Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes


Eric R. Travers (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

Statins are well-known drugs to lower cholesterol levels and play an important role in the prevention of cardiovascular diseases. They inhibit hydroxymethylglutaryl–coenzyme A (HMGCoA) reductase, an enzyme that plays a central role in the production of cholesterol in the liver. Despite the growing experience in the use of statins, it is still difficult to predict the individual patient response in term of efficacy and possible adverse effects. This book discusses several medical uses for statins. It also discusses the mechanisms of action and clinical outcomes of using statins. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1- Statin Treatment in Experimental Lipemia and Atherosclerosis: The Similarities and Differences with Humans (pp. 1-26)
Thomas P. Johnston and Tatyana A. Korolenko (Division of Pharmaceutical Sciences,
University of Missouri-Kansas City, Kansas City, Missouri, US and Institute of Physiology and Fundamental Medicine, Siberian Branch of the RussianAcademy of Medical Sciences, Novosibirsk, Russia)

Chapter 2- Statins: Potentially Neuroprotective Agents (pp. 27-37)
Sergey V. Pisklakov and Anuradha Patel (Neuroanesthesia Service, Clinical Competence Committee, Department of Anesthesiology and Perioperative Care,New Jersey School of Medicine, Newark, New Jersey, US and Pediatric Anesthesia, Department of Anesthesiology and Perioperative Care, New Jersey School of Medicine, Newark, New Jersey, US)

Chapter 3- Statins: Pharmacology, Medical Uses and Clinical Outcomes (pp. 39-79)
Isabelle De Loecker (Erasme Hospital, Brussels, Belgium)

Chapter 4- Statins and the Brain: Good, Bad or Both? (pp. 81-104)
Simran D. S. Maggo and John C. Ashton (Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand)

Chapter 5- Statins in Cardiac Surgery: The Current Evidence (105-124)
Elmar W. Kuhn, Yeong H. Choi, Thorsten Wahlers, and Oliver J. Liakopoulos (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Germany and Department of Thoracic and Cardiovascular Surgery, West-German Heart Center Essen, Germany)

Chapter 6- The Role of Statin Therapy in Children (pp. 125-143)
Karen King, Alan Macken, Michael B. O’Neill and Clodagh S. O’Gorman (University of Limerick, Limerick, Ireland)

Chapter 7- Statins and Portal Hypertension (pp. 145-164)
Gonzalo Ramírez, Jimmy Briceño and Armando Rojas (Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile)

Chapter 8- Molecular Mechanisms Behind the Beneficial Effects of Statins in Ovarian Cancer (pp. 165-182)
Mauricio A. Cuello, Sumie Kato and Lorena Abarzúa-Catalán (Division of Obstetrics and Gynecology Faculty of Medicine, School of Medicine, Pontificia Universidad Católica de Chile,
Santiago, Chile)\

Chapter 9- Statin-Induced Myopathy (pp. 183-195)
Marilita Falangola Accioly and Camila Ferreira Leite (Department of Applied Physical Therapy,
Federal University of Triângulo Mineiro, UFTM, Uberaba-MG, Brazil and Postgraduate Program in Health Sciences, Federal University of Triângulo Mineiro, UFTM, Uberaba-MG, Brazil)

Chapter 10- Statins: Diabetogenicity is Weak, but an Antiathelogenic Effect is More Real (pp. 197-208)
Shouji Shimoyama (Gastrointestinal Unit, Settlement Clinic, Towa, Adachi-ku, Tokyo, Japan)


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