$0.00
Moonseong Heo and Mimi Y. Kim
Albert Einstein College of Medicine, Bronx, New York, USA
Series: Mathematics Research Developments
BISAC: MAT000000
Experimental clinical trial settings are now often extended to community entities beyond academic research centers. In such settings, a cluster randomized clinical trial (cluster-RCT) design can be useful to rigorously test the effectiveness of a new intervention. At the design stage of the cluster-RCT, it is essential to estimate a sample size sufficient for adequate statistical power to evaluate the different intervention effects. However, the sample size estimation must account for the multilevel data structure that is necessitated by the nature of the cluster-RCT design. This book reviews a three-level data structure and summarizes sample size approaches for testing intervention effects within a unified framework of mixed-effects linear models. (Imprint: Nova)
Table of Contents
ABSTRACT
1. INTRODUCTION
2. PRINCIPLES OF STATISTICAL POWER CALCULATION
3. MIXED EFFECTS LINEAR MODEL FOR THREE- LEVEL DATA
4 HYPOTHESIS (I): OVERALL MAIN INTERVENTION EFFECTS
5. HYPOTHESIS (II): TIME-BY-INTERACTION EFFECTS
6. HYPOTHESIS (III): INTERVENTION EFFECTS AT THE END OF TRIAL
7. SUMMARY AND APPLICATIONS
8. DISCUSSION
REFERENCES
INDEX
We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!
