Retinoic Acid: Functions, Regulation and Health Effects

Jonah Cope and Leida Segura (Editors)

Series: Chemistry Research and Applications
BISAC: SCI013020

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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In this book, the authors examine retinoic acid and how it plays important role in a wide range of biological processes including proliferation and differentiation especially epithelial tissues. The mechanism of actions of retinoic acid in human keratinocytes and dermal fibroblasts are reviewed, as well as its clinical use in dermatological treatments. Next, the control of gene expression in hepatocytes is discussed. Retinoic acids (RA), including all-trans and 9-cis retinoic acids, are the bioactive components that bind and activate their cognate nuclear receptors to regulate target genes. The authors conclude by testing whether increased progesterone can bias sex ratios in the domestic hen. They determine that there is not a significant shift of the sex ratio after these preliminary experiments. These results suggest the existence of progesterone as additional inducer of meiosis in embryonic germ cell and independently of RA signaling in the chicken.

Preface

Chapter 1. All-Trans Retinoic Acid: Functions, Regulations and Health Benefits
(Angkana Wichit, Ph.D., Cosmetic Science, School of Pharmacetical Sciences, University of Phayao, Thailand and Neti Waranuch, Ph.D., Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand)

Chapter 2. How Retinoic Acid Regulates Gene Expression in Developing Liver: The Hepatoma Alpha-Fetoprotein Gene as a Model
(Ruiqin Jiao and Jen-Fu Chiu, Department of Biochemistry, Nanjing University, Nanjing, China, and others)

Chapter 3. Retinoic Acid, Steroids and Bird Meiosis
(Trukhina A.V., Lukina N.A., Nekrasova A.A., Smirnov A.F., Department of Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia)

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