Statins: Pharmacology, Clinical Implications and Adverse Effects

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Benedetta La Grua (Editor)
Alessandro Molinelli (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation, Biochemistry Research Trends
BISAC: MED071000

Statins work by reducing cholesterol synthesis by inhibiting the enzyme HMG-CoA reductase. The decrease in cholesterol levels is associated with increased expression of receptors of hepatocytes, with a greater extraction of plasma LDL-C and a lower diffusion of it into the tissues. In this book, the authors present current research in the study of the pharmacology, clinical implications and adverse effects of statins. Topics include the pleiotropic effects of statins beyond cholesterol lowering; anti-inflammatory activity of statins in asthma and COPD; statins as anticancer agents; statin use in patients with carotid disease; and the Alzheimer’s disease risk-lowering effect of lipophilic statins. (Imprint: Nova Biomedical )

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Table of Contents

Preface

Statins Use: Clinical Implications in Patients with Carotid Disease
(Paola De Rango, Enrico Cieri, Luca Farchioni, Alessandra Manzone, Paolo Bonanno, Fabio Verzini, Vascular and Endovascular Surgery, Hospital S.M.Misericordia, Perugia, Italy)

Statins: Their Pleiotropic Effects Beyond Lowering Cholesterol
(Shouji Shimoyama, Gastrointestinal Unit, Settlement Clinic, Towa, Adachi-ku, Tokyo, Japan)

Anti-Inflammatory Activity of Statins in Asthma and COPD
(Kittipong Maneechotesuwan, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand)

Statins as Anticancer Agents
(Paul W. Sylvester, Abhita Malaviya, Suryatheja Ananthula, Parash Parajuli, Roshan V. Tiwari, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA)

Relevant Aspects of the Pleiotropic Properties and Review of Adverse Effects
(Jaime Gulín Dávila, Paloma Sempere Serrano, Antonio García Sabina, Pharmacy Service, Lucus Augusti Hospital, Lugo, Spain)

Statins: Pharmacology, Clinical Implications and Adverse Effects
(Novo Salvatore, Mignano Antonino, Chair of Cardiovascular Diseases, Centre for the Early Diagnosis of Preclinical and Multifocal Atherosclerosis and for Secondary Prevention, Division of Cardiology, University Hospital “Paolo Giaccone”, University of Palermo, Italy)

Commentary:
Alzheimer’s Disease Risk-Lowering Effect of Lipophilic Statins
(Elisa Biondi, Facoltà di Scienze Biologiche, Università di Torino, Torino, Italy)

Index

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