Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits

Nancy H. Phillips (Editor)

Series: Biochemistry Research Trends
BISAC: MED008000

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Superoxide dismutase (SOD) is an antioxidant enzyme that scavenges superoxide radicals, and are found in all living cells. SODs have been studied as a therapeutic tool for very diverse pathological situations for more than 30 years and, in many animal models and a few clinical trials, their use has shown positive outcomes. In this book, Chapter One begins with an overview of the association between manganese superoxide dismutase and cardiovascular disease. Chapter Two examines the indispensable roles of superoxide dismutation in mammalian erythrocytes. Chapter Three discusses the structure, catalysis and therapeutic uses of the Fe/Mn SOD family. Chapter Four reviews several strategies of nanomedicines development that have been used to prolong the circulation time and improve the therapeutic action of SODs. Chapter Five studies the emerging role of SOD3 in controlling skin inflammation and immune responses. (Imprint: Nova Biomedical)

Preface

Chapter 1. Manganese Superoxide Dismutase in Cardiovascular Disease
Yanqi Dang, Shuang Ling and Jin-Wen Xu (Interdisciplinary Institute for Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China)

Chapter 2. Indispensable Roles of Superoxide Dismutation in Mammalian Erythrocytes
Takujiro Homma and Junichi Fujii (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Iidanishi, Yamagata, Japan)

Chapter 3. The Family of Fe/Mn Superoxide Dismutase: Structure, Catalysis and Therapeutic Uses
Rosalin Bonetta, Gary J. Hunter and Thérèse Hunter (Laboratory of Protein Science and Biochemistry, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta, and others)

Chapter 4. Nanomedicines as a Strategy For The Therapeutic Use Of Superoxide Dismutases
M. Luisa Corvo, H. Susana Marinho and M. Barbara F. Martins (Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto, Lisboa, Portugal and Departamento de Farmácia Galénica e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto, Lisboa, Portugal, and others)

Chapter 5. Emerging Role of Superoxide Dismutase 3 in Controlling Skin Inflammation and Immune Responses
Shyam Kishor Sah and Tae-Yoon Kim (Catholic Research Institute of Medical Science, Laboratory of Dermato-Immunology, The Catholic University of Korea, Banpo-dong, Seocho-gu, Seoul, Republic of Korea

Index

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