Stem Cells in Disease Pathogenesis


Prasad S. Koka (Editor)

Series: Stem Cells – Laboratory and Clinical Research

BISAC: MED107000

The normal functioning of the human female reproductive system is sacrosanct, as it allows for the essential nurturing of offspring. Conditions such as endometriosis and fibroid formation can have devastating consequences to the progeny, as well as the parents, both physically and mentally. This book has several chapters that deal with the role of stem cells in the safer outcome of pregnancies.

Mesenchymal stem cells continue to make waves as various researchers dwell on their low immunogenicity to prevent graft rejection when used for therapeutic strategies.
Dental pulp-derived stem cells are being sought after to address many therapies. However, researchers must exercise ethical caution to avoid resorting to pulling out the teeth of live, healthy animals, including those qualified for pets.

The efficacy of cancer treatments with naturally occurring plant-derived substances and the characterization of cancer stem cells and lesions continue to engage researchers of this ever-perennial disease and its potentially lethal pathology.

Stem cells to replenish the pancreatic islet cells from induced pluripotent stem cells are an actively pursued subject in regenerative medicine for diabetes patients. Stem cells in immune responses are also attracting researchers to investigate immune tolerance and autoimmunity.

Table of Contents


Chapter 1. Stem Cells of Female Reproductive System: Endometrium vs Fallopian Tube
(Indumathi Somasundaram, Pankaj Mahipatrao Kaingade, Apurva Birajdar, Rakesh Sharma and Dhanasekaran Marappagounder – Department of Stem cell and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, India, et al.)

Chapter 2. Anti-angiogenic Potential of Itraconazole and Its Reversal by Endometrial Stem Cells Using Chick Embryo Model
(Indumathi Somasundaram, Apurva Birajdar, Priyanka Hilage and R. K. Sharma – Department of Stem cells and Regenerative Medicine, Centre for Interdisciplinary Research, D. Y. Patil University, Kolhapur, India, et al.)

Chapter 3. Intrauterine Infusion of Human Autologous Peripheral Blood Mononuclear Cells Improves In Vitro Fertilization Success in Infertile Women
(Swarup K. Chakrabarti, Sanghamitra Ghosh, Shovan D. Kalapahar, Gunja Bose, Saeeda Wasim, Tushar K. Das, Ratna Chattopadhyay, and Baidyanath Chakravarty – Institute of Reproductive Medicine, Salt Lake, Kolkata, India)

Chapter 4. Development and Characterization of Hematopoietic Stem Cells from Human Embryonic Stem Cells
(Nalini J. Gupta, Swarup K. Chakrabarti, Minal Trivedi, Gopal Pande, Ratna Chattopadhyay, Lalji Singh, and Baidyanath Chakravarty – Institute of Reproductive Medicine, Indian Council of Medical Research, Salt Lake, Kolkata, India, et al.)

Chapter 5. Mutation Analysis of MTHFR Gene in Indian Women with Unexplained Recurrent Miscarriages; Folic Acid Supplementation Improves Pregnancy Outcomes
(Nalini J. Gupta, Gaurav Gupta, Swarup K. Chakrabarti, Kumarasamy Thangaraj, Lalji Singh and Baidyanath Chakravarty – Institute of Reproductive Medicine, Kolkata, India, et al.)

Chapter 6. Comparison of the Proliferation Potential of Bone Marrow and Adipose- Derived Mesenchymal Stem Cells Cultivating on Human Amniotic Membrane
(Fereshteh Dorazehi, Mohammad Nabiuni, Hanieh Jalali and Raziyeh Keshavarzi – Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran, et al.)

Chapter 7. Efficacy of the Mesenchymal Stem Cells Therapy Combined with Core Decompression in Avascular Necrosis of the Femoral Head. A Systematic Review and Meta-analysis of Clinical Trials
(Gonzalo Mariscal, Pablo Martinez-Calabuig, Rafael Lorente, Joaquín Alfonso-Beltrán, Jose Enrique de la Rubia, Carlos Barrios and Pedro Domenech-Fernández – Institute for Research on Musculoskeletal Disorders, Valencia Catholic University, Valencia, Spain, et al.)

Chapter 8. Proliferation Capacity and Osteogenic Potential of Human Gingival Stem Cells versus Human Dental Pulp Stem Cells
(Amany Hany Mohamed Kamel, Samia Moustafa Kamal, Laila Ahmed Rashed and Nermeen El-moataz Bellah Ahmed – Department of Oral Biology, Faculty of Dentistry, Cairo University, Egypt, et al.)

