The Apoptosis-Inducing Factor (AIF) Moves from Mitochondria to the Nucleus and Back to the Cytoplasm during Apoptosis
Maria Grazia Bottone, Vincenzo Giansanti, Paola Veneroni, G. Bernocchi, A. Ivana Scovassi and Carlo Pellicciari (Editors)
Università di Pavia, Pavia, Italy, and others
Series: Cell Biology Research Progress
BISAC: SCI017000
Details
During apoptosis, the Apoptosis Inducing Factor (AIF) is known to be released from the mitochondrial intermembrane space to the cytosol, and moves to the nucleus. This new book reviews the basic morphological and molecular features of apoptosis and the role played by AIF in the intrinsic apoptotic pathway. In particular, based on multicolor immunocytochemistry at conventional and confocal fluorescence microscopy, discussed herein is the dynamic relocation of AIF throughout the apoptotic process in mammalian cells driven to apoptosis by different agents (etoposide, actinomycin D, cisplatinum, carboxamide) or photosensitized with the fluorogenic substrate Rosa Bengal acetate. (Imprint: Nova Biomedical)
ABSTRACT
AN INTRODUCTION TO APOPTOSIS
MORPHOLOGICAL AND BIOCHEMICAL HALLMARKS OF APOPTOSIS
THE APOPTOTIC PROGRAM AND MITOCHONDRIA
AIF AND CELL DEATH
DYNAMIC RELOCATION OF AIF DURING APOPTOSIS
PERSPECTIVES
ACKNOWLEDGEMENTS
REFERENCES
INDEX
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