Serotonin: Biosynthesis, Regulation and Health Implications


Frank Scott Hall (Editor)
Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA

Series: Neuroscience Research Progress
BISAC: MED057000

Serotonin has long been known to have important roles in many systems of the body that impact human health and disease. In this volume a number of leading researchers in the serotonin field discuss the functions of serotonin in the nervous system, and other bodily systems, based on accumulating knowledge from both clinical and preclinical studies. Preclinical studies across a broad range of vertebrate and non-vertebrate model organisms are considered that implicate a deep evolutionary history for serotonin function that substantiate the validity of these model systems. Although the importance of serotonin in many areas of medical and biological research has been appreciated for some time, the importance of serotonin in many areas of research is still emerging. This volume considers many of these long-standing areas of study in serotonin research, including well-established conditions in which serotonin is known to have important roles, including anxiety, depression and alcoholism, but for which new information has continued to emerge – in addition to newer areas of study in which the importance of serotonin is just coming to be appreciated. Deepening understanding of these functions of serotonin systems will provide novel avenues of exploration for the development of therapeutic approaches to treat the medical conditions in which serotonin has been implicated. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1. Serotonin in Insects: Distribution, Biosynthesis, Uptake, Inactivation, Receptors, Functions and Implications for Human Health
(Wolfgang Blenau, Markus Thamm and Arnd Baumann, Institut für Bienenkunde, Goethe-Universität Frankfurt am Main, Oberursel, Germany and others)

Chapter 2. Serotonergic Modulation of Aggression
(Jens Herberholz, Department of Psychology, University of Maryland, College Park, MD, USA)

Chapter 3. The Serotonergic System of Zebrafish: Genomics, Neuroanatomy and Neuropharmacology
(Caio Maximino, Monica Gomes Lima, Juliana Araujo, Karen Renata Matos Oliveira, Anderson Manoel Herculano, Adam Michael Stewart, Evan J. Kyzar, Jonathan Cachat and Allan V. Kalueff, Laboratory of Neuroendocrinology, Institute of Biological Sciences, Federal University do Para, Belem, Brazil and others)

Chapter 4. A Nonhuman Primate Model of Serotonin-Mediated Violence and Antisocial Behavior – A Decade-and-a-Half Update
(Whitney F. Espinel and J. Dee Higley, Department of Psychology, Brigham Young University, Provo, UT, USA)

Chapter 5. Cellular Physiology of the DRN: Implications for Anxiety and Depression
(Rani K. Vasudeva, Lynn G. Kirby, Barry D. Waterhouse, Temple University School of Medicine, Philadelphia, PA, USA and others)

Chapter 6. The Differential Involvement of the Serotonergic System in Depression and Antidepressant Treatment of Males and Females
(Christina Dalla, Nikolaos Kokras, Pothitos M. Pitychoutiz, Zeta Papadopoulou-Daifoti and Jocelien D.A. Olivier, Department of Pharmacology, Medical School, University of Athens, Athens, Greece and others)

Chapter 7. Developmental Influences of 5-HT on Depression: Roles of BDNF, Stress, and Inflammatory Processes
(Andrea Wieck, Heather C. Brenhouse and Susan L. Andersen, McLean Hospital, Harvard Medical School, Boston, MA, USA and others)

Chapter 8. The Role of Serotonin in the Neurodevelopmental Consequences of Social Isolation: Undue Emphasis on Stress
(F. Scott Hall and Maria T. G. Perona, Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltmore, MD, USA)

Chapter 9. The Role of Serotonin in the Effects of Psychostimulant Drugs: Behavioral Studies of Addiction- and Abuse-Related Phenotypes in Knockout Mice
(Yuki Moriya, F. Scott Hall and Ichiro Sora, Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Miyagi, Japan and others)

Chapter 10. Serotonin (5-HT)<sub>2C</sub> Receptors and Drug Abuse
(Andrew C. McCreary, Umberto Spampinato, Edmund Przegalinski and Malgorzata Filip, Brains On-Line, Groningen, the Netherlands and others)

Chapter 11. Contribution of Serotonin 5-HT<sub>2</sub> Receptor to Ethanol-induced Sensitization and Ethanol Consumption in Mice
(Roseli Boerngen-Lacerda, Yara Jamal, Diego Correia and Francine Oliveira Goeldner, Department of Pharmacology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil)

Chapter 12. Cocaine-induced Conditioned Taste Aversions: Role of Monoamine Reuptake Inhibition
(Katherine M. Serafine and Anthony L. Riley, Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC, USA)

Chapter 13. Serotonin Syndrome- and Psychostimulant Drug-induced Hyperthermia and their Treatment
(Katsutoshi Shioda, Makiko Kasai and Koichi Nisijima, Department of Psychiatry, Jichi Medical University, Shimotsuke, Tochigi-Ken, Japan)

Chapter 14. Psychobiological Studies showing the Serotonin Involvement in Cognition-related Behavioral Performance
(Ignacio Gonzalez-Burgos and Alfredo Feria-Velasco, Lab. Psicobiología, Div. Neurociencias, Ctr. Inv. Biomed. Occte., IMSS, Guadalajara, Jal. Mexico and others)
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Chapter 15. Contribution of the Serotonin 5-HT<sub>2B</sub> Receptors to Health and Disease
(Luc Maroteaux, Laurent Monassier and Jean-Marie Launay, Institut du Fer à Moulin, Paris, France and others)

Chapter 16. The Role of Serotonin in the Pathophysiology of Fibromyalgia
(Mario D. Cordero and Elisabet Alcocer-Gomez, Pablo de Olavide and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Sevilla, Spain and others)

Chapter 17. Role of Serotonin in Melanogenesis in the Skin
(Chang Hoon Lee, College of Pharmacy, Dongguk University, Seoul, Korea)


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