Chapter 9. Comparison between the Effect of MTA and Biodentine on Proliferation and Odontogenic Differentiation of Dental Pulp Stem Cells (In Vitro Study)
(Reham Mohamed Ali Abd El Latif, Maha Ibrahim Abdelfattah, Eman Hassan Anwar Aboul-Ezz, Mohamed Sherif Mohamed Salah El Din and Wael Mahmoud Abd Al Khalek – Pediatric, Preventive Dentistry and Dental Public Health, Faculty of Dentistry, Suez Canal University, Egypt, et al.)

Chapter 10. The Monomeric Resins TEGDMA and HEMA Regulate the Transcriptional Control of Matrix Metalloproteinases MMP-2 and MMP-9, in Human Pulp Fibroblasts and Mesenchymal Stem Cells
(A. Procino and I. Feliciello – Department of Pharmacy, University of Salerno, Fisciano, Italy, et al.)

Chapter 11. Effect of Dental Stem Cells on T Cell Proliferation
(Maha Ibrahim Abdelfattah, Phoebe Magdy Abd El-Massieh and Riham Mohamed Aly – Department of Oro-dental Genetics, Medical Research Centre of Excellence, National Research Centre, Cairo, Egypt, et al.)

Chapter 12. Amount of Bone Morphogenetic Protein-2, Epidermal Growth Factor, and Vascular Endothelial Growth Factor in Adipose Tissue, Umbilical Cord, and Bone Marrow Mesenchymal Stem Cell Derived Secretome: An In-Vitro Study
(Ismail Hadisoebroto Dilogo, Jeanne Adiwinata Pawitan, Jephtah Furano Lumban Tobing, Jessica Fiolin and Evah Luviah – Department of Orthopaedic and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, et al.)

Chapter 13. Identified Cancer Stem Cells (CSCs) in Ex- Vivo Cultured Acute Lymphoid Leukemia (B-ALL) Cells
(Echambadi Loganathan Samundeshwari, Lokanathan Srikanth, Sireesha K, Kattaru Surekha, Chodimella Chandrasekhar, Mangu Hanumantha Rao, Bhuma Vengamma and Potukuchi Venkata Gurunadha Krishna Sarma – Stem Cell Laboratory, Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences, Tirupati. India)

Chapter 14. Role of Simarouba glauca DC Plant in Cancer: A Short Review
(Patil Dhanashri, N. J. Patil, S. V. Ullegaddi, P. Nelaturi and P. Kiranmayee – Department of Integrative Medicine, Sri Devaraj Urs Academy of Higher Education & Research, Kolar (Sduaher), Karnataka, India, et al.)

Chapter 15. Study of Histomorphological Spectrum of Thyroid Lesions in Thyroidectomy Specimens, Along with Cytological Correlation. Cross Sectional Study from 2015 to 2018
(Shilpa S. Bilagi and R. V. Ramteke – Rajarshee Chhatrapati Shahu Maharaj Government Medical College, Kolhapur, Maharashtra, India)

Chapter 16. Generation of Pancreatic β Cells from Peripheral Blood Mononucleocytes Derived Induced Pluripotent Stem Cells
(R. M. Aly, M. M. Ellithy, N. E. M. B. Ahmed, M. H. Zaazou, N. L. Soliman, M. M. El Batran, E. A. Abbas and E. H. Aboul-Ezz – Basic Dental Science Department, National Research Centre, Cairo, Egypt, et al.)

Chapter 17. Stem Cells: An Exciting Avenue for Diabetes Mellitus
(Abhishek S. Kuwar, Shivani Desai, Ramesh R. Bhonde and Sarika R. Metkar – Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Department of Pharmacology, Pimpri, Pune, Maharashtra, India, et al.)

Chapter 18. Regeneration’s Role in the Development of Desensitization and Immunological Tolerance
(A. V. Pechersky, V. I. Pechersky, V. N. Velyaninov, O. V. Pecherskaya and V. F. Semiglazov – North-West State Medical University named after I. I. Mechnikov, St. Petersburg, Russia, et al.)

Chapter 19. Features of the Immune Response to One’s Own Antigens and Foreign Antigens
(A. V. Pechersky, V. I. Pechersky, O. V. Pecherskaya and V. F. Semiglazov – North-West State Medical University named after I. I. Mechnikov, St. Petersburg, Russia, et al.)

Chapter 20. Regenerative Approach to the Treatment of COVID-19 Patients
(Swarup K. Chakrabarti and Manibrata Paul – Stembionics Private Limited, Kolkata, India)

Chapter 21. Medical Applications of Infrared Thermography: A Narrative Review
(Nishitha Jasti, Suman Bista, Hemant Bhargav, Sanjeev Sinha, Sushil Gupta, S. K. Chaturvedi and B. N. Gangadhar – NIMHANS Integrated Centre for Yoga, National Institute of Mental Health and Neurosciences, Hosur Main Road, Bengaluru, et al.)


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