Resveratrol: Sources, Production and Health Benefits

Dominique Delmas (Editor)
University of Burgundy, Inserm Research Center “Lipides, Nutrition, Cancers,” Dijon, France

Series: Biochemistry Research Trends
BISAC: SCI007000

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A wide variety of plant-derived compounds, including polyphenols, are present in the human diet and may protect against vascular diseases, cancers, viral infections, neurodegenerative processes and associated anti-inflammatory effects. Among these bioactive compounds, several human studies revealed that resveratrol, a trans-3,4’,5-trihydroxystilbene, found in various natural products may be one of the main wine micro-components responsible for health benefits. Indeed, this polyphenol possesses a myriad of beneficial effects and can act at multiple levels, such as cellular signaling, enzymatic pathways and gene expression. Many laboratories have studied the molecular and cellular mechanisms of resveratrol in various models to get insight into its mechanisms of action in various disease processes. The increase of resveratrol interest is both reflected by the number of publications in databases, approximately 4,520 in Medline, and by the large number of patents copyrighted by biotechnology companies with new applications in cosmetic fields, central nervous system, food complement, preparations.

To better understand the origins of resveratrol, its cellular and molecular mechanisms in plants and humans, this book on resveratrol has been divided into sections ranging from natural and industrial production to the latest scientific advances and clinical trials through the participation of leading scientists in each area covered in this book.

Section 1 describes the sources and new engineering processes for custom and commercial bioreactors production of resveratrol.

Section 2 is devoted to the common and new methods of resveratrol analysis. The following sections concern the health benefits of resveratrol.

Section 3 shows the anti-oxidant properties of resveratrol in various physiopathological states.

Section 4 focuses on the cardioprotective effects of resveratrol and the improvement of the endothelial function.

Section 5 deals with metabolic disorders and the potential use of resveratrol in the prevention and treatment of obesity and osteoporosis.

Section 6 is dedicated to health benefits of resveratrol against inflammation and associated diseases such as rheumatoid arthritis. The role of new targets such as microRNAs in the biological response of resveratrol is also discussed.

Section 7 describes the anticancer properties of resveratrol through the chemoprevention of various cancers, the modulation of cell cycle, the induction of apoptosis and DNA damages.

Section 8 reviews the potential use of resveratrol in neuroprotection such as neurovascular system and neuroglial plasticity, and in the prevention and treatment of neurodegenerative diseases such Alzheimer’s and Parkinson’s diseases. Besides the prevention of a number of diseases, other aspects such as dietary intake and bioavailability are important for the comprehension of resveratrol mechanisms of action.

In this area, section 9 provides an overview of the metabolism of resveratrol, its pharmacokinetics and the recent advances in resveratrol delivery.

The last part of this book, section 10, is dedicated to the clinical development of resveratrol and to the future development of resveratrol derivatives to provide new pharmacological tools for treatment of various diseases.

We hope that this book may provide a valuable tool for graduate and PhD students in sciences, biology, medicine and pharmacology and for scientist or clinicians working in this field or all the people using this polyphenol. (Imprint: Nova Biomedical )

Preface

Editor

Contributors

Section 1: Source and Production of Resveratrol

Chapter 1. Resveratrol from Vine to Wine
(Marielle Adrian, Mirko De Rosso, Luigi Bavaresco, Benoît Poinssot, Marie-Claire Héloir, UMR 1347 Agroécologie, AgroSup/INRA/uB,
Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, Dijon cedex, France, and others)

Chapter 2. Production of Grapevine Cell Biomass (Vitis vinifera L. Gamay) and Resveratrol in Custom and Commercial Bioreactors using Cyclodextrins and Methyl-Jasmonate Elicitors
(Juan Carlos Vera-Urbina, Susana Sellés-Marchart, María José Martínez-Esteso, María Angeles Pedreño and Roque Bru-Martinez, Department of Agrochemistry and Biochemistry, Faculty of Science, University of Alicante, Alicante, Spain, and others)

Section 2: Analytical Methods of Resveratrol

Chapter 3. Development of Voltammetric Techniques and Sensors for the Determination of Resveratrol
(Adrian Marcelo Granero, Fernando Javier Arévalo, Héctor Fernández, María Alicia Zon, Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, Argentina)
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Chapter 4. Adsorption Properties of Synthetic Determinations of Resveratrol
(Konstantin E. Polunin and Irina A. Polunina, Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia)

Chapter 5. A Fast and High-throughput MEPS/UHPLC-PDA-based Methodology for Separation and Identification of Resveratrol in Wine
(João Gonçalves and José S. Câmara, Centro de Química da Madeira, Centro de Ciências Exactas e da Engenharia da Universidade da Madeira, Campus Universitário da Penteada, Funchal, Portugal)

Section 3: Health Benefits of Resveratrol: Anti-oxidant Properties

Chapter 6. Antioxidant Properties of Resveratrol and Health Protection in Pathophysiological States
(Ramón Rodrigo, David Gil-Becerra and Andrés Miranda-Merchak, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Chile)

