Sophisticated Modes of Sugar Recognition by Intracellular Lectins Involved in Quality Control of Glycoproteins

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Yukiko Kamiya, Daiki Kamiya, Reiko Urade, Tadashi Suzuki and Koichi Kato
National Institutes of Natural Sciences, Japan, and others

Series: Cell Biology Research Progress
BISAC: SCI017000

Recent advances in molecular and structural glycobiology have shown that a variety of lectins recognize partially trimmed intermediates of the high-mannose-type oligosaccharides and thereby determine the fates of their carrier proteins in cells. The carbohydrate recognition domains (CRDs) of these intracellular lectins exhibit structural similarities with those of the extracellular lectins such as leguminous lectins and galectins. This book focuses on sugar recognition events in the early secretory pathway and in the ubiquitin/proteasome-mediated degradation pathway. This book discusses the structural and molecular basis for the mechanisms underlying the quality control of glycoprotsins through the interplay of proteins possessing homologous CRDs in cells. (Imprint: Nova)

 

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ABSTRACT

INTRODUCTION

PROCESSING OF N-GLYCANS IN CELLS

L-TYPE LECTINS IN THE EARLY SECRETORY PATHWAY

SUGAR RECOGNITION MODES IN THE UBIQUITIN-PROTEASOME PATHWAY

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

INDEX

 

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