Respiratory Ventilatory Strategies in Acute and Chronic Respiratory Failure in Idiopathic Pulmonary Diseases: A Practical Approach


Antonio M. Esquinas, MD, PhD, FCCP, FAARC – Intensive Care Unit Hospital Morales Meseguer, Murcia, Spain; Director International School of Non-Invasive Ventilation; Director International Non Invasive Ventilation Expert of College

Series: Pulmonary and Respiratory Diseases and Disorders
BISAC: MED079000

Idiopathic Pulmonary Fibrosis (IPF) represents one of the most important devastating diseases that affects the lungs. Traditionally, the development of acute or chronic respiratory failure in represents an important dilemma for pulmonologists, intensivists, internists and anesthesiologists, due to the limited respiratory and functional reserve of these patients. In the last decade, we have witnessed a novel development of non-invasive mechanical ventilation and high flow oxygenation systems, representing an attractive option for patients compared to those patients with well-known poor results of invasive mechanical ventilation.In this book, we analyze all the options of non-invasive mechanical ventilation, indications, ventilatory modes, protocols, technology, equipment and applications in acute and chronic phase of patients with IPF, in addition to an exhaustive approach of all complementary techniques that optimize the application of these procedures.


(Imprint: Nova Medicine and Health)

Table of Contents


Chapter 1. Introduction: Classification of Interstitial Lung Diseases
(Irene Nieto Codesido, MD, and Pedro J. Marcos, MD, PhD, Respiratory Section, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain, and others)

Chapter 2. Epidemiology of Idiopathic Pulmonary Fibrosis
(Mohamed Y. Elnaggar, MD, and Priyanka Heeru Teckchandani, MD, Department of Pulmonary, Critical Care, and Sleep Medicine, University of California, Irvine, CA, US, and others)

Chapter 3. Basic Key Aspects of Physiology of Idiopathic Pulmonary Fibrosis
(Gregorino Paone, Giulia De Rose and Josuel Ora, Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic, Geriatric Sciences Sapienza University of Rome, Rome, Italy, and others)

Chapter 4. Immunity, Inflammation and Lung Fibrosis
(Thomas Planté-Bordeneuve, MD, and Antoine Froidure, MD, PhD, Pneumology Department, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium, and others)

Chapter 5. Extrapulmonary Alterations in Idiopatic Pulmonary Fibrosis
(Francisco V. Lima and Carlos H. G. Uchôa, PhD, Department of Physical Therapy, University of Brasilia, Brasilia, Brazil, and others)

Chapter 6. Epithelial Damage and Remodeling in Idiopathic Pulmonary Fibrosis
(Antoine Froidure, MD, PhD, Pneumology Department, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium, and others)

Chapter 7. Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis
(Deniz Koksal, MD, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey)

Chapter 8. Biomarkers Idiopathic Pulmonary Fibrosis and Lung Function
(Dorina Esendagli, MD, PhD, Department of Chest Diseases, Baskent University, Ankara, Turkey)

Chapter 9. Gastroesophageal Reflux and Chronic Lung Disease
(Tricia L. Griffiths, MD, Mo’ath Nassar, MD, and Ayman O. Soubani, MD, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, US)

Chapter 10. Idiopathic Pulmonary Fibrosis Complications
(Ken M. Stern, MD, and Huawei Dong, MD, Division of Pulmonary and Critical Care, University of California, Irvine, Orange, CA, US)

Chapter 11. Functional Capacity Assessment in Idiopatic Pulmonary Fibrosis
(Angelo Petroianni, MD, PhD, Arianna Sanna, MD, and Gregorino Paone, MD, Department of Cardiovascular and Respiratory Diseases, Respiratory Diseases Unit, Umberto I Policlinic, Rome, Italy, and others)

