland Clinic, Department of Endocrinology, Diabetes & Metabolism, Cleveland, OH, USA)

Chapter 10. Management of Persistent Disease after Surgery in a Young Woman with Acromegaly
Dawn Shao Ting Lim and Maria Fleseriu (Northwest Pituitary Center, and Departments of Neurosurgical Surgery and Medicine, Oregon Health & Science University, Portland, OR, USA)

Chapter 11. Cushing’s Syndrome: What Should We Do While Investigating for the Source?
Jeffrey Wagner and Maria Fleseriu (Northwest Pituitary Center, and Departments of Neurosurgical Surgery and Medicine, Oregon Health & Science University, Portland, OR, USA)

Chapter 12. Challenges in the Management of Ectopic Cushing’s Syndrome
Iqra Javeed, Namrata Chandhok, Ronald M. Lechan, Arthur S. Tischler, Richard Siegel, and Jacqueline Kung (Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, MA, USA, and others)

Chapter 13. A Case of Gigantism
Harminder Singh, Sarang Rote, Walid I. Essayed, and Theodore H. Schwartz (Stanford University School of Medicine, Stanford, CA, USA, and others)

Chapter 14. Pituitary Stalk Lesions: Challenges in Diagnosis
Dina Winograd and Susan L. Samson (Associate Professor of Medicine, Baylor College of Medicine, Medical Director, The Pituitary Center, Baylor St. Luke’s Medical Center, Houston, TX, USA, and others)

Chapter 15. When Cushing’s Comes and Goes…
Victoria Stokes and Ashley Grossman (Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK)

Chapter 16. Hyponatremia after Pituitary Surgery: SIADH or Cerebral Salt Wasting?
Erin Downs and Joseph Verbalis (Medstar Georgetown University Hospital/Medstar Washington Hospital Center, Division of Endocrinology and Metabolism, Washington, DC, USA)

Chapter 17. Cushing’s Disease Identified Post-Adrenalectomy for Adrenal Nodules
Shervin Yousefian and Robert J. Anderson (Division of Endocrinology, Creighton University Medical Center, Omaha, NE, USA)

Chapter 18. Cushing’s Syndrome: You Have to Dot the “I’s” and Cross the “T’s”
Mark E. Molitch (Martha Leland Sherwin Professor of Endocrinology, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA)

Chapter 19. Headaches in a Patient with a Pituitary Mass
Ana Espinosa De Ycaza and Dana Erickson (Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA)

Chapter 20. Cushing's Syndrome in Men-1: A Rare Association and a Challenging Diagnosis
Rosa Maria Paragliola and Roberto Salvatori (Unit of Endocrinology, Università Cattolica del Sacro Cuore, Rome, Italy, and others)

Chapter 21. A Medically Complicated Case of Acromegaly with Challenging Decision Making
Ankush Chandra and Manish K. Aghi (University of California, San Francisco (UCSF) Department of Neurological Surgery, CA, USA)

Chapter 22. Effects of Testosterone Replacement on Prolactinoma Management
Odelia Cooper (Assistant Professor of Medicine, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Chapter 23. Management of an Aggressive Silent Corticotroph Adenoma
Odelia Cooper (Assistant Professor of Medicine, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Chapter 24. Pregnancy in Women with Hypopituitarism and Growth Hormone Substitution Therapy
Pedro Gil, Lilian Mendoza-Mathison and Susan M. Webb (Endocrinology/Medicine Department, Hospital Sant Pau, Spain, and others)

Chapter 25. Treatment of Aggressive Prolactin-Secreting Pituitary Adenomas with Adjuvant Temozolomide Chemotherapy
Marc Moisi, Aurora Cruz, Marc R. Mayberg, Tara L. Benkers, Steven Rostad, Frances Broyles, and Kevin C.J. Yuen (Swedish Neuroscience Institute, Seattle, WA, USA)

Chapter 26. A Suprasellar Mass of Unclear Etiology Presenting at a Time of Concurrent Metastatic Carcinoma Diagnosis
Lindsey Ross, Serguei Bannykh and Adam N. Mamelak (Departments of Neurosurgery and Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Chapter 27. Management of Acromegaly in a Patient with McCune Albright Syndrome
Safwaan Adam and Peter J. Trainer (The Christie Hospital NHS Foundation Trust, Manchester, UK, and others)

Chapter 28. Nondiagnostic Inferior Petrosal Sinus Sampling in Suspected Cushing Disease
Pamela S. Jones and Brooke Swearingen, Department of Neurosurgery (Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA)

Chapter 29. Recurrent Hyponatremia with Normal Cosyntropin Stimulation: Don’t Ignore Secondary Adrenal Insufficiency
Shivangi Vachhani, Shiksha Sharma, Laura Cowen, Diane Krieger, and Joseph G. Verbalis (Division of Endocrinology and Metabolism, Georgetown University Medical Center, WA, DC, USA)

