Structure and Function of Cytochromes

$230.00

Elaine J. Mathis (Editor)

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI049000

This book contains five chapters exploring the structure and function of cytochromes, which are redox-active proteins that contain a heme with a central Fe atom at its core as a cofactor. Chapter One explores the functional relevance of cytochrome c-oxidase subunit IV isoform expression for cellular energy sensing, ATP production, and oxidative stress levels and its role in neurodegeneration. Chapter Two deals with the factors determining the orientation of ligated histadines in hemoproteins, cytochromes, and model systems. Chapters Three and Four include comparative studies of native and synthetic cytochrome b. Lastly, Chapter Five discusses some examples of synthetic and native cytochromes used as central components of biosensors in bioelectronic/biocatalytic applications.

Clear

Table of Contents

Preface

Chapter 1. Cytochrome C-Oxidase as a Neuroprotective Target
Joseph Allison¹, Ana Jimenez², Victor Echeverry², Sara Uceda² and Natalia Arias²,³,4
¹Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
²Department of Psychology, Faculty of Life and Natural Sciences, BRABE Group, University of Nebrija, Madrid, Spain
³Institute of Neurosciences of the Principality of Asturias (INEUROPA), Spain
4Health Research Institute of the Principality of Asturias, Spain

Chapter 2. Factors Determining the Orientation of Ligated Histidines in Hemoproteins, Cytochromes, and Model Systems
Dragan M. Popović and Ivana S. Đorđević
University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Belgrade, Serbia

Chapter 3. Comparative Study on Structure-Function Correlation of Native and Synthetic Cytochrome b: Protonation and Redox Properties
Dragan M. Popović
Department of Chemistry, University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Belgrade, Serbia

Chapter 4. Comparative Study of Native and Synthetic Cytochrome b: Modeling, Dynamics, and Bioinformatics Study
Dragan M. Popović
Department of Chemistry, University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Belgrade, Serbia

Chapter 5. Redox Properties of Small Synthetic Hemoproteins and Native Enzymes for Application in Bionanotechnology and Bioelectronic Devices
Dragan M. Popović
Department of Chemistry, University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Belgrade, Serbia

Index