Stefano Dall’Oglio, Anna D’Amico, Fabio Pioli and Sergio Maluta (Editors)
University Hospital, Verona, Italy

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

High-grade gliomas (HGG), glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) are still characterized by a dismal prognosis despite of recent advances in treatment options. Gold–standard therapy has involved maximum possible resection, followed by adjuvant irradiation plus TMZ followed by maintenance TMZ. TMZ has also proven its efficacy on tumors of oligodendroglial origin.

The conventional “5 out of 28 days” schedule of TMZ achieved an overall survival rate at 2 years of 26.5%; in patients with methylation of methylguanine methyltrasnsferase (MGMT) promoter, better results can be achieved but MGMT methylation status determination is feasible only in few centres. Dose–intensity TMZ schedules have the capability of depleting MGMT in tumor cells, thus promising a better outcome also in non – methylated patients. This new book discusses a possible rationale for intensified regimens of TMZ administration and reviews its possible benefits and risks, with a focus on results of clinical trials and reported toxicity cases. (Imprint: Nova Biomedical)