Retinoblastoma: Diagnosis to Management

$230.00

Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H V Desai Eye Hospital, Maharashtra, India

Series: Eye and Vision Research Developments
BISAC: MED063000; MED062040
DOI: https://doi.org/10.52305/QXSH5126

Retinoblastoma is a unique malignancy. Unlike most of the solid tumors of the human body, retinoblastoma tumors can be directly visualized and examined. In-depth understanding of the clinical features, indications for appropriate imaging and protocol-based treatment for retinoblastoma have proven to be valuable in managing this intraocular malignancy. The treatment options for retinoblastoma have evolved significantly and now strive for better globe and visual function salvage. There is, however, an undeniable disparity in presentation, accessibility of care, patient compliance and outcomes seen between the developed world and developing or under-developed parts of the world. This book has been designed keeping in mind the current world-wide scenario on retinoblastoma. Experienced contributors from different parts of the world have been invited to address the important aspects of retinoblastoma, namely epidemiology, tumor biology and genetics, clinical diagnosis, treatment options and recent advances in research. Each chapter is aimed at providing evidence-based knowledge via text and illustrations.

Table of Contents

Preface

Chapter 1. Understanding the Global Burden of Retinoblastoma
Ankit Singh Tomar, MD
Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center, New York, NY, USA

Chapter 2. Tumorigenesis in Retinoblastoma
Puja Maitra1, DNB, MRCS(Ed), Tony D. Kang2 and Vikas Khetan3,*, MS, FRCS
1Medical Research Foundation, Sankara Nethralaya, Chennai, India
2Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA
3Medical Research Foundation, Sankara Nethralaya, Chennai, India

Chapter 3. Genetics of Retinoblastoma – Molecular and Clinical Features
Puja Maitra1, DNB, MRCS (Ed), Russell J. Marchese2 and Vikas Khetan1,*, MD, FRCS
1Medical Research Foundation, Sankara Nethralaya, Chennai, India
2Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA

Chapter 4. Genetic Testing and Counselling in Retinoblastoma
Puja Maitra1, DNB, MRCS(Ed), Bailey Harrison2 and Vikas Khetan1, MD, FRCS
1Medical Research Foundation, Sankara Nethralaya, Chennai, India
2Flaum Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

Chapter 5. Pathology of Retinoblastoma
Kaustubh Mulay
National Reporting Centre for Ophthalmic Pathology (NRCOP), Centre For Sight, Hyderabad, India

Chapter 6. Clinical Manifestations of Retinoblastoma
Sonal P. Yadav, MS, FACS
Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology,
PBMA’s H. V. Desai Eye Hospital, Pune, India

Chapter 7. Differential Diagnosis of Leukocoria
Shivangi Singh1, DNB, Harshita Sharma2, DO, DNB, Nikhil Beke1, MS and Sonal P. Yadav2, MS, FACS
1Department of Retina, Orbit and Ocular Oncology, PBMA’s H V Desai Eye Hospital, Pune, Maharashtra, India
2Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H V Desai Eye Hospital, Pune, Maharashtra, India

Chapter 8. Imaging Techniques in Retinoblastoma
Sonal P. Yadav, MS, FACS
Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology,
PBMA’s H V Desai Eye Hospital, Pune, Maharashtra, India

Chapter 9. OCT, OCTA and FA in Retinoblastoma
Juan Pablo Fernandez1, Ekaterina Semenova1 , Anthony Fam2 and Miguel A. Materin1
1Department of Ophthalmology, Duke University, Durham, NC, USA
2 Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY, USA

Chapter 10. Staging and Grouping of Retinoblastoma
Sonal P. Yadav, MS FACS
Deptartment of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology PBMA’s H. V. Desai Eye Hospital, Pune, India

Chapter 11. Intravenous Chemotherapy for Retinoblastoma
Usha Singh1, MS, Sameeksha Gowravajhala1, MD, Deepak Bansal2, MD, and Sonal P Yadav3, MS FACS
1Department of Ophthalmology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India
2Department of Paediatric Hemato-oncology, Post-graduate Institute of Medical Education and Research, Chandigarh, India
3Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H. V. Desai Eye Hospital, Pune, India

