Sickle Cell Disease: Genetics, Management and Prognosis


Marilyn E. Lewis (Editor)

Series: Recent Advances in Hematology Research
BISAC: MED038000

Sickle cell disease (SCD) is a genetic disorder caused by an abnormality of hemoglobin. The disease is characterized by a chronic hemolytic anemia. The search for affordable and accessible medicines mainly from plants and having various modes of actions for managing SCD is a priority in Africa where the disease is endemic.

The first chapter in this book reviews children with Sickle Cell Disease (SCD). The authors also present their research that shows that clinically, children with SCD behave differently regarding their genetics. The second chapter gives an overview of the current progress in research in calcium handling in red blood cells of sickle cell disease patients, followed by an outlook into the potential use of blockers of the cation channels for therapy of SCD patients. The third chapter reviews and validates the pharmacological relevance of “Gardenia ternifolia” and sustains the use of this herbal medicine in the management of SCD in traditional medical systems.

The fourth chapter reviews the search and the development of antisickling herbal drugs in Africa, where Sickle cell disease (SCD) is an endemic. The last chapter reviews SCD and its impact on sexual functioning as well as relationship dynamics. Conclusions support the importance of social support and its far-reaching impact into the coping mechanisms of patients with chronic illness as well as quality of life.
(Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter One
Sickle Cell Disease-Genetics and Sleep
(Helena Cristina Loureiro, Alexandra Dias, Maria Inês Mascarenhas, Teresa Ferreira, Pediatric Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal, and others)

Chapter Two
Calcium Handling in Red Blood Cells of Sickle Cell Disease Patients
(Anna Bogdanova, Asya Makhro, Lars Kaestner, Institute of Veterinary Physiology and the Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland, and others)

Chapter Three
Antisickling and Radical Scavenging Activities of Anthocyanin Extracts from the Leaves of Gardenia ternifolia subsp. jovis-tonantis (Welw.) Verdc. (Rubiaceae)
(P. T. Mpiana, K. N. Ngbolua, D. S. T. Tshibangu, D. T. Mwanangombo and P. V. Tsalu, Department of Chemistry, Faculty of Science, DR. Congo, and others)

Chapter Four
Bioactivity of Medicinal Plants Traditionally used for the Management of Sickle Cell Disease in Democratic Republic of the Congo: State of the Art and Future Directions
(K. N. Ngbolua, P. T. Mpiana, D. S. T. Tshibangu, and B. Z. Gbolo, Department of Biology, Faculty of Science, University of Kinshasa, Democratic Republic of the Congo, and others)

Chapter Five
Pain, Sexual Activity and Partner Support in Jamaicans with Sickle Cell Disease
(Kai A.D Morgan, Naila Smith, Roger, C. Gibson, Wendel D. Abel, Monika Parshad-Asnani, Marvin Reid, Keisha N. O’Garo, Christopher L. Edwards, Department of Community Health & Psychiatry, University of the West Indies, Mona Campus, Kingston, Jamaica W. I., and others)


Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!