Sophisticated Modes of Sugar Recognition by Intracellular Lectins Involved in Quality Control of Glycoproteins
Yukiko Kamiya, Daiki Kamiya, Reiko Urade, Tadashi Suzuki and Koichi Kato
National Institutes of Natural Sciences, Japan, and others
Series: Cell Biology Research Progress
BISAC: SCI017000
Details
Recent advances in molecular and structural glycobiology have shown that a variety of lectins recognize partially trimmed intermediates of the high-mannose-type oligosaccharides and thereby determine the fates of their carrier proteins in cells. The carbohydrate recognition domains (CRDs) of these intracellular lectins exhibit structural similarities with those of the extracellular lectins such as leguminous lectins and galectins. This book focuses on sugar recognition events in the early secretory pathway and in the ubiquitin/proteasome-mediated degradation pathway. This book discusses the structural and molecular basis for the mechanisms underlying the quality control of glycoprotsins through the interplay of proteins possessing homologous CRDs in cells. (Imprint: Nova)
ABSTRACT
INTRODUCTION
PROCESSING OF N-GLYCANS IN CELLS
L-TYPE LECTINS IN THE EARLY SECRETORY PATHWAY
SUGAR RECOGNITION MODES IN THE UBIQUITIN-PROTEASOME PATHWAY
CONCLUSION
ACKNOWLEDGMENTS
REFERENCES
INDEX
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