Th17 Cells in Health and Disease

Tsvetelina Velikova, MD, PhD (Editor)
Clinical Immunology, University Hospital Lozenetz, Sofia, Bulgaria

Series: Immunology and Immune System Disorders
BISAC: MED044000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book focuses on the Th17 cells and their involvement in health processes and a wide specter of disorders related to Th17 cells. The book intends to provide the reader with a comprehensive overview of the current knowledge on the hot and controversial topics regarding Th17 cells.

Th17 cells have been investigated intensively in recent years. These cells play an essential role not only in protective immunity but also contribute to chronic inflammation in many immune-mediated disorders. The role of IL-17 and Th17 in different pathways has changed several paradigms in immunology, especially those related to chronic inflammation. The existing concepts of immunopathologic mechanisms related to Th17 cells in various pathological processes in the organism have been confirmed by many studies. Furthermore, the number of conditions influenced by Th17 cells seems to be increasing.

The book covers the role of Th17 cells in human health and pathological processes such as inflammation, autoimmunity, allergy, cancerogenesis, etc. The pathologies related to these lymphocytes are in the field of rheumatology (rheumatoid arthritis, spondyloarthropathies, systemic sclerosis), gastroenterology (inflammatory bowel disease, celiac disease, colorectal cancer, dermatology, allergy, neurology (multiple sclerosis), and respiratory medicine (allergic rhinitis, asthma, cystic fibrosis), in both children and adults. Special attention is paid to the controversial interaction between Th17 cells and T regulatory cells in autoimmunity and inflammation.
(Imprint: Nova Medicine and Health)

Dedication

Preface

Chapter 1. Th17 Cells in Health
(Tsvetelina Velikova, MD, PhD, Clinical Immunology, University Hospital Lozenetz, Sofia University, Sofia, Bulgaria)

Chapter 2. The Role of Th17 Cells in Osteoclastogenesis and Rheumatoid Arthritis
(Yuki Nanke, MD, PhD, and Shigeru Kotake, MD, PhD, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, and others)

Chapter 3. Phenotypic and Functional Heterogeneity of Th17 Cells in Systemic Sclerosis
(Rositsa V. Karalilova, MD, PhD, Department of Internal Diseases, Medical University of Plovdiv, University Hospital "Kaspela", Clinic of Rheumatology, Plovdiv, Bulgaria)

Chapter 4. The Role of Th17 Cells in Spondyloarthritis
(Yuki Nanke, MD, PhD, and Shigeru Kotake, MD, PhD, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan)

Chapter 5. Allergic Rhinitis, IL-17 and the Concept of a Common Respiratory Pathway
(Kremena Naydenova, MD, Tsvetelina Velikova, MD, PhD, and Vasil Dimitrov, MD, PhD, Clinical Center of Allergology, University Hospital Alexandrovska, Sofia, Bulgaria, and others)

Chapter 6. Th17 Cells in Childhood Asthma
(Snezhina Lazova, MD, PhD, Guergana Petrova, MD, PhD, and Tsvetelina Velikova, MD, PhD, Pediatric Department, University Hospital “N. I. Pirogov”, Sofia, Bulgaria, and others)

Chapter 7. Th17 Cells and Cystic Fibrosis
(Guergana Petrova, MD, PhD, Snezhina Lazova, MD, PhD, and Tsvetelina Velikova, MD, PhD, Pediatric Clinic, University Hospital Alexandrovska, Medical University of Sofia, Sofia, Bulgaria, and others)

Chapter 8. Multiple Sclerosis: Th17 Cells in Immunopathogenesis and Therapy
(Marina Ivanova, MD, Ivan Milanov, MD, PhD, Ekaterina Krasimirova, MD, PhD, Dobroslav Kyurkchiev, MD, PhD, and Tsvetelina Velikova, MD, PhD, Clinic of Neurology, University Hospital of Neurology and Psychiatry "St. Naum", Sofia, Bulgaria, and others)

Chapter 9. Inflammatory Bowel Disease in Children and Adolescents: Th17 Cells and Other Players
(Rayna R. Shentova-Eneva, MD, PhD, Department of Gastroenterology and Hepatology, University Children's Hospital, Sofia, Bulgaria, and others)

Chapter 10. Th17/Tregs Cells in Patients with Ulcerative Colitis during Anti-TNFα Therapy
(Tsvetelina Velikova, MD, PhD, Ekaterina Ivanova-Todorova, MD, PhD, Zoya Spasova, MD, PhD, Maria Petkova, MD, Ekaterina Krasimirova, MD, PhD, Kalina Tumangelova-Yuzeir, PhD, Georgi Vasilev, MD, Lyudmila Mateva, MD, PhD, Dobroslav Kyurkchiev, MD, PhD, Laboratory of Clinical Immunology, University Hospital “St. Ivan Rilski”, Department of Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria, and others)

Chapter 11. Th17 Cells Involvement in Celiac Disease
(Gergana Taneva, MD, and Tsvetelina Velikova, MD, PhD, Sveta Sofia Hospital, Bulgaria, Sofia, Bulgaria)

Chapter 12. Th17 Cells and Other Pathologies
(Tsvetelina Velikova, MD, PhD, Clinical Immunology, University Hospital Lozenetz, Medical Faculty, Sofia University, Sofia, Bulgaria)

Chapter 13. The Controversial Interaction between Th17 and T Regulatory Cells in Autoimmunity
(Tsvetelina Velikova, MD, PhD, Clinical Immunology, University Hospital Lozenetz, Medical faculty, Sofia University, Sofia, Bulgaria)

Index

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