Sudden Death: Causes, Risk Factors and Prevention


Jiashin Wu (Editor)
USF Medicine International, University of South Florida, Tampa, Florida, USA

Jessica Wu (Editor)

Series: Cardiology Research and Clinical Developments, Public Health in the 21st Century
BISAC: MED010000

This book dedicates the first seven chapters to cardiac electrophysiological dysfunction that can lead to ventricular fibrillation and sudden death. The next six chapters expand the topics of sudden death to other causes. Brugada Syndrome is the top cause of non-traumatic sudden death in young males of Southeastern Asian and southern European origins. Chapters One and Two review extensively the history and current status, mechanisms of arrhythmias and related gene mutations in Brugada Syndrome, and discuss gaps in the current knowledge. Chapter Three presents clinical studies on the A1180V and R1193Q mutations of the cardiac sodium channel gene, SCN5A.

The authors identified R1193Q mutation in 12.8%-16% of a healthy Chinese population. This result prompted the question of whether SCN5A mutations are still the top genetic bases of Brugada and long QT syndromes. Chapters Four, Five and Seven discuss the pathophysiology causes, risk factors, predictors, prevention and possible therapeutical strategies of sudden cardiac death. Chapter Six reviews the scope and causes of sudden cardiac death in athletics. Chapter Seven is dedicated to the roles of electrical cardiac systole in sudden death. Chapter Eight reviews sudden death related to cardiac and brain tumors, pulmonary tumor embolism, asphyxia, massive exsanguinations and their pathophysiology.

Chapter Nine summarizes the pathophysiology of sudden death caused by myocardial tuberculosis. Chapter Ten introduces pathophysiology of sudden death during hot baths in deep bathtubs, which occurs frequently in elderly people in Japan. Chapter Eleven discusses air pollution as a trigger of sudden death. Chapter Twelve presents biochemical, cytological and histopathological examination of sudden unexpected death in infancy. The last chapter of the book, Chapter Thirteen, reviews postmortem cardiac markers in different body fluids and their application in forensic pathology diagnosis of sudden cardiac death. In combination, these chapters cover a broad range of topics about sudden death. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1. A Rare Lethal Syndrome in Search of its Identity: Sudden Death, Right Bundle Branch Block and ST Segment Elevation
(Bortolo Martini, Jiashin Wu, Andrea Nava, Boldrini Hospital, Thiene, Italy, and others)

Chapter 2. Experimental Mechanisms of Arrhythmias in Brugada Syndrome (Hiroshi Morita, Douglas P. Zipes, Jiashin Wu, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan, and others)

Chapter 3. SCN5A Variants and Sudden Cardiac Death
(Aijun Sun, Lei Xu, Cheng Shen, Junbo Ge, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China)

Chapter 4. Predictors and Prevention of Sudden Cardiac Death.
(Yumei Hou, Jialu Hu, Indra Prasad Upadhyay, Zengyong Qiao, Ling Zhang, Sunny S. Po, University of Oklahoma Health Sciences Center, USA)

Chapter 5. Pathophysiology, Risks, Preventive and Therapeutic Strategies in Sudden Cardiac Death
(Shyam Gelot, Catherine Law, Srinivas M. Tipparaju, University of South Florida, USA)

Chapter 6. Sudden Cardiac Death in Athletics: Scope of the problem and emergency response
(Eric E. Coris, Steve Walz, Frances Sahebzamani, Anne Curtis, Eduardo Gonzalez, Leon Anijar, Kira Zwygart, University of South Florida, University of Buffalo, USA)

Chapter 7. The Roles of Electrical Cardiac Systole in Sudden Death (F.R. Breijo-Marquez, M. Pardo Rios, Commemorative Hospital, Boston, USA, and University of Murcia, Spain)

Chapter 8. Neoplasm-related Sudden Death: Causes and Clinicopathological Characteristics
(Katsuya Chinen, Nerima General Hospital, Tokyo, Japan)
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Chapter 9. Sudden Death Related to Myocardial Tuberculosis
(Valentina Gabbolini, Anna Laura Santunione, Enrico Silingardi, University of Modena and Reggio Emilia, Italy)
<a href=”” target=”_blank” rel=”noopener”>Free Download Available</a>

Chapter 10. Bath-Related Sudden Death
(Takahisa Okuda, Seiji Shiotani, Nippon Medical School, Japan, and Tsukuba Medical Center, Japan)

Chapter 11. Sudden Death and the Effects of Particulate Matter Air Pollution
(Na Zheng, Shantou University Medical College, China)

Chapter 12. Biochemical, Cytological and Histopathological Examination of Sudden Unexpected Death in Infancy
(Iwao Emura, Japanese Red Cross Nagaoka Hospital, Japan)

Chapter 13. Diagnostic Efficacy of Biochemical Markers in Sudden Cardiac Death
(Esperanza Navarro Escayola, The Institute of Legal Medicine, Spain)


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