Chapter 12. Acute Respiratory Failure in Chronic Interstitial Lung Disease
(Samantha Baah, MD, David J. Nagel, MD, PhD, Aleksandr Kalininskiy, MD, and R. Matthew Kottmann, MD, University of Rochester Medical Center, Department of Pulmonary and Critical Care Medicine, Rochester, NY, US)

Chapter 13. Chronic Respiratory Failure
(Mohammed D. AlAhmari, PhD, and Abdullah A. Ghazwani, Respiratory Care Department, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia)

Chapter 14. The Diagnosis and Treatment of Obstructive Sleep Apnea in Patients with Idiopathic Pulmonary Fibrosis
(Walter Blake Gribben, MD, and Kimberly Truong, MD, Division of Pulmonary Diseases and Critical Care Medicine, University of California, Irvine Medical Center, Orange, CA, US, and others)

Chapter 15. Initial Evaluation of Respiratory Failure Severity for Idiopathic Pulmonary Fibrosis: Disease Severity Staging System for Idiopathic Pulmonary Fibrosis
(Vânia Fernandes, MD, and Carolina Matos Cabo, MD, Pneumology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal)

Chapter 16. Diagnostic Procedures to Perform
(Tomoo Kishaba, Department of Respiratory Medicine, Uruma City, Okinawa, Japan)

Chapter 17. Diagnostic Procedures in Idiopathic Pulmonary Fibrosis: Bronchoscopy and Other Procedures
(Bahman Saatian, MD, and Monique Patel, MD, Department of Medicine, Pulmonary and Critical Care Section, Veterans Affairs Long Beach Healthcare System, Long Beach, CA, US, and others)

Chapter 18. Oxygen Therapy in Patients with Fibrotic Interstitial Lung Disease
(Giuseppe Fiorentino, MD, Anna Annunziata, MD, and Maurizia Lanza, MD, Head of Unit of Respiratory Physiopathology, Monaldi Hospital, Naples, Italy)

Chapter 19. Oxygen Therapy and High-Flow Nasal Cannula
(Ricardo Estêvão Gomes, MD, and Vasco Salgado da Costa, MD, Pulmonology Department, Hospital Garcia de Orta, Almada, Setúbal, Portugal, and others)

Chapter 20. Non-Invasive Ventilation: Continuous Positive Air Pressure Ventilation (CPAP) and Pressure Support Ventilation (PSV)
(Corrado Mollica, MD, Angelo Petroianni, MD, and Edoardo Piervincenzi, MD, Department of Cardiovascular and Respiratory Sciences, Sapienza University, Rome, Italy, and others)

Chapter 21. Idiopathic Pulmonary Fibrosis during Invasive Mechanical Ventilation
(Berrin Er, MD, and Ebru Ortac Ersoy, MD, Associate Professor, Faculty Of Medicine, Medical Intensive Care Unit, Hacettepe University, Ankara, Turkey)

Chapter 22. Idiopatic Pulmonary Fibrosis and Mechanical Ventilation Interaction – Patient Ventilator Asynchrony
(Martin Scharffenberg, MD, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany)

Chapter 23. Weaning from Mechanical Ventilation: How to Approach
(Martin Scharffenberg, MD, and Shashank Shekhar, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and others)

Chapter 24. How Pulmonary Hypertension Influences Weaning from Mechanical Ventilation
(Miguel Guia MD, Andrea Machado, MD, Cátia Pereira, MD, João Carvalho, MD, and Paula Pinto, MD, Serviço de Pneumologia, Hospital Professor Doutor Fernando Fonseca, Lisbon, Portugal, and others)

Chapter 25. Preoperative Evaluation of Patients with Idiopathic Pulmonary Fibrosis
(Habib Md Reazaul Karim, Chinmaya Kumar Panda and Subrata Kumar Singha, AIIMS Hospital Complex, Tatibandh, Raipur, India)

