Systemic, Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders (Proceedings of I. Beritashvili Center for Experimental Biomedicine – 2015)

Nodar P. Mitagvaria, PhD (Editor)
Academician of the Georgian National Academy of Sciences, Professor, Dr. of Biol. Sc., Chairman of Scientific Council, Head, Dept. Blood Circulation and Metabolism, I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia

Series: New Developments in Medical Research
BISAC: MED075000

Clear

$230.00

eBook

Digitally watermarked, DRM-free.
Immediate eBook download after purchase.

Product price
Additional options total:
Order total:

Quantity:

Details

This book presents results of current research conducted in the I. Beritashvili Center of Experimental Biomedicine (former I. Beritashvili Institute of Physiology, Tbilisi, Georgia) and is devoted to the experimental investigation of systemic, cellular and molecular mechanisms of physiological functions and their disorders in pathology.

More precisely, the results of the following studies are described and discussed: The new, original theory of the fourth main state of an organism’s vitality; memory impairments following excitotoxic lesions; biologically positive behavioral indices of the transition state, caused by informational stress and their pharmacological regulation; functioning of mechanisms responsible for perception constancy; peculiarities of EEG characteristics in individuals with attention deficit hyperactivity disorder; neuroanatomy and neurochemistry of the basic mechanisms for neocortical and hippocampal arousal; changes in learning ability and induction of aggressive behavior caused by manganese loading and ionizing radiation; hippocampal activity during learning in different behavioral paradigms; molecular mechanism of PARP-1 action; significance of the diencephalic GABAergic neurons in normal and pathological activity of the brain; cellular mechanisms of antinociceptive tolerance; thermal stability of model globular protein; kinetic features of transport ATPases; antiseizure drugs and EEG in epileptic patients; effect of depakin on EEG epileptiform elements; how six domains form one enzyme; therapeutic potential of extracellular ubiquitin; effect of toluene chronic exposure on hippocampal structure; and the mechanisms of local hyperthermia caused by morphological changes in cerebral tissue. (Imprint: Nova Biomedical)

Preface

Chapter 1. Influence of Carbamazepine on Kindling Grades in Depressive and Non-Depressive Rats
Maia Barbakadze, Irina Bilanishvili, Nana Khizanishvili, Marika Chkhetiani, Irma Khachidze, and Alexander Koreli (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 2. Effect of Vasopressin on Conditional Reflex Elaboration
Nato Bukia, Marina Butskchrikidze, Lamara Machavariani, and Militsa Svanidze (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 3. Spatial Memory Impairments Following Excitotoxic Lesions of the Basal Forebrain Noncholinergic Neuronal Ensembles
Manana Dashniani, Maia Burjanadze, Maia Demurishvili, Nino Chkhikvishvili, Gela Beselia, Lali Kruashvili, Nino Pochkhidze, Temur Naneishvili, and Khatuna Rusadze (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 4. Biomolecular Charge Transfer Mechanisms at Gold Electrodes Modified by Self Assembled Monolayer Films
Tinatin D. Dolidze, Rudi van Eldik, David H. Waldeck, and Dimitri E. Khoshtariya (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 5. Biologically Positive Behavioral Indices of Transition State caused by Informational Stress and Their Pharmacological Regulation
Tamar Domianidze, Tamar Matitaishvili, Ia Labadze, and Michael Khananashvili (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 6. What Can Tell us the McCollough Effect about Functioning of Mechanisms of Perception Constancy?
Archil Kezeli, David Janelidze, Tina Kezeli, Manana Khomeriki, Tamar Lebanidze, and Natela Lomashvili (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 7. Antiseizure Drug and EEG in Epileptic Patients
Irma Khachidze, Victor Maloletnev and Manana Gugushvili (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 8. The Fourth Main State of Organism’s Vitality
Michael Khananashvili (I. Beritashvili Center of Experimental Biomedicine, Georgia)

Chapter 9. Detection of Genetically Modified Organisms by Multiplex PCR
Tamara Kutateladze, Inga Gabriadze, Boris Vishnepolsky, Marina Karseladze, and Nelly Datukishvili (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 10. Hippocampal Activity during Learning in Different Behavioral Paradigms
Liana Kvirkvelia, Gulkan Khikhadze, Marika Chkhetiani, and Lia Potolashvili (I. Beritashvili Center of Experimental Biomedicine, Georgia)

Chapter 11. Effect of Manganese Chloride Short-Term Administration on the Neonate and Mature Rats Learning Ability
Ilia Lazrishvili, Tamar Bikashvili, Asmat Shukakidze, Lia Gelazonia, and Nodar Mitagvaria (I.Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 12. Manganese Loading Cause Induction of Aggressive Behavior in Nonaggressive Rats
Ilia Lazrishvili, Tamar Bikashvili, Lia Gelazonia, Asmat Shukakidze, and Nodar Mitagvaria (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 13. Systemic Delivery of OrexinA (Hypocretin-1) and OrexinB (Hypocretin-2) Reveals Different Effectiveness on Behavior and Sleep-Wakefulness Cycle Structure and Total Time in Rats
Neli Maglakelidze, Eter Chijavadze, Mariam Babilodze, Eka Chkhartishvili, Olga Mchedlidze, Shorena Dzadzamia, Vera Tsomaia, Nino Rogava, and Nargiz Nachkebia (I. Beritashvili Center of Experimental Biomedicine, Georgia)

Chapter 14. Impact of Different Additives on the Thermal Stability of Model Globular Protein, á-Chymotrypsin
Maya Makharadze, Sophio Uchaneishvili, Mikhael Shushanyan, Tatyana Tretyakova, and Dimitri E. Khoshtariya (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 15. Attention Deficit Hyperactivity Disorder (ADHD): Peculiarities of EEG Characteristics in Preschool Age-Group Children
Victor Maloletnev, Manana Gugushvili and Irma Khachidze (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

Chapter 16. Typical Absence Seizures (TAS) Pattern in Combination with other Types of EEG Epileptiform Elements: Effect of Depakin
Victor Maloletnev, Manana Gugushvili and Irma Khachidze (I. Beritashvili Center of Experimental Biomedicine, Georgia)

Chapter 17. The Possible Mechanisms of Local Hyperthermia-Induced Morphological Changes in Cerebral Tissue (Experimental Study on Rats)
Nodar Mitagvaria, Marina Nebieridze, Marina Devdariani, Lena Davlianidze, Maka Mantskava, Nana Momtselidze, Lali Gumberidze, Ia Kvachakidze, and Nino Sikharulidze (I. Beritashvili Center of Experimental Biomedicine, Georgia)

Chapter 18. Neuroanatomy and Neurochemistry of the Basic Mechanisms for Neocortical and Hippocampal Arousal in Isolated Forebrain (Review)
Nargiz Nachkebia (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 19. Significance of the Diencephalic GABAergic Neurons in Normal and Pathological Activity of the Brain
Zakaria Nanobashvili, Tamar Chachua, Arkadi Surmava, Irine Bilanishvili, and Nadejda Khizanishvili (I. Beritashvili Experimental Biomedicine Centre, Tbilisi, Georgia, and others)

Chapter 20. The Effect of Ionizing Radiation on Aggressive Behavior in Rats, Physiological and Neurochemical Correlates
Marina Nikolaishvili, George Iordanishvili, David Nadareishvili, Tea Museliani, and Gogi Jiqia (I.Beritashvili center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 21. Kinetic Features of Transport ATPases
Eka Nozadze, Lia Shioshvili, Leila Tsakadze, Nana Arutinova, Marine Leladze, Sophio Dzneladze, and Gvantsa Chkadua (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 22. TRP Channels in Thermal Pain Sensation
Ivliane Nozadze, Nana Tsiklauri, Gulnazi Gurtskaia, Elene Abzianidze, and Merab Tsagareli (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 23. Manganism
Nikoloz Papuashvili, Tamila Bagashvili, Teimuraz. Jorbenadze, George Andronikashvili, Senera Chipashvili, Michael Okujava, and Tea Gurashvili (I. Beritashvili Center for Experimental Biomedicine, Georgia, and others)

Chapter 24. Transmembrane and Antimicrobial Peptides. Hydrophobicity, Amphiphilicity and Propensity to Aggregation
Malakia Pirtskhalava, Boris Vishnepolsky and Maia Grigolava (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 25. Ubiquitin Proteasome System in Norm and Pathology and Therapeutic Potential of Extracellular Ubiquitin
Rusudan Sujashvili and Irine Ioramashvili (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 26. Cellular Mechanisms of Antinociceptive Tolerance to Non-Steroidal Anti-Inflammatory Drugs
Nana Tsiklauri, Ivliane Nozadze, Natia Firkulashvili, Gulnazi Gurtskaia, Marina Nebieridze, Elene Abzianidze, and Merab Tsagareli (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 27. Molecular Mechanism of PARP-1 Action: How Six Domains Form One Enzyme
Tengiz Zaalishvili, Dina Margiani, Ketevan Kolkhidashvili, and Ketevan Kutalia (Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia)

Chapter 28. Toluene Chronic Exposure Alters Hippocampal Structure in Adolescent and Adult Brain (Experimental Study)
Mzia Zhvania, Nana Japaridze, Lela Chilachava, Lia Gelazonia, Nino Pochkhidze, Tamar Lordkipanidze, and Tamar Bikashvili (I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia, and others)

About the Editor

Index

The book is written for institutions and professionals (including including masters and doctoral students) working in the fields of general physiology, neurophysiology, biochemistry, biophysics, molecular biology, genetics, radiobiology, neuromorphology, behavior and memory, sleep and wakefulness, endocrinology, cell biology and bioinformatics

If you have any questions or comments with regards to this book, please fill out the form below. Thank you!

You have not viewed any product yet.