Sjögren’s syndrome is a multisystem autoimmune disorder caused by lymphocytic infiltration of the exocrine glands and extraglandular organ systems associated with B cell overactivation and the production of autoantibodies. Sjögren Syndrome: Causes, Diagnosis and Treatment provides a comprehensive overview of primary Sjögren syndrome with emphasis on its clinical presentation.
Several tests are currently available to assess glandular involvement and to establish an accurate diagnosis. In 2016, the new American College of Rheumatology/European League Against Rheumatism developed the classification criteria for primary Sjögren syndrome.
The association of polymorphic marker rs2228262 in THBS1 gene with the risk of developing dry eye syndrom with underlying Sjögren syndrome is also explored. Data was obtained through confocal microscopy which suggests that this polymorphic marker is responsible for the high probability of lesions of corneal nerve fibers in cases of Sjögren syndrome, even if there are no clinical and functional signs dry eye syndrome.
(Imprint: Nova Medicine and Health)