Chapter 26. Idiopathic Pulmonary Fibrosis in Postoperative Conditions
(Güniz Koksal, MD, and Cigdem Akyol Beyoglu, MD, Cerrahpasa Medical Faculty, Department of Anesthesiology and Reanimation, Istanbul Cerrahpasa University, Istanbul, Turkey)

Chapter 27. Extracorporeal Life Support and Unconventional Mode of Respiratory Management
(Federica Lo Presti, MD, and Luca S. De Santo, MD, Department of Translational Medical Sciences, Universitàdegli Studidella Campania “L. Vanvitelli”, Naples, Italy)

Chapter 28. Do-Not-Intubate (DNI) Order in Acute Respiratory Management
(A. Úbeda, MD, PhD, and I. Fernández, MD, Intensive Care Unit, Hospital Punta de Europa, Algeciras, Spain)

Chapter 29. Management of Idiopathic Pulmonary Fibrosis in Pneumology Department
(Antoine Froidure, MD, PhD, Pneumology Department, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium, and others)

Chapter 30. Idiopathic Pulmonary Fibrosis: Clinical Behavior and Aging
(Sara Campos Silva, MD, Pulmonology Department, Hospital Santa Marta, Centro Hospitalar, Universitário Lisboa Central, Lisbon, Portugal)

Chapter 31. Pharmacological Management of Progressive-Fibrosing Interstitial Lung Diseases
(Kevin Lazo, DO and Marwah Ibrahem, DO, Fellow in Pulmonary and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, US, and others)

Chapter 32. Long Term Management of Idiopathic Pulmonary Fibrosis Using Non-Invasive and CPAP Oxygen Therapy
(Zuhal Karakurt and Meltem Ağca, Pulmonology and Critical Care Specialist, University of Health Sciences, Istanbul, Turkey, and others)

Chapter 33. Chronic Monitoring and Respiratory Management in Idiopathic Pulmonary Fibrosis
(Marcos Las Heras, Subjefe Operativo Terapia Intensiva de Adultos, Medico Asociado Sección Neumonologia, Buenos Aires, Argentina)

Chapter 34. Homecare Platform for Remote Monitoring of Patients with Idiopathic Pulmonary Fibrosis
(Carolina Cabo, MD, Vânia Fernandes, MD, and Margarida Afonso, MD, Pneumology Unit, Coimbra University Hospital, Coimbra, Portugal)

Chapter 35. Mortality in Acute and Chronic Management of Idiopathic Pulmonary Fibrosis
(Zuhal Karakurt and Özlem Soğukpınar, Pulmonology and Critical Care Specialist, University of Health Sciences, Istanbul, Turkey, and others)

Chapter 36. Rehabilitation in Patients after Lung Transplantation
(Annalisa Fui, Guido Vagheggini, Antonella Fossi, Behar Cekorja and Elena Bargagli, Pulmonary Medicine Unit, University of Siena, Viale Bracci, Siena, Italy, and others)

Chapter 37. Pulmonary Rehabilitation in Fibrosing Interstitial Lung Diseases and Idiopatic Pulmonary Fibrosis: Key Practical Aspects
(Guido Vagheggini, Elena Bargagli, Behar Cekorja and Eugenia Panait, Cardiac and Pulmonary Rehabilitation Unit, Auxilium Vitae Rehabilitation Centre, Volterra, Pisa, Italy, and others)

Chapter 38. Pulmonary Rehabilitation in Idiopathic Pulmonary Fibrosis. Evidence-Based Guidelines
(Vânia Caldeira, MD, Pneumology Department, Hospital Santa Marta, Lisboa, Portugal)

Chapter 39. Psychiatric and Psychological Disorders in Idiopathic Pulmonary Fibrosis
(Rafael Soler, MD, Department of Neurology, University Hospital, Melilla, Spain)

Chapter 40. Idiopathic Pulmonary Fibrosis (IPF) and Evidence-Based Guidelines
(Mehmet Selim Comez, MD, Anesthesiology and Reanimation Department, Tayfur Ata Sökmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey)


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