Simvastatin Delivery: Challenges and Opportunities

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Alberto A.C.C. Pais, PhD (Editor)
Department of Chemistry, University of Coimbra, Rua Larga, Coimbra, Portugal

João J.S. Sousa, PhD (Editor)
Department of Chemistry, University of Coimbra, Rua Larga, Coimbra, Portugal

Carla Vitorino, PhD (Editor)
University of Coimbra, Rua Larga, Coimbra, Portugal

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

This book presents an overview of recent developments for an “old drug”, simvastatin. It belongs to the class of statins, the most commonly prescribed drugs for the treatment of dyslipidemia or related diseases, being considered of superior effectiveness for that purpose. Now, millions of patients benefit from the use of simvastatin in preventing coronary heart disease.

Simvastatin has been recently identified as a multifaceted drug, addressing different physiological and pathological conditions, thus extending beyond the conventional cholesterol-dependent mechanisms. It has triggered the development of new strategies in order to promote the respective delivery through novel routes of administration.

In this book, a comprehensive selection of topics is presented, encompassing aspects that firstly include chemical synthesis and pharmacology.

In a second part, several delivery systems for new therapeutic areas are explored. These comprise nanoemulsions administered through the parenteral route, nanostructured lipid carriers for transdermal delivery and supramolecular systems for a local application. Cancer therapy and bone regeneration are some of the therapeutic targets addressed along with the classical treatment of hypercholesterolemia, now in drug combination therapies.

This book benefits from the participation of recognized experts from different areas. These include researchers from pharmaceutical technology, pharmacology and synthetic chemistry. (Imprint: Nova Biomedical)

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Table of Contents

Preface

Synthesis of Simvastatin: Historical Perspective and New Developments
(Marta Pineiro, Department of Chemistry, University of Coimbra, Rua Larga, Coimbra, Portugal)

The Pharmacology of Simvastatin: From the Mechanism of Action to New Therapeutic Applications
(Ana Fortuna, Gilberto Alves, Amílcar Falcão, Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal, and others)

Crossing the Skin Barrier: A Development Strategy
(Carla Vitorino, António Almeida, João José Sousa, Alberto Pais, Pharmacometrics Group of the Centre for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal, and others)

In situ Administration: Simvastatin in Bone Regeneration
(Susana Simões, Francisco Veiga, Angel Concheiro, Carmen Alvarez-Lorenzo, Faculty of Pharmacy and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, and others)

The Parenteral Route: Simvastatin in Cancer Treatment
(Alaadin Alayoubi, Ahmed Abu Fayyad, Turki Al Hagbani, Sami Nazzal, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA, and others)

Index

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