The Apoptosis-Inducing Factor (AIF) Moves from Mitochondria to the Nucleus and Back to the Cytoplasm during Apoptosis

Maria Grazia Bottone, Vincenzo Giansanti, Paola Veneroni, G. Bernocchi, A. Ivana Scovassi and Carlo Pellicciari (Editors)
Università di Pavia, Pavia, Italy, and others

Series: Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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During apoptosis, the Apoptosis Inducing Factor (AIF) is known to be released from the mitochondrial intermembrane space to the cytosol, and moves to the nucleus. This new book reviews the basic morphological and molecular features of apoptosis and the role played by AIF in the intrinsic apoptotic pathway. In particular, based on multicolor immunocytochemistry at conventional and confocal fluorescence microscopy, discussed herein is the dynamic relocation of AIF throughout the apoptotic process in mammalian cells driven to apoptosis by different agents (etoposide, actinomycin D, cisplatinum, carboxamide) or photosensitized with the fluorogenic substrate Rosa Bengal acetate. (Imprint: Nova Biomedical)

ABSTRACT

AN INTRODUCTION TO APOPTOSIS

MORPHOLOGICAL AND BIOCHEMICAL HALLMARKS OF APOPTOSIS

THE APOPTOTIC PROGRAM AND MITOCHONDRIA

AIF AND CELL DEATH

DYNAMIC RELOCATION OF AIF DURING APOPTOSIS

PERSPECTIVES

ACKNOWLEDGEMENTS

REFERENCES

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