Chapter 12. Intra-Arterial Chemotherapy (IAC) for Retinoblastoma
Sameeksha Gowravajhala1 and Sonal P. Yadav2
1Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H. V. Desai Eye Hospital, Pune, India

Chapter 13. Focal Therapy in Retinoblastoma
Sonal P. Yadav, MS, FACS
Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H. V. Desai Eye Hospital, Pune, India

Chapter 14. Intravitreal Chemotherapy in Retinoblastoma
Ekaterina Semenova1, Juan Pablo Fernandez1, Anthony Fam2, Miguel A. Materin1
1
Ocular Oncology Department, Duke Eye Center, Durham, NC, USA
2Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY, USA

Chapter 15. Plaque Brachytherapy in Retinoblastoma
Divyansh Kailashchandra Mishra1 DO, DNB, FVRS, FAICO, ICO, FGO, PGDM and Mahesh Palanivelu Shanmugam2 MBBS, DO, FRCSEd, PhD, FAICO
1Consultant Department of Vitreo Retina and Ocular Oncology Services, Sankara Eye Hospital, Bangalore, India
2Head of the Department Vitreo Retina and Ocular Oncology Services, Sankara Eye Hospital, Bangalore, India

Chapter 16. External Beam Radiotherapy in Retinoblastoma
Sonal P. Yadav, MS, FACS
Dept of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H. V. Desai Eye Hospital, Pune, India

Chapter 17. Enucleation and Exenteration in Retinoblastoma
Sonal P. Yadav
Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology,
PBMA’s H V Desai Eye Hospital, Pune, Maharashtra, India

Chapter 18. Retinal Detachment and Cataract Surgeries in Retinoblastoma Patients
Pradeep Sagar,1 Sowmya Raveendra Murthy,2 and Mahesh P Shanmugam3
1Department of vitreo-retina, Sankara eye hospital, Shimoga, Karnataka, India
2Department of pediatric ophthalmology, Sankara eye hospital, Bangalore, Karnataka, India
3Department of vitreo-retina and ocular oncology, Sankara eye hospital, Bangalore, Karnataka, India

Chapter 19. Orbital Retinoblastoma
Namita Kumari and Sima Das
Oculoplasty and Ocular Oncology Services, Dr. Shroff’s Charity Eye Hospital, New Delhi, India

Chapter 20. Metastatic Retinoblastoma
Frank Y. Lin1, MD, Patricia Chévez-Barrios1 ,2, MD, and Murali M. Chintagumpala1, MD
1Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX, USA
2Ophthalmic Pathology, Department of Pathology and Genomic Medicine,
Houston Methodist Hospital, Houston, TX, USA

Chapter 21. Visual and Prosthetic Rehabilitation of Retinoblastoma Children
Namita Kumari, MS and Sima Das, MS
Oculoplasty and ocular Oncology Services, Dr Shroff’s Charity Eye Hospital, Daryaganj, New Delhi, India

Chapter 22. Liquid Biopsy for Retinoblastoma: Recent Advances and Future Directions
Shreya Sirivolu1,2, Deborah Im1,2, Mary E. Kim1,2, Liya Xu1,3, PhD, and Jesse L. Berry1,2,4,5, MD
1The Vision Center at Children’s Hospital Los Angeles, Los Angeles, CA, USA
2USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
3Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA
4Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
5The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Chapter 23. Retinoblastoma in the Developed World
Dan S. Gombos, MD, FACS
Professor & Chief, Section of Ophthalmology, Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Clinical Co-Director, The Retinoblastoma Center of Houston, Texas Children’s Hospital, Baylor College of Medicine, Houston Methodist Research Institute, Houston, Texas, USA

Chapter 24. Retinoblastoma in a Developing World
Sonal P. Yadav, MS, FACS
Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, PBMA’s H. V. Desai Eye Hospital, Pune, India

Index