Salmonella Pathogenesis and Progression in the Development of Human and Veterinary Non-Typhoidal Salmonella Vaccines against Human Salmonellosis

Rahul M. Nandre
John Hwa Lee
College of Veterinary Medicine, Chonbuk National University, Korea

Series: Veterinary Science and Medicine
BISAC: MED089000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The important foodborne zoonotic pathogen non-typhoidal Salmonella cause gastroenteritis, bacteremia and focal infection in humans. Salmonella evades the host’s immune system through the coordinated expression of complex arrays of virulence associated-genes. The dynamics of host-pathogen Salmonella enterica interaction and infection might enhance the development of novel targeted preventative measures and drug regimens. However, widespread usage of antibiotics has led to the emergence of multiple antibiotic-resistant Salmonella. To avoid this problem, effective vaccines are developed to control non-typhoidal Salmonella zoonotic infections.

An understanding of how Salmonella enterica spreads and survives in tissues has very important implications for targeting intracellular Salmonella with vaccine-induced immune responses. Application of advanced knowledge and scientific methods in the development of vaccines could diminish the non-typhoidal Salmonella disease burden globally. Currently, the oral live attenuated vaccines showed an efficient protection against non-typhoidal Salmonella zoonotic infection. However, inactivated or sub-unit vaccines are considered to be the safest over live vaccines. Ultimately, this review explores the molecular basis of non-typhoidal Salmonella pathogenesis. In addition to pathogenesis, recent advances in generation of Salmonella vaccines are also emphasized. This review also gives a deep insight into the future development of Salmonella vaccines with different innovations. (Imprint: Nova)

Introduction

Chapter 1 - Clinical Features of Non-Typhoidal Salmonella (NTS) (pp. 1-2)

Chapter 2 - Salmonella Pathogenicity (pp. 3-16)

Chapter 3 - Obstacles in the Control Measures and Vaccination to Prevent Salmonellosis (pp. 17-18)

Chapter 4 - Current Progress in NTS Vaccine Development (pp. 19-28)

Chapter 5 - Future Prospectus for the Development of Non-Typhoidal Vaccines (pp. 29-30)

Conclusion

References

About the Authors

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