Skin Pigmentation: Genetics, Geographic Variation and Disorders


John B. Smith (Editor)
Mary B. Haworth (Editor)

Series: Dermatology – Laboratory and Clinical Research

In this book, the authors discuss the genetics, geographic variation and disorders associated with skin pigmentation. Topics include the melanocortin-1 receptor as a key melanoma risk determinant and a critical regulator of the UV DNA damage repair response; three major signaling pathways involved in the establishment of mammalian skin and hair coloration via the regulation of tyrosinase activity; multiple genes and diverse hierarchical pathways that affect human pigmentation; acquired skin pigmenation; the pro-opiomelanocortin (POMC) and melanocortin systems in the regulation of human skin pigmentation; and an overview on the melanocyte precursor migration from neural crest. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


The Melanocortin-1 Receptor: A Key Melanoma Risk Determinant and a Critical Regulator of the UV DNA Damage Repair Response
(Stuart G. Jarrett, Alexandra Amaro-Ortiz, Jason Tucker, John D’Orazio, University of Kentucky College of Medicine, The Markey Cancer Center, The Graduate Center for Toxicology and the Departments of Pediatrics and of Molecular and Biomedical Pharmacology, Lexington, KY, USA)

MC1R, EDNRB, and Kit Signaling in Pigment Regulation and Related Disorders
(Javier Pino, Lidia Kos, Department of Biological Sciences, Florida International University, Miami, FL, USA)
<a href=”” target=”_blank” rel=”noopener”>Free Download Available</a>

Multiple Genes and Diverse Hierarchical Pathways Affect Human Pigmentation
(C. Ganesh, Anita Damodaran, Martin R. Green, Sheila Rocha, Nicole Pauloski, Shilpa Vora, Unilever R&D Bangalore, India, and others)
<a href=”” target=”_blank” rel=”noopener”>Free Download Available</a>

Acquired Skin Pigmentation
(Hideo Nakayama, Nakayama Dermatology Clinic, Kami-Ohsaki Shinagawa-ku, Tokyo, Japan)

The Pro-Opiomelanocortin (POMC) and Melanocortin System in Regulation of Human Skin Pigmentation
(Han-En Tsai, Elsa C. Chan, Gregory J. Dusting, Guei-Sheung Liu, Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan, and others)

Overview on the Melanocyte Precursor Migration from the Neural Crest
(Toyoko Akiyama, Ai Shinomiya, Department of Biology, Keio University, Hiyoshi, Kohoku-ku, Yokohama, Japan)


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