Sjögren Syndrome: Causes, Diagnosis and Treatment

Nicolas Achin (Editor)

Series: New Developments in Medical Research
BISAC: MED022000

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Sjögren’s syndrome is a multisystem autoimmune disorder caused by lymphocytic infiltration of the exocrine glands and extraglandular organ systems associated with B cell overactivation and the production of autoantibodies. Sjögren Syndrome: Causes, Diagnosis and Treatment provides a comprehensive overview of primary Sjögren syndrome with emphasis on its clinical presentation.

Several tests are currently available to assess glandular involvement and to establish an accurate diagnosis. In 2016, the new American College of Rheumatology/European League Against Rheumatism developed the classification criteria for primary Sjögren syndrome.

The association of polymorphic marker rs2228262 in THBS1 gene with the risk of developing dry eye syndrom with underlying Sjögren syndrome is also explored. Data was obtained through confocal microscopy which suggests that this polymorphic marker is responsible for the high probability of lesions of corneal nerve fibers in cases of Sjögren syndrome, even if there are no clinical and functional signs dry eye syndrome.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Sjögren Syndrome: An Update on Clinical Manifestations and Classification Criteria
(M. Slouma, S. Rahmouni and I. Gharsallah, Department of internal medicine, Military Hospital, Tunis El Manar University, Tunisia)

Chapter 2. Diagnosis of Sjögren Syndrome
(M. Slouma, S. Rahmouni and R. Dhahri, Department of internal medicine, Military Hospital, Tunis El Manar University, Tunisia)

Chapter 3. Studying the Role of Polymorphic Markers rs1478604, rs2292305, rs2228262 in THBS1 Gene in Damaging Corneal Nerve Fibers in Autoimmune Dry Eye Syndrome
(T. N. Safonova, Z. V. Surnina, G. V. Zaitseva, V. I. Loginov and A. M. Burdenny, Research Institute of Eye Diseases, Moscow, Russia)

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