Synaptic Fundamentals of Memory Performance


Ignacio González-Burgos, PhD – Senior Researcher, Laboratorio “Burgos” de Investigaciones Psicobiologicas, Sierra de Bolanos, Mexico

Series: Neuroscience Research Progress
BISAC: MED057000

Memory could be conceptualized as the capability to encode, store and retrieve information to guide behavior. Memory may be stored in different manners depending on synaptic characteristics for information processing, which may modulate synchronization of firing of neuronal assemblies. This book focuses on some of the mechanisms that modulate the synaptic activity underlying both the organization and expression of memory.

Thus, memory is viewed from the point of view of its synaptic determinants. This book is the integrated compilation of a large body of experimental evidence related to some cellular and subcellular events underlying plastic changes of neural circuits forming the memory traces related to some memory systems. Moreover, this view of memory is considered from both a normal viewpoint and from that of some atypical situations.
(Imprint: Nova)

Table of Contents

Table of Contents


Chapter 1
Synaptogenes, Signaling Pathways and Intellectual Disability Syndromes
(Patricio Barros Núñez, Mónica Rosales Reynoso, and Berenice Ochoa Hernández, División de Genética, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social. Guadalajara, Jal. México)

Chapter 2
The Cellular and Molecular Mechanisms Driving the Estrogenic Modulation of Synaptic Activity in Mnemonic Information Processing
(Oscar González-Flores, Raymundo Domínguez-Ordóñez and Ignacio González- Burgos, Centro de Investigación en Reproducción Animal, UAT-CINVESTAV, IPN. Panotla, Tlaxcala. México, and others)

Chapter 3
The Molecular Biology of Dendritic Spine Plasticity in Memory Processing
(David González Tapia, Dulce A. Velázquez Zamora, and Ignacio González Burgos, Laboratorio de Psicobiología, División de Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS. Guadalajara, Jal. México, and others)

Chapter 4
Long-Term Potentiation and Long-Term Depression in Spatial Memory: An Update
(María Esther Olvera-Cortés, Miguel Ángel López-Vázquez, Blanca Érika Gutiérrez-Guzmán, J. Jesús Hernández-Pérez, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social. Morelia, Mich. México, and others)

Chapter 5
Consolidation, Retrieval, and Extinction: Dissimilar Molecular Requirements
(Sofía González-Salinas, Gina Lorena Quirarte, and Roberto Agustín Prado-Alcalá, Laboratorio de Aprendizaje y Memoria, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Qro. México)

Chapter 6
Memory in Music and Emotions
(Christian Mikutta, Werner K. Strik, Robert Knight, and Andreas Altorfer, University of California Berkeley, Helen Wills Institute of Neuroscience, Berkeley, CA, USA, and others)

Chapter 7
Estrogen Actions on Glial Reactivity and Inflammation-Mediated Memory Impairment: Sex Differences and Interaction with Other Neurotrophic Factors
(María José Bellini, Institute for Biochemical Research (INIBIOLP) – National University of La Plata, La Plata, Argentina)

Chapter 8
Neurotoxicity of Aβ Explained by its Association to Plasma Membranes
(Christian Peters, Eduardo Fernandez-Perez, Jorge Fuentealba, and Luis G. Aguayo, Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepción, Chile, and others)

Chapter 9
Cellular and Molecular Targets as Starting Points to Attenuate the Synaptic Failure in Alzheimer Beta Amyloid Toxicity: The Purinergic Transmission
(Jorge Fuentealba, Pamela Godoy, Tiare Silva-Grecchi, Francisco Saez-Orellana, and Luis G. Aguayo, Neuroactive Compound Screening Unit, Chile, and others)



“The book “Synaptic Fundamentals of Memory Performance, edited by Ignacio González-Burgos, is an enjoyable reading that covers a variety of complementary aspects on the molecular and cellular mechanisms involved in cognition and cognitive alterations. The book focuses on synapses. This is an excellent focus since synaptic function and plasticity is essential for the adequate processing of new information and to evoke stored information. The book reviews the molecular changes that determine the shape of dendritic spines and the generation of new synapses, which in turn modify synaptic information processing. The book presents persuasive arguments on the importance of the alterations in such molecular mechanisms as a cause of intellectual disabilities and provides a strong support for the role of synaptic mechanisms on memory. In addition, other interrelated and relevant aspects on the regulation of memory, such as the role of hormones and emotions, are also covered. In my opinion, the editor Ignacio González-Burgos has done an excellent job putting together a series of complementary chapters written by well recognized experts. The result is an excellent overview on the more recent developments on the molecular and cellular bases of memory performance.” – <strong>Reviewed by Luis M. Garcia-Segura, Instituto Cajal, Madrid, Spain</strong>

“<i>Synaptic Fundamentals of Memory Performance </i>by Gonzalez-Burgos and co-authors, provides timely fresh and novel approaches and findings regarding some characteristic events at synaptic level that support memory functioning: modulation of synaptic activity and the organization of mnemonic information in different memory systems. The focus of the book culminates by addressing some therapeutic targets at synaptic level in some memory dysfunction-associated neuropathologies such as Alzheimer’s disease.” – <strong>Reviewed by Alfredo Meneses, Department of Farmacobiology, CINVESTAV-IPN, México City, México</strong>

“<i>Synaptic Fundamentals of Memory Performance </i>edited by Ignacio González-Burgos spans across many exciting fields of learning and memory research in the brain, ranging from basic molecular mechanisms of neuronal plasticity, through hormone actions and the synapse to higher brain functions associating music and emotion, and concluding with molecular and cellular mechanisms impaired in Alzheimer’s disease. This is a wide spectrum of subjects indeed, and the Editor is doing his best to link them together and update the reader on recent developments in modern brain research.” – <strong>Reviewed by Menahem Segal, Department of Neurobiology, Weizmann Institute. Rehovot, Israel</strong>

“In this timely book, leading researchers address recent advances in the molecular mechanisms underlying memory. Written in a clear and concise style, it is readily understandable and will serve as a valuable resource for those engaged in neuroscience research as well as graduate students and advanced undergraduates in the fields of psychology and physiology. An important focus relating to current emphases on translational work, are chapters relating possible bases for cognitive impairments in various diseases or disability disorders. Indeed, this book elegantly posits that our understanding of cognitive processing has moved from substrates and engrams to the level of molecules.” – <strong>Reviewed by Victoria Luine, Distinguished Professor of Psychology, Hunter College of the City University of New York. USA</strong>

Additional Information

· Professionals in medical sciences mainly related with mental health.
· Psychologists and Psychiatrists.
· Neuroscience researchers and students.
· Universities and Institutes devoted to neuroscience research.
· Scientific societies

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