Sepsis: Diagnosis, Management and Health Outcomes


Nancy Khardori (Editor)
Department of Microbiology and Molecular Cell Biology, Eastern Virginia medical School, Norfolk Virginia

Series: Allergies and Infectious Diseases
BISAC: MED022090

The book discusses multiple aspects of sepsis syndrome seen in all age groups of patients and by all specialties in medicine. The syndrome is the aftermath of the dissemination of an infectious process into and through the blood stream. This allows the bacteria, bacterial products and cytokines to reach multiple organs, resulting in their dysfunction. In spite of the advances in supportive care and antibiotic therapy, the outcome of sepsis has not changed significantly.

The inadequacies in the current diagnostic modalities and conflicting inconclusive results of investigations on novel treatments have contributed significantly to the lack of progress in the management of sepsis. Antibiotic overuse in and outside the intensive care unit driven by the lack of microbiological data and definitive diagnosis lends to the creation and transmission of antibiotic resistant bacteria, which has added to the challenges and poor outcomes of sepsis syndrome.

The nine chapters in this book are authored by experts in various aspects of sepsis from North America, South America, Europe and Asia. State of the art information is provided in the areas of pathogenesis, epidemiology, diagnosis and management of sepsis. Each chapter has a contribution on the role of various evidence-based preventive strategies to reduce the incidence and subsequent poor outcomes of sepsis syndrome. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Sepsis: Molecular Events, Interventions and Novel Approaches
(Markus Bosmann, Peter A. Ward, Center for Thrombosis and Hemostasis, University Medical Center, Mainz, Germany, and others)

Myocardial Dysfunction in Sepsis: Role of Apelin, A Novel Promising Molecule
(Robert Dumaine, Michaël Biet, David Coquerel, Olivier Lesur, Dept de Médecine (Soins Intensifs Médicaux) and Dept de Physiologie-Biophysique, Université de Sherbrooke, Québec, Canada)

Acute Kidney Injury in Sepsis
(Marcelo Rodrigues Bacci, Assistant Professor- General Practice Department-Faculdade de Medicina do ABC (ABC Medical School)- São Paulo- Brazil)

Prevention of Hospital–Acquired Infection with Focus on Sepsis in Neonatal Intensive Care Units: Use of Quality Improvement Efforts
(Adolf Valls-i-Soler, Marisela Madrid, Agueda Azpeitia, Elena Santesteban, Neonatal Intensive and Neonatal Epidemiology Units, Cruces University Hospital, University of the Basque Country, Bilbao, Spain)

Sepsis in Adults: Risk Factors, Diagnosis, Management and Health Outcomes
(Suma S. Rao, A.S.M.M. Akther, Nancy Khardori, American Board of Internal Medicine and Infectious Diseases (USA) Consultant, Infectious Diseases, Changi General Hospital, Singapore, and others)

Prevention of Hospital–Acquired Infections in Adults: Focus on “Surviving Sepsis Campaign”
(Vidya Sundareshan, Rajagopal Sreedhar, Nancy Khardori, Assistant professor , Division of Infectious Diseases , Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield , Illinois, US and others)

Medical Device Infections and Sepsis
(Lokesh Shahani, Rabih O. Darouiche, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, US and others)

Molecular Diagnostics and Inflammatory Biomarkers in Diagnosis of Sepsis
(Chand Wattal, Reena Raveendran, Dept of Clinical Microbiology & Immunology, GRIPMER, Sir Ganga Ram Hospital, New Delhi, India)

Intricacies of Hyperglycemia and Disordered Glucose Metabolism in Sepsis
(Jagdeesh Ullal, Valeria Bohrt-Terceros, Romesh Khardori, Assistant Professor of Medicine/Endocrinology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, US and others)


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