Snake Venoms and Envenomation: Modern Trends and Future Prospects


Yuri N. Utkin, PhD (Editor)
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Arcadius V. Krivoshein, PhD (Editor)
Albany College of Pharmacy & Health Sciences, Albany, NY

Series: Medicine and Biology Research Developments
BISAC: NAT028000

Snake bites are a major health concern, especially in tropical countries. Understanding the pathology of envenomation and chemical composition of snake venoms is important in the development of medical countermeasures (including, but not limited to, antivenoms). Furthermore, snake venoms can be considered natural “combinatorial libraries” of proteins and peptides. Thus, it is not surprising that components of snake venom have been found extensively useful in biomedical research as well as clinical use for treating diseases as diverse as cancer and muscle pain.

In this book, well-known scientists from the Americas, Asia, and Europe discuss recent trends and outlooks in regards to snake venom research. A distinctively broader coverage of the subject is given, with topics ranging from protein biochemistry to pathology.

Several chapters highlight protein biochemistry and enzymology of snake venoms, immune response to envenomation and antivenoms, production and use of snake venom components as antigens for antivenom preparation, and the therapeutic value of snake venom components in the treatment of various diseases.

A comprehensive and authoritative monograph, this book will be equally interesting to both established researchers and graduate students interested in toxinology and pathology of envenomation. (Imprint: Nova)


Table of Contents

Table of Contents


Section One: General Aspects

Chapter 1. Snakes: Diversity, Epidemiology and Envenomation
Priscila Hess Lopes, Carla Cristina Squaiella-Baptistão, Giselle Pidde Queiroz, Denise V. Tambourgi (Immunochemistry Laboratory, Butantan Institute, São Paulo, SP, Brazil)

Chapter 2. Venoms from “Non-Venomous” Snakes: Rear-Fanged Snake Venoms as Sources of Novel Compounds
Stephen P. Mackessy, Anthony J. Saviola (University of Northern Colorado, School of Biological Sciences, Greeley, Colorado, USA, and others)

Chapter 3. Venom Production in the 21st Century
Kristen L Wiley, James R Harrison (Kentucky Reptile Zoo, Slade, KY, USA)

Section Two: Clinical and Pathophysiological Aspects

Chapter 4. Extending the use of Snake Venoms to Therapeutics
Paul Reid (Celtic Biotech Inc, West Des Moines, IA, USA)

Chapter 5. Pathophysiological Significance and Therapeutic Implications of Russell’s Viper Venom Proteins and Peptides affecting Blood Coagulation
Rupamoni Thakur and Ashis K. Mukherjee (Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, Assam, India, and others)

Chapter 6. Venom Peptide Antagonists of the Nicotinic Acetylcholine Receptor do not Prevent Fatal Encephalitis in the Hamster Model of Rabies
Laurence N. Raymond, Paul F. Reid, Boonlert Lumlertdacha, Felix R. Jackson, Richard Franka (Receptopharm, Inc., Plantation, FL, USA, and others)

Section Three: Immunological and Immunochemical Aspects

Chapter 7. Immune Response Triggered by Snake Venoms: Impact of Venom Compounds on the Envenomation Process
Carla Cristina Squaiella-Baptistão, Giselle Pidde Queiroz, Priscila Hess Lopes, Denise V. Tambourgi (Immunochemistry Laboratory, Butantan Institute, São Paulo, SP, Brazil)

Chapter 8. Antivenoms
Milind V. Khadilkar (Premium Serums & Vaccines Pvt.Ltd., Maharashtra, India)

Section Four: Molecular and Cellular Aspects

Chapter 9. Evolution, Structural Features, and Biochemical Diversity of Snake Venom Serine Proteinases
Monika A.Coronado, Raphael J. Eberle, Fábio R. de Moraes, Jorge H. Fernandez, E.P. Gomes, A. Lira, Raghuvir K. Arni (Multiuser Center for Biomolecular Innovation, Department of Physics, IBILCE/UNESP, São Jose do Rio Preto-SP, Brazil, and others)

Chapter 10. Cytotoxicity of Snake Venoms and Toxins: Mechanisms and Applications
Nget Hong Tan, Choo Hock Tan (Department of Molecular Medicine; bDepartment of Pharmacology, Faculty of Medicine, Univerity of Malaya, Kuala Lumpur, Malaysia)

Chapter 11. Purine – a “Multitoxin” Release Related Enzymes of Snake Venom in Envenomation: An Overview
Bhadrapura L. Dhananjaya (Toxinology/Toxicology and Drug Discovery Unit, Center for Emerging Technologies, Jain Global Campus, Jain University, Kanakapura Taluk, Ramanagara, Karnataka, India)

Commentary: The Promise of Snake Genomics
Michael K. Richardson and R. Manjunartha Kini (Institute of Biology, University of Leiden, The Netherlands, and others)



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