Chapter 7. Resveratrol and Oxidative Stress of Ageing
(Qingzhao Ruan and Runsheng Ruan, Royal Free and University College Medical School, University College London, Gower Street, London, and others)

Section 4: Health Benefits of Resveratrol against cardiovascular diseases

Chapter 8. Antioxidant Properties of Resveratrol and its Promising Effects in Cardiovascular Disease
(Dominique Bonnefont-Rousselot, Service de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Paris Cedex, France, and others)

Chapter 9. Molecular Mechanisms on How Resveratrol Enhances Endothelial NO Production
(Huige Li and Ulrich Förstermann, Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Mainz, Germany)

Section 5 : Health Benefits of Resveratrol against Metabolic Disorders

Chapter 10. Basis for Resveratrol’s Potential for Prevention and Treatment of Obesity and Osteoporosis
(Clifton A. Baile, Mary Anne Della-Fera and Srujana Rayalam, Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA, and others)

Chapter 11. Resveratrol and Energy Metabolism
(Marc Pignitter and Veronika Somoza, Department of Nutritional and Physiological Chemistry, University of Vienna, Vienna, Austria)

Section 6: Health Benefits of Resveratrol against inflammation and associated diseases

Chapter 12. Resveratrol, a Potent Agent against Inflammatory and Oxidative Stress-Related Diseases
(Carmen Pinto, Beatriz Rodríguez-Galdón and Pedro Macías, Department of Biochemistry and Molecular Biology. Faculty of Sciences, Extremadura University. Badajoz. Spain)

Chapter 13. Evidence to Support Testing of Resveratrol for Efficacy in Rheumatoid Arthritis
(Paul J. Davis, Ole Vang, Ran Meng, Dana Crawford, Jenn-Haung Lai, Feng-Cheng Liu, Heng-Yuan Tang, Hung-Yun Lin, Ordway Signal Transduction, NY, USA, and others)

Chapter 14. Effects of microRNAs in the Biological Response of Resveratrol
(Malek Kechrid and Partha Mukhopadhyay, Laboratory of Physiologic Studies, NIAAA, National Institute of Health, Bethesda, MD, USA)

Section 7 : Health Benefits of Resveratrol against Cancers

Chapter 15. Can We Prevent Cancer? The Role of Resveratrol in Chemoprevention
(Eduardo Cremonese Filippi-Chiela, Guido Lenz and Lauren Lúcia Zamin, Center of Biotechnology; Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, and others)

Chapter 16. Therapeutic Potential of Resveratrol against Cancers: Focus on Cell Proliferation and Cell Death Pathways
(Dominique Delmas, Virginie Aires, Emeric Limagne, Gérard Lizard, Aziz Hichami, François Ghiringhelli and Norbert Latruffe, Université de Bourgogne, Dijon, France, and others)

Chapter 17. Role of DNA Damage in the Antitumoral Activity of Resveratrol
(Emiliano Basso, Stefano Leone and Renata Cozzi, Department of Biology, Roma Tre University, Viale Marconi, Roma, Italy)

Section 8: Health Benefits of Resveratrol against Neuronal diseases

Chapter 18. Resveratrol and Neuroprotection
(Carmem Gottfried, André Quincozes-Santos, Kader Basli and Tristan Richard, Department of Biochemistry, Postgraduate Program of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil, and others)

Chapter 19. Resveratrol and Neurodegenerative Diseases
(Altaf S. Darvesh and Anupam Bishayee, Department of Pharmaceutical Sciences, College of Pharmacy, Northeastern Ohio Medical University, Rootstown, OH, USA, and others)

Section 9: Metabolism and Pharmacokinetics of Resveratrol

Chapter 20. Sources and Food Matrix on the Bioavailability of Resveratrol
(Maria Rotches-Ribalta, Mireia Urpi-Sarda, Sara Tulipani, Pilar Trespalacios, Olha Khymenets, Montse Rabassa-Bonet, Maria Boto-Ordóñez, Rosa Vazquez-Fresno, Mar Garcia-Aloy, Rafael Llorach and Cristina Andres-Lacueva, University of Barcelona, Av Joan XXIII, s/n, Barcelona, Spain, and others)

Chapter 21. Pharmacological Activities, Pharmacokinetics and Delivery Approaches
(Surajit Das and Anumita Chaudhury, Institute of Chemical and Engineering Sciences, Singapore, Republic of Singapore, and others)

Chapter 22. Resveratrol and Cyclodextrins: Recent Advances in Encapsulation
(C. Lucas-Abellán, M. I. Fortea, M. T. Mercader-Ros, A. Martínez-Cachá, J. A. Gabaldón and E. Núñez-Delicado, Universidad Católica San Antonio de Murcia, Murcia, Spain)

Section 10: Health Benefits of Resveratrol: Perspectives

Chapter 23. Clinical Development of Resveratrol
(Ketan R. Patel, William P. Steward, Andreas J. Gescher and Karen Brown, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK)

Chapter 24. Resveratrol Derivatives and Health Benefits
(Simone Fulda, Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany)

Index

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