Sulfated Polysaccharides

Miguel Gama
Minho University, Biological Engineering Department, Braga, Portugal

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI007000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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In the post-genomic era, science is still challenged to explain the biosynthesis of complex polysaccharides and glycoconjugates. Unlike nucleic acids and proteins, the information needed for their biosynthesis is not clearly contained to this day within the genome of the various organisms. This means that no biosynthetic code has been revealed yet. As a result, there will be millions of structurally distinct, functional chemical species at the end of their biosynthesis.

This book offers an up-to-date view on sulfated polysaccharide structure and function state of the art in different life kingdoms: bacteria, protista, plantae, fungi and animalia. The structure, activities and current thinking on the interplay between these two vital features (as well as ways to study them) are reviewed in the present book. The growing economical interest in sulfated polysaccharides due to their potential biotechnological use in different areas, such as pharmaceutical and food industries, are also commented on. The information within the chapters adds to other prior available literature; the intention of the authors was to extend and further develop the discussions related to glycobiology.
(Imprint: Nova)

Preface

Abbreviations and Acronyms

Chapter 1 - Heparan Sulfate and Heparin: Structure and Function
(Marcelo A Lima, Renan P Cavalheiro, Maria CZ Meneghetti, Leonardo TDB Nobre, Gustavo M Viana, Edwin A Yates and Helena B Nader, Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil, and others)

Chapter 2 - Chondroitin and Keratan Sulfate
(Shunji Tomatsu, Tsutomu Shimada, Pravin Patel, Robert W. Mason, Tadahisa Mikami, Hiroshi Kitagawa, Tomoya Akama, Adriana M. Montano, and Tadao Orii, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA, and others)

Chapter 3 - Characterization and Chemical Modification of Glycosaminoglycans of the Extracellular Matrix
(Schiller J, Becher J, Möller S, Lemmnitzer K, Riemer T, Schnabelrauch M, University of Leipzig, Medical Faculty, Institute of Medical Physics and Biophysics, Haertelstrasse, Leipzig, Germany, and others)

Chapter 4 - Unusual Heparin-Like Compounds from Marine Invertebrates
(Suely Ferreira Chavante, Adriana da Silva Brito, Rômulo dos Santos Cavalcante and Giulianna Paiva Viana de Andrade, Laboratório de Glicoconjugados Bioativos (GLICOBIO), Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte (UFRN), Natal/RN, Brazil, and others)

Chapter 5 – Heparan/Heparin Polysaccharide Synthesis: Visiting the Chemoenzymatic Synthesis
(Hugo Alexandre Oliveira Rocha, Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte (UFRN), Natal/RN, Brazil)

Chapter 6 - Sulfated Polysaccharides from Green Seaweed
(Anabela Alves, Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal)

Chapter 7 - Fucoidans and Fucans
(Pilar Rupérez, Metabolism and Nutrition Department. Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN). Consejo Superior de Investigaciones Científicas (CSIC). José Antonio Novais 10, Ciudad Universitaria, Madrid, Spain)

Chapter 8 - Carrageenans
(Cinthia Beatrice Silva Telles, Moacir Fernandes Queiroz, Jailma Almeida-Lima and Hugo Alexandre Oliveira Rocha, Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte (UFRN), Natal/RN, Brazil)

Chapter 9 - Agarans: Sulfated Precursors and Derivatives from Agarose, and Related Sulfated Galactans
(Marina Ciancia and María Cristina Matulewicz, Cátedra de Química de Biomoléculas, Departamento de Biología Aplicada y Alimentos, Facultad de Agronomía, Universidad de Buenos Aires, San Martín, Buenos Aires, Argentina)

Chapter 10 - Sulfated Polysaccharides from Unusual Natural Sources
(Marília Medeiros Fernandes de Negreiros, Jailma Almeida-Lima and Hugo Alexandre Oliveira Rocha, Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte (UFRN), Natal/RN, Brazil)

Chapter 11 - Methods of Characterization of Sulfated Oligo-Polysaccharides
(Annamaria Naggi and Giangiacomo Torri, Istituto di Ricerche Chimiche e Biochimiche “G. Ronzoni”, Milan, Italy, Milano, Italy)

Chapter 12 - Sulfated Polysaccharides and Nanotechnology
(Vera Carvalho, Francisco Miguel Gama, Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal)

About the Editors

Index

Broad audience: from biologist to chemists. The book covers topics for both undergraduate and graduate students.

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