S100B: Serum Detection, Functions and Clinical Significance

Rafael Ruiz (Editor)

Series: Neuroscience Research Progress



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Several studies have shown the presence of increased values of S100B in samples from patients with degenerative central nervous system (CNS) disorders, such as amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease. The first two chapters review the main findings and clinical significance of S100B detection serum and/or cerebrospinal fluid from patients suffering from such neurogenerative disorders.

In the third chapter of the book, the authors present an updated view of the interrelation between S100B, glia, neuroinflammation, and depression, as well as their experience in stroke, where they encountered increased serum S100B levels in patients with more severe post-stroke depressive symptoms and proposed its possible utility as a blood marker for the prediction of post-stroke depression.
(Imprint: Nova)


Chapter 1
Clinical Significance of S100B Protein in Neurological Diseases
9Sergio González-García, Alina González-Quevedo, Marisol Peña-Sánchez, Anay Cordero-Eiriz, Zenaida Hernández-Díaz, Caridad Menéndez-Saínz, Marianela Arteche-Prior, Otman Fernández-Concepción and Rebeca Fernández-Carriera, Institute of Neurology and Neurosurgery, Havana, Cuba)

Chapter 2
S100B as a Candidate Biomarker and Therapeutic Target in Neurodegenerative Disorders
(Adelaide Fernandes, Ana Rita Vaz, Dora Brites, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, Lisbon, Portugal, and others)

Chapter 3
Calcium-Binding Protein S100B, Inflammation and Glia in the Development of Depression
(Alina González-Quevedo, Sergio González-García, Zenaida Hernández-Díaz, Otman Fernández-Concepción, Marisol Peña-Sánchez, Caridad Menéndez-Saínz, Marianela Arteche-Prior, Alejandro Pando-Cabrera and Rebeca Fernández Carriera, Institute of Neurology and Neurosurgery. Havana, Cuba)


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