Details

Recent advances in molecular and structural glycobiology have shown that a variety of lectins recognize partially trimmed intermediates of the high-mannose-type oligosaccharides and thereby determine the fates of their carrier proteins in cells. The carbohydrate recognition domains (CRDs) of these intracellular lectins exhibit structural similarities with those of the extracellular lectins such as leguminous lectins and galectins. This book focuses on sugar recognition events in the early secretory pathway and in the ubiquitin/proteasome-mediated degradation pathway. This book discusses the structural and molecular basis for the mechanisms underlying the quality control of glycoprotsins through the interplay of proteins possessing homologous CRDs in cells. (Imprint: Nova)