Sphingolipids: Biology, Synthesis and Functions

Angel Catalá, PhD (Editor)
Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, CIC., La Plata, Argentina

Series: Biochemistry Research Trends
BISAC: SCI007000




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This book presents an overview of sphingolipids: biology, synthesis and functions. The topics analyzed in this book cover a broad spectrum of functions played by sphingolipids including: the role of sphingomyelin in the regulation of membrane physical state; tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity to insulin action; sphingolipid diversity, biosynthesis and regulation; metabolism of glycolipids at the cell’s surface: modulation and functional implications; the specific role of sphingomyelins in cell physiology; the role of sphingosine-based lipids using sphingolipidomics; sphingolipids and ceramides of aqueous humor and trabecular meshwork; the effect of membrane microdomains containing sphingolipids on lipid peroxidation; and roles of sphingolipids in skeletal development and homeostasis.
(Imprint: Nova)

pp. vii-xi

Chapter 1
The Role of Sphingomyelin in the Regulation of Membrane Physical State
(Stefano Piotto, Lucia Sessa, Simona Concilio, Department of Pharmacy, University of Salerno, Fisciano (SA), Italy, and others)
pp. 1-20

Chapter 2
Tricyclic Antidepressants are Modulators of Sphingolipid Turnover and Cell Sensitivity to Insulin Action
(Nataliya A. Babenko, Department of Physiology of Ontogenesis, Institute of Biology, Kharkov Karazin National University, Kharkov, Ukraine)
pp. 21-38

Chapter 3
Sphingolipid Variety, Biosynthesis and Regulation
(Diana Molino, Jean-Denis Faure, Ecole Normale Supérieure-PSL Research University, Département de Chimie, Sorbonne Universités - UPMC Univ Paris, Paris, France, and others)
pp. 39-66

Chapter 4
Metabolism of Glycolipids at the Cell Surface
(Jose L. Daniotti, Aldo A. Vilcaes, Macarena Rodriguez-Walker and Fernando M. Ruggiero, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC, UNC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina)
pp. 67-90

Chapter 5
Unraveling the Specific Role of Sphingomyelins in Cell Physiology: Where Are We?
(Joan Bestard-Escalas, María Dolores Ledesma, Makoto Taniguchi, Toshiro Okazaki, María Laura Martin and Gwendolyn Barceló-Coblijn, Research Unit, Hospital Universitari Son Espases, Institut d’Investigació Sanitària de Palma (IdISPa), Ctra. Valldemossa, Palma, Balearic Islands, Spain, and others)
pp. 91-128

Chapter 6
Unravelling the Role of Sphingosine-Based Lipids using Sphingolipidomics
(M Rosário M Domingues, Ana Reis, Daniela Couto, Pedro Domingues, Mass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, Campus Universitario de Santiago, Aveiro, Portugal)
pp. 129-152

Chapter 7
An Overview of Sphingolipids and Ceramides of Aqueous Humor and Trabecular Meshwork
(Yenifer Guerra, Katyayini Aribindi, Nawajes A. Mandal, Sanjoy K. Bhattacharya, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA, and others)
pp. 153-164

Chapter 8
Roles of Sphingolipids in Skeletal Development and Homeostasis
(Garthigha Manickam, Jingjing Li, Faculty of Dentistry, McGill University, Montreal, Canada, and others)
pp. 165-176

Chapter 9
The Effect of Membrane Microdomains Containing Sphingolipids on Lipid Peroxidation
(Angel Catalá, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, (INIFTA-CCT La Plata-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina)
pp. 177-186

Editor Contact Information
pp. 187

pp. 189-191

Audience: Medical Doctors, Biochemist, Biologists, Medical Schools, Biochemistry Schools Universities
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