Serotonin and Dopamine Receptors: Functions, Synthesis and Health Effects

Monica Munoz and Marshall Mckinney (Editors)

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

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In this compilation, the authors begin with a review of the mechanisms of synthesis and secretion, cellular effects and the involvement of serotonin (5-HT) in physiological and behavioral functions horses. In addition, the pathological conditions in which 5-HT is involved at the level of equine clinics are studied. Following this, the capabilities and limitations of PET imaging research on non-human primates are discussed for translation to brain DA research on humans, as well as therapeutic drug development for neurodegenerative diseases. This book also examines the etiology of autism spectrum disorder (ASD). The authors present available data contributing to the appreciation of a serotonergic dysfunction in ASD, as well as discuss new avenues to reveal the pathophysiology of this multifactorial disorder. Next, they review the historical and current evidence that links neurotransmitters with hemopoeitic stem cell mobilization, trafficking, and specially emphasize the role of serotonin in erythropoiesis. Potential actionable myelodysplastic and leukemic pathways are described and investigated.

Preface

Chapter 1. The Physiopathological Features of Serotonin in Horses
(Satué, K., Gardon, J.C., and Marcilla, M., Department of Animal Medicine and Surgery, Cardenal Herrera University, Spain, and others)

Chapter 2. PET Imaging of Dopaminergic Function in Non-Human Primates
(Hideo Tsukada, Central Research Laboratory, Hamamatsu Photonics K.K., Hirakuchi, Hamakita, Hamamatsu, Shizuoka, Japan)

Chapter 3. The Serotonin System in Autism Spectrum Disorder
(Denis Sarrouilhe, Marc Mesnil, and Catherine Dejean, Laboratoire de Physiologie Humaine, Faculté de Médecine et Pharmacie, Université de Poitiers, Poitiers, Cedex 9, France, and others)

Chapter 4. Serotonin in Normal and Malignant Hematopoiesis
(Hussein Hamad, MD, Patrick Song and Gustavo Rivero, MD, Department of Medicine, Section of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA, and others)

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