Chapter 30. Pituitary Adenoma and Other Considerations
Garni Barkhoudarian and Daniel F. Kelly (Pacific Pituitary Disorders Program, John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, CA, USA)

Chapter 31. Diagnosis and Treatment of an ACTH-Secreting Ectopic Pituitary Adenoma in the Sphenoid Sinus
Justin Seltzer, John D. Carmichael, Gabriel Zada, and Martin Weiss (Department of Neurosurgery, Division of Endocrinology, Department of Medicine, USC Pituitary Center, Keck School of Medicine of USC, Los Angeles, CA, USA)

Chapter 32. Microsurgical Transsphenoidal Chiasmapexy for Empty Sella Syndrome and Traction Chiasmopathy
Monica Rodriguez, Macaulay Nwojo, Jane W. Chan, Andrew S. Little, and William L. White (Departments of Endocrinology and Neurosurgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA)

Chapter 33. Cystic Prolactinomas-Management Considerations
Kevin O. Lillehei, Steven Carr and Janice M. Kerr (University of Colorado Denver, Aurora, CO, USA)

Chapter 34. Striving for the Best Possible Quality of Life in a Complex Cushing's Patient: Cure or Control?
Daniel J. Lobatto, Amir H. Zamanipoor Najafabadi, Wouter R. van Furth, and Nienke R. Biermasz (Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands, and others)

Chapter 35. Adipsic Diabetes Insipidus: Challenges in Diagnosis and Management
Yuval Eisenberg and Lawrence A. Frohman (Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA)

Chapter 36. An Unusual Pituitary Adenoma
Moises Mercado (Experimental Endocrinology Unit, Hospital de Especialidades, Centro Médico Nacional S.XXI, IMSS and the ABC Neurological Center, Mexico City, Mexico)

Chapter 37. Is It Cushing's Disease?
Laurence Kennedy and Megan Crawford (Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH, USA)

Chapter 38. A Case of Hyperprolactinemia
Laurence Kennedy and Doksu Moon (Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH, USA)

Chapter 39. McCune-Albright Syndrome and Acromegaly
Sana S. Meah, Jacob F. Baranoski, Stephen W. Coons, Andrew S. Little, Laura A. Knecht, and William L. White (Banner University Medical Center/Phoenix VA Health Care System, Phoenix, AZ, USA, and others)

Chapter 40. Parasellar Inflammatory Pseudotumor
Sana S. Meah, Jacob F. Baranoski, Stephen W. Coons, Anna R. Boron, Andrew S. Little, and William L. White (Banner University Medical Center, Phoenix VA Health Care System, Phoenix, AZ, USA, and others)

Chapter 41. Striving for the Best Possible Quality of Life in a Complex Acromegaly Patient: What Are My Options?
Daniel J. Lobatto, Marco J.T. Verstegen, Amir H. Zamanipoor Najafabadi, Nienke R. Biermasz, and Wouter R. van Furth (Leiden University Medical Center, Leiden, The Netherlands)

Chapter 42. A Case of Concurrent Central Hypothyroidism and Graves’ Disease
Lee-Shing Chang, Sashank Prasad and Whitney W. Woodmansee (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA)

Chapter 43. Classification and Management of Atypical Pituitary Prolactinomas
Jesse M. Thon, Ian F. Dunn, Sashank Prasad, Lakshmi Nayak, and Whitney W. Woodmansee (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA)

Chapter 44. Atypical Pituitary Adenoma Converting to Pituitary Carcinoma: A Multimodal Approach
Zachary Barnard, J. Manuel Sarmiento, Adam N. Mamelak (Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Chapter 45. I Suspect my Patient Has a Thyrotropinoma: What’s Next?
A.G. Ioachimescu (Department of Medicine (Endocrinology) and Neurosurgery, Emory University, Druid Hills, GA, USA)

Chapter 46. Pituitary Abscess: An Uncommon Condition Requiring Multidisciplinary Care
S. Chandra-Reddy, P.R. Chapman, J. Dionne-Odom, K.O. Riley, and T.B. Vaughan, III (University of Alabama at Birmingham, AL, USA)

Chapter 47. Treatment Decisions in a Patient with Bilateral Adrenal Hyperplasia and Cushing's Syndrome
Gemma Cuixart, Alba Morilla and Susan M. Webb (Endocrinology/Medicine Department, Hospital de la Santa Creu i Sant Pau, Spain, and others)

Chapter 48. Management Considerations in a Giant Prolactinoma Recalcitrant to Dopamine Agonist Therapy
Martin J . Rutkowski, Philip Theodosopoulos and Lewis Blevins (California Center for Pituitary Disorders, Department of Neurological Surgery University of California, San Francisco, San Francisco, CA, USA)

Index

Audience: Professionals, patients, students. Professional groups include Endocrine Society and Neurologicl societies as well as AACE. Patient support groups would be interested…Pituitary World News, Pituitary Network Association, NORD, Acromegaly Network, etc.

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