Streptozotocin: Uses, Mechanism of Action and Side Effects

Elizabeth L. Gauthier (Editor)

Series: New Developments in Medical Research
BISAC: MED058170



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Streptozotocin (STZ), an antibiotic and anticancer agent, is the most prominent diabetogenic chemical agent in diabetes research due to its cytotoxicity in pancreatic beta-cells. The selective toxicity of STZ due to beta cells occurs because of its preferential accumulation in beta cells through uptake via GLUT2 glucose transporter.

Insulin dependent diabetes mellitus can be induced by either single high dose or multiple low- dose STZ injections. At low dose, STZ induces pancreatic beta-cell apoptosis and at high dose it causes necrosis. Though STZ itself can cause carcinogenesis and renal, hepatic and muscle myoblast toxicity, these side effects can be minimized or completely avoided by using lower doses. This book discusses in further detail the different ways in which streptozotocin is used in the medical field. (Imprint: Nova Biomedical )


Chapter 1. Streptozotocin as a Tool to Induce Central Pathology and Cognitive Impairment in Rodents
Monica Garcia-Alloza (Division of Physiology. School of Medicine University of Cadiz, Cádiz, Spain)
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Chapter 2. Use of Streptozotocin in Experimental Type 1 Diabetic Models
Jing Zhang and Laura R. McCabe (Bone and Joint Research Center, Xi’an Jiaotong University, Xi'an, Shaanxi, People's Republic of China)

Chapter 3. Cognitive Impairment Induced by Streptozotocin: An Experimental Link between Diabetes and Alzheimer’s Disease
Patrícia Nardin, Ana Carolina Tramontina, Patrícia Sesterheim, Leticia Rodrigues, Regina Biasibetti and Carlos-Alberto Gonçalves (Biochemistry Department of Federal University of Rio Grande do Sul (UFRGS), Porto Alegre Brazil)

Chapter 4. Streptozotocin-Induced Rodent Models of Diabetes: Protocol Comparisons
Renata O. Samuel, João E. Gomes-Filho, Eloi Dezan-Júnior and Luciano T. A. Cintra (Faculdade de Odontologia de Araçatuba, UNESP Univ Estadual Paulista, Departamento de Odontologia Restauradora, São Paulo, Brazil)

Chapter 5. Matrix Metalloproteases in Streptozotocin Model of Diabetes Mellitus
Giovani B. Peres, Miriam G. Jasiulionis and Yara M. Michelacci (Departamento de Bioquímica, Departamento de Farmacologia, Escola Paulista de Medicina, São Paulo, Brazil)
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Chapter 6. Genotoxic Effects of Streptozotocin
Alejandro D. Bolzán (Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biología Celular, La Plata, Argentina)

Chapter 7. Toxic Effect of Streptozotocin (STZ) on the Hepatobiliary Function: Oxidative Stress and Inflammation may Contribute to the Hepatic Complications during STZ-Induced Insulin-Dependent Diabetes
C. E. Carnovale, D. E. Francés, P. I. Ingaramo and M. T. Ronco (Instituto de Fisiología Experimental (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina)


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