Synaptic Plasticity: Roles, Research and Insights

$195.00

Sraboni Chaudhury
University of Michigan, MI, US

Series: Neuroscience Research Progress
BISAC: MED057000

Synapse formation is the one of the unique features of brain cells (neurons), and synaptic plasticity remains the most pivotal function of the brain in response to synaptic activity by either intrinsic or extrinsic factor. Synaptic plasticity allows the brain to modulate wiring by regulating growth factors or neurotransmitters in response to any internal or external activity. Thus, alteration in synaptic plasticity in many brain regions allows the brain to modify several higher cognitive functions including learning and memory. In recent years, it has been observed that in many brain disorders there is a disruption in the genes as well as pre- and post-synaptic mechanisms which contribute to synaptic plasticity.

This book will give an overview of the fundamentals of synaptic plasticity in terms of its function in regulating growth factors, neurotransmitters and various associated receptors. It also summarizes the functional implication of disruption in synaptic plasticity in various disease conditions including neurodevelopmental diseases, psychiatric disorders, epilepsy, etc. It also highlights new advancements in terms of tools and techniques to understand synaptic plasticity. The advancement in techniques of microscopy, optogenetic and several electrophysiological techniques will help us in understanding synaptic plasticity in several brain regions, which will better explain the function of synaptic plasticity in different conditions including brain disorders.

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Table of Contents

Preface

Chapter 1. Experience-Dependent Synaptic Plasticity of Inhibitory Interneurons
(Vikram Sharma, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, US)

Chapter 2. An Integrated Mathematical Model of Synaptic Plasticity Induction by Postsynaptic Ca2+ Influx through the Interactions of AMPA and NMDA Receptors
(Florent Petitprez, Don Kulasiri and Jingyi Liang, Centre for Advanced Computational Solutions (C-fACS), Molecular Biosciences Group, Lincoln University, Christchurch, New Zealand, and others)

Chapter 3. Neuronal Plasticity and Experience-Dependent Behaviors: Insights from Fruit Flies
(Tuhin Subhra Chakraborty, Abu Farhan and Anindya Ganguly, University of Michigan, Ann Arbor, MI, US, and others)

Chapter 4. Synaptic Plasticity and Electrical Adaptation in Neurons
(Rakesh Kumar, PhD, Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden)

Chapter 5. Synaptic Plasticity in Autism Spectrum Disorders
(Meghna Saxena and Kapil Saxena, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, US, and others)

Chapter 6. Hippocampal Synaptic Plasticity Impairment in Fragile-X Syndrome
(Jana Gil-Mohapel, Division of Medical Sciences and UBC Island Medical Program, University of Victoria, Victoria, BC, Canada)

Chapter 7. The Role of Neurotrophic Factors in Regulating Synaptic Plasticity in Psychiatric Disorder
(Sraboni Chaudhury, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, US)

Chapter 8. Hippocampal Synaptic Plasticity: Insight of Epilepsy Progression, Development and Putative Targets for Treatment
(Manisha Shrivastav and Dilip Verma, Epilepsy Research Center, Westfälische Wilhelms-Universität, Münster, Germany, and others)

Chapter 9. Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram
(Anupratap Tomar and Lalitha Krishnan, Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Japan, and others)

Chapter 10. Tools and Techniques to Study Synaptic Plasticity
(Vivek Kumar and Shilpi Singh, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, US, and others